Novel Methylation Biomarkers for Colorectal Cancer Prognosis

Colorectal cancer (CRC) comprises the third most common cancer worldwide and the second regarding number of deaths. In order to make a correct and early diagnosis to predict metastasis formation, biomarkers are an important tool. Although there are multiple signaling pathways associated with cancer...

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Autores principales:	Alvaro Gutierrez, Hannah Demond, Priscilla Brebi, Carmen Gloria Ili
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	colorectal cancer methylation prognosis biomarkers Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/ae4d14f15bcc46308b9d6a4cff2a70f9
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spelling	oai:doaj.org-article:ae4d14f15bcc46308b9d6a4cff2a70f92021-11-25T16:54:24ZNovel Methylation Biomarkers for Colorectal Cancer Prognosis10.3390/biom111117222218-273Xhttps://doaj.org/article/ae4d14f15bcc46308b9d6a4cff2a70f92021-11-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1722https://doaj.org/toc/2218-273XColorectal cancer (CRC) comprises the third most common cancer worldwide and the second regarding number of deaths. In order to make a correct and early diagnosis to predict metastasis formation, biomarkers are an important tool. Although there are multiple signaling pathways associated with cancer progression, the most recognized are the MAPK pathway, p53 pathway, and TGF-β pathway. These pathways regulate many important functions in the cell, such as cell cycle regulation, proliferation, differentiation, and metastasis formation, among others. Changes in expression in genes belonging to these pathways are drivers of carcinogenesis. Often these expression changes are caused by mutations; however, epigenetic changes, such as DNA methylation, are increasingly acknowledged to play a role in the deregulation of oncogenic genes. This makes DNA methylation changes an interesting biomarkers in cancer. Among the newly identified biomarkers for CRC metastasis <i>INHBB</i>, <i>SMOC2</i>, <i>BDNF</i>, and <i>TBRG4</i> are included, all of which are highly deregulated by methylation and closely associated with metastasis. The identification of such biomarkers in metastasis of CRC may allow a better treatment and early identification of cancer formation in order to perform better diagnostics and improve the life expectancy.Alvaro GutierrezHannah DemondPriscilla BrebiCarmen Gloria IliMDPI AGarticlecolorectal cancermethylationprognosisbiomarkersMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1722, p 1722 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal cancer methylation prognosis biomarkers Microbiology QR1-502
spellingShingle	colorectal cancer methylation prognosis biomarkers Microbiology QR1-502 Alvaro Gutierrez Hannah Demond Priscilla Brebi Carmen Gloria Ili Novel Methylation Biomarkers for Colorectal Cancer Prognosis
description	Colorectal cancer (CRC) comprises the third most common cancer worldwide and the second regarding number of deaths. In order to make a correct and early diagnosis to predict metastasis formation, biomarkers are an important tool. Although there are multiple signaling pathways associated with cancer progression, the most recognized are the MAPK pathway, p53 pathway, and TGF-β pathway. These pathways regulate many important functions in the cell, such as cell cycle regulation, proliferation, differentiation, and metastasis formation, among others. Changes in expression in genes belonging to these pathways are drivers of carcinogenesis. Often these expression changes are caused by mutations; however, epigenetic changes, such as DNA methylation, are increasingly acknowledged to play a role in the deregulation of oncogenic genes. This makes DNA methylation changes an interesting biomarkers in cancer. Among the newly identified biomarkers for CRC metastasis <i>INHBB</i>, <i>SMOC2</i>, <i>BDNF</i>, and <i>TBRG4</i> are included, all of which are highly deregulated by methylation and closely associated with metastasis. The identification of such biomarkers in metastasis of CRC may allow a better treatment and early identification of cancer formation in order to perform better diagnostics and improve the life expectancy.
format	article
author	Alvaro Gutierrez Hannah Demond Priscilla Brebi Carmen Gloria Ili
author_facet	Alvaro Gutierrez Hannah Demond Priscilla Brebi Carmen Gloria Ili
author_sort	Alvaro Gutierrez
title	Novel Methylation Biomarkers for Colorectal Cancer Prognosis
title_short	Novel Methylation Biomarkers for Colorectal Cancer Prognosis
title_full	Novel Methylation Biomarkers for Colorectal Cancer Prognosis
title_fullStr	Novel Methylation Biomarkers for Colorectal Cancer Prognosis
title_full_unstemmed	Novel Methylation Biomarkers for Colorectal Cancer Prognosis
title_sort	novel methylation biomarkers for colorectal cancer prognosis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ae4d14f15bcc46308b9d6a4cff2a70f9
work_keys_str_mv	AT alvarogutierrez novelmethylationbiomarkersforcolorectalcancerprognosis AT hannahdemond novelmethylationbiomarkersforcolorectalcancerprognosis AT priscillabrebi novelmethylationbiomarkersforcolorectalcancerprognosis AT carmengloriaili novelmethylationbiomarkersforcolorectalcancerprognosis
_version_	1718412856735563776

Novel Methylation Biomarkers for Colorectal Cancer Prognosis

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