Viral N 6-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus
Here, Xue et al. identify N 6-methyladenosine (m6A) modification sites in RNAs of respiratory syncytial virus (RSV) and show that these sites, particularly sites in the transcript encoding for the viral glycoprotein, affect virus replication in primary human cells and cotton rats.
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Autores principales: | Miaoge Xue, Boxuan Simen Zhao, Zijie Zhang, Mijia Lu, Olivia Harder, Phylip Chen, Zhike Lu, Anzhong Li, Yuanmei Ma, Yunsheng Xu, Xueya Liang, Jiyong Zhou, Stefan Niewiesk, Mark E. Peeples, Chuan He, Jianrong Li |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
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Materias: | |
Acceso en línea: | https://doaj.org/article/ae5353928f864471a17a92fe4c1248b7 |
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