A very rare case of HPV-53-related cervical cancer, in a 79-year-old woman with a previous history of negative Pap cytology

Roberta Zappacosta,1 Giuseppe Lattanzio,2 Patrizia Viola,2 Manuel Maria Ianieri,3 Daniela Maria Pia Gatta,1 Sandra Rosini11Cytopathology Unit, Experimental and Clinical Sciences Department, Gabriele d’Annunzio University of Chieti-Pescara, Chieti, Italy; 2Surgical Pathology Unit, 3Obstetri...

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Autores principales:	Zappacosta R, Lattanzio G, Viola P, Ianieri MM, Gatta DMP, Rosini S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	cervical cancer old women HPV-53 molecular tests Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/ae52af112656433aafdfce4999d6b29f
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spelling	oai:doaj.org-article:ae52af112656433aafdfce4999d6b29f2021-12-02T00:33:32ZA very rare case of HPV-53-related cervical cancer, in a 79-year-old woman with a previous history of negative Pap cytology1178-1998https://doaj.org/article/ae52af112656433aafdfce4999d6b29f2014-04-01T00:00:00Zhttps://www.dovepress.com/a-very-rare-case-of-hpv-53-related-cervical-cancer-in-a-79-year-old-wo-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Roberta Zappacosta,1 Giuseppe Lattanzio,2 Patrizia Viola,2 Manuel Maria Ianieri,3 Daniela Maria Pia Gatta,1 Sandra Rosini11Cytopathology Unit, Experimental and Clinical Sciences Department, Gabriele d’Annunzio University of Chieti-Pescara, Chieti, Italy; 2Surgical Pathology Unit, 3Obstetrics and Gynecology Unit, SS Annunziata Hospital, Chieti, ItalyAbstract: The introduction of organized cervical cancer (CC) screening programs has drastically reduced the prevalence of CC. However the incidence is still too high, especially among elderly women. All guidelines strongly recommend a regular Papanicolaou (Pap) testing for young and middle-aged patients. On the other hand, many international professional societies no longer advise screening in women who have undergone hysterectomy, and in women aged 65 years and above, who have a previous history of regular Pap smears. Here we report the case of poorly differentiated CC, involving the pelvic lymph nodes and urinary bladder, occurring in a 79-year-old woman who regularly underwent Pap tests, with no reported cytological abnormalities. In this very rare case, the CC cells, as well as cells from metastatic lymph nodes and cells from urinary specimens, molecularly showed human papilloma virus (HPV)-53. With the limitations of a single case, this report brings important information to prevent CC in elderly patients: the utility of molecular tests to increase sensitivity of Pap smears in postmenopausal women; the importance of HPV-53 as one of the four “emergent” genotypes having a possible role in oncogenesis; and the presence of HPV-53 in lymph node metastases from cervical carcinoma, which would support the role of this virus in the maintenance of malignant status.Keywords: old women, molecular tests, cervical cancer screening, HPV-DNA test, HPV genotypingA Letter to the editor has been received and published for this articleCorrigendum for this paper has been publishedZappacosta RLattanzio GViola PIanieri MMGatta DMPRosini SDove Medical Pressarticlecervical cancerold womenHPV-53molecular testsGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 9, Pp 683-688 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	cervical cancer old women HPV-53 molecular tests Geriatrics RC952-954.6
spellingShingle	cervical cancer old women HPV-53 molecular tests Geriatrics RC952-954.6 Zappacosta R Lattanzio G Viola P Ianieri MM Gatta DMP Rosini S A very rare case of HPV-53-related cervical cancer, in a 79-year-old woman with a previous history of negative Pap cytology
description	Roberta Zappacosta,1 Giuseppe Lattanzio,2 Patrizia Viola,2 Manuel Maria Ianieri,3 Daniela Maria Pia Gatta,1 Sandra Rosini11Cytopathology Unit, Experimental and Clinical Sciences Department, Gabriele d’Annunzio University of Chieti-Pescara, Chieti, Italy; 2Surgical Pathology Unit, 3Obstetrics and Gynecology Unit, SS Annunziata Hospital, Chieti, ItalyAbstract: The introduction of organized cervical cancer (CC) screening programs has drastically reduced the prevalence of CC. However the incidence is still too high, especially among elderly women. All guidelines strongly recommend a regular Papanicolaou (Pap) testing for young and middle-aged patients. On the other hand, many international professional societies no longer advise screening in women who have undergone hysterectomy, and in women aged 65 years and above, who have a previous history of regular Pap smears. Here we report the case of poorly differentiated CC, involving the pelvic lymph nodes and urinary bladder, occurring in a 79-year-old woman who regularly underwent Pap tests, with no reported cytological abnormalities. In this very rare case, the CC cells, as well as cells from metastatic lymph nodes and cells from urinary specimens, molecularly showed human papilloma virus (HPV)-53. With the limitations of a single case, this report brings important information to prevent CC in elderly patients: the utility of molecular tests to increase sensitivity of Pap smears in postmenopausal women; the importance of HPV-53 as one of the four “emergent” genotypes having a possible role in oncogenesis; and the presence of HPV-53 in lymph node metastases from cervical carcinoma, which would support the role of this virus in the maintenance of malignant status.Keywords: old women, molecular tests, cervical cancer screening, HPV-DNA test, HPV genotypingA Letter to the editor has been received and published for this articleCorrigendum for this paper has been published
format	article
author	Zappacosta R Lattanzio G Viola P Ianieri MM Gatta DMP Rosini S
author_facet	Zappacosta R Lattanzio G Viola P Ianieri MM Gatta DMP Rosini S
author_sort	Zappacosta R
title	A very rare case of HPV-53-related cervical cancer, in a 79-year-old woman with a previous history of negative Pap cytology
title_short	A very rare case of HPV-53-related cervical cancer, in a 79-year-old woman with a previous history of negative Pap cytology
title_full	A very rare case of HPV-53-related cervical cancer, in a 79-year-old woman with a previous history of negative Pap cytology
title_fullStr	A very rare case of HPV-53-related cervical cancer, in a 79-year-old woman with a previous history of negative Pap cytology
title_full_unstemmed	A very rare case of HPV-53-related cervical cancer, in a 79-year-old woman with a previous history of negative Pap cytology
title_sort	very rare case of hpv-53-related cervical cancer, in a 79-year-old woman with a previous history of negative pap cytology
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/ae52af112656433aafdfce4999d6b29f
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A very rare case of HPV-53-related cervical cancer, in a 79-year-old woman with a previous history of negative Pap cytology

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