Viral N 6-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus

Here, Xue et al. identify N 6-methyladenosine (m6A) modification sites in RNAs of respiratory syncytial virus (RSV) and show that these sites, particularly sites in the transcript encoding for the viral glycoprotein, affect virus replication in primary human cells and cotton rats.

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Autores principales:	Miaoge Xue, Boxuan Simen Zhao, Zijie Zhang, Mijia Lu, Olivia Harder, Phylip Chen, Zhike Lu, Anzhong Li, Yuanmei Ma, Yunsheng Xu, Xueya Liang, Jiyong Zhou, Stefan Niewiesk, Mark E. Peeples, Chuan He, Jianrong Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ae5353928f864471a17a92fe4c1248b7
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spelling	oai:doaj.org-article:ae5353928f864471a17a92fe4c1248b72021-12-02T17:31:21ZViral N 6-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus10.1038/s41467-019-12504-y2041-1723https://doaj.org/article/ae5353928f864471a17a92fe4c1248b72019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12504-yhttps://doaj.org/toc/2041-1723Here, Xue et al. identify N 6-methyladenosine (m6A) modification sites in RNAs of respiratory syncytial virus (RSV) and show that these sites, particularly sites in the transcript encoding for the viral glycoprotein, affect virus replication in primary human cells and cotton rats.Miaoge XueBoxuan Simen ZhaoZijie ZhangMijia LuOlivia HarderPhylip ChenZhike LuAnzhong LiYuanmei MaYunsheng XuXueya LiangJiyong ZhouStefan NiewieskMark E. PeeplesChuan HeJianrong LiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Miaoge Xue Boxuan Simen Zhao Zijie Zhang Mijia Lu Olivia Harder Phylip Chen Zhike Lu Anzhong Li Yuanmei Ma Yunsheng Xu Xueya Liang Jiyong Zhou Stefan Niewiesk Mark E. Peeples Chuan He Jianrong Li Viral N 6-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus
description	Here, Xue et al. identify N 6-methyladenosine (m6A) modification sites in RNAs of respiratory syncytial virus (RSV) and show that these sites, particularly sites in the transcript encoding for the viral glycoprotein, affect virus replication in primary human cells and cotton rats.
format	article
author	Miaoge Xue Boxuan Simen Zhao Zijie Zhang Mijia Lu Olivia Harder Phylip Chen Zhike Lu Anzhong Li Yuanmei Ma Yunsheng Xu Xueya Liang Jiyong Zhou Stefan Niewiesk Mark E. Peeples Chuan He Jianrong Li
author_facet	Miaoge Xue Boxuan Simen Zhao Zijie Zhang Mijia Lu Olivia Harder Phylip Chen Zhike Lu Anzhong Li Yuanmei Ma Yunsheng Xu Xueya Liang Jiyong Zhou Stefan Niewiesk Mark E. Peeples Chuan He Jianrong Li
author_sort	Miaoge Xue
title	Viral N 6-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus
title_short	Viral N 6-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus
title_full	Viral N 6-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus
title_fullStr	Viral N 6-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus
title_full_unstemmed	Viral N 6-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus
title_sort	viral n 6-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ae5353928f864471a17a92fe4c1248b7
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Viral N 6-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus

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