Comparison of the fertility of tumor suppressor gene-deficient C57BL/6 mouse strains reveals stable reproductive aging and novel pleiotropic gene
Abstract Tumor suppressor genes are involved in maintaining genome integrity during reproduction (e.g., meiosis). Thus, deleterious alleles in tumor suppressor-deficient mice would exhibit higher mortality during the perinatal period. A recent aging model proposes that perinatal mortality and age-re...
Guardado en:
Autores principales: | Masaoki Kohzaki, Akira Ootsuyama, Toshiyuki Umata, Ryuji Okazaki |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/ae51f3e286524bcbacde0b1bd96086a3 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Hierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice
por: Yasuyuki Horii, et al.
Publicado: (2017) -
Attentional processing in C57BL/6J mice exposed to developmental vitamin D deficiency.
por: Lauren R Harms, et al.
Publicado: (2012) -
LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer
por: Qiuhui Li, et al.
Publicado: (2019) -
Sensitivity to tumor development by TALEN-mediated Trp53 mutant genes in the susceptible FVB/N mice and the resistance C57BL/6 mice
por: Woo Bin Yun, et al.
Publicado: (2021) -
Batesian mimicry has evolved with deleterious effects of the pleiotropic gene doublesex
por: Shinya Komata, et al.
Publicado: (2020)