Effect of weight loss on adipokine levels in obese patients

Catherine Rolland, Michelle Hession, Iain BroomCentre for Obesity Research and Epidemiology, Robert Gordon University, Aberdeen, Scotland, UKBackground: Adipose tissue functions as an endocrine organ by releasing adipokines which have important roles in the regulation of inflammation and insulin sen...

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Autores principales:	Hession M, C, Roll, Broom I
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/ae5433dd19e24ff1bb6f239259b9a8d2
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spelling	oai:doaj.org-article:ae5433dd19e24ff1bb6f239259b9a8d22021-12-02T01:22:15ZEffect of weight loss on adipokine levels in obese patients1178-7007https://doaj.org/article/ae5433dd19e24ff1bb6f239259b9a8d22011-08-01T00:00:00Zhttp://www.dovepress.com/effect-of-weight-loss-on-adipokine-levels-in-obese-patients-a8015https://doaj.org/toc/1178-7007Catherine Rolland, Michelle Hession, Iain BroomCentre for Obesity Research and Epidemiology, Robert Gordon University, Aberdeen, Scotland, UKBackground: Adipose tissue functions as an endocrine organ by releasing adipokines which have important roles in the regulation of inflammation and insulin sensitivity. Although there is evidence of improvement in circulating levels of adipokines with weight loss, few studies relate such changes to specific diets. We investigated the effects of weight loss achieved by two different diets on circulating adipokine levels in obese individuals.Methods: A total of 120 obese patients (body mass index &ge; 35 kg/m2) underwent a three-month screening period on a low-fat, reduced-calorie diet. Patients failing to achieve a 5% weight loss using this approach were randomly allocated to either a low carbohydrate/high protein diet (n = 17) or to a commercial very low calorie diet (LighterLife&reg;, n = 14) for a period of nine months.Results: At nine months, a significant weight loss was only maintained for LighterLife&reg; (&minus;32.3 &plusmn; 22.7 kg, P &lt; 0.0001) but not on the low carbohydrate/high protein diet. Changes in adiponectin (15.8 &plusmn; 17.1 ng/mL versus &minus;0.8 &plusmn; 6.2 ng/mL, P = 0.003) and leptin (&minus;17.6 &plusmn; 24.3 ng/mL versus &minus;3.0 &plusmn; 9.2 ng/mL, P = 0.049) at nine months were significantly greater for LighterLife&reg; than for the low carbohydrate/high protein diet, which may reflect greater weight loss and decrease in fat mass. Changes in tumor necrosis factor-alpha, interleukin-6, and plasminogen activator inhibitor type 1 did not differ significantly between the dietary interventions at nine months.Conclusion: A significant weight loss of 23.8% from baseline weight was observed using a very low calorie diet and resulted in significant improvements in circulating levels of leptin, plasminogen activator inhibitor type 1, and adiponectin, which are likely to be due to weight loss and not macronutrient intake.Keywords: weight loss, adipokine, obesityHession MCRollBroom IDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2011, Iss default, Pp 315-323 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Hession M C Roll Broom I Effect of weight loss on adipokine levels in obese patients
description	Catherine Rolland, Michelle Hession, Iain BroomCentre for Obesity Research and Epidemiology, Robert Gordon University, Aberdeen, Scotland, UKBackground: Adipose tissue functions as an endocrine organ by releasing adipokines which have important roles in the regulation of inflammation and insulin sensitivity. Although there is evidence of improvement in circulating levels of adipokines with weight loss, few studies relate such changes to specific diets. We investigated the effects of weight loss achieved by two different diets on circulating adipokine levels in obese individuals.Methods: A total of 120 obese patients (body mass index &ge; 35 kg/m2) underwent a three-month screening period on a low-fat, reduced-calorie diet. Patients failing to achieve a 5% weight loss using this approach were randomly allocated to either a low carbohydrate/high protein diet (n = 17) or to a commercial very low calorie diet (LighterLife&reg;, n = 14) for a period of nine months.Results: At nine months, a significant weight loss was only maintained for LighterLife&reg; (&minus;32.3 &plusmn; 22.7 kg, P &lt; 0.0001) but not on the low carbohydrate/high protein diet. Changes in adiponectin (15.8 &plusmn; 17.1 ng/mL versus &minus;0.8 &plusmn; 6.2 ng/mL, P = 0.003) and leptin (&minus;17.6 &plusmn; 24.3 ng/mL versus &minus;3.0 &plusmn; 9.2 ng/mL, P = 0.049) at nine months were significantly greater for LighterLife&reg; than for the low carbohydrate/high protein diet, which may reflect greater weight loss and decrease in fat mass. Changes in tumor necrosis factor-alpha, interleukin-6, and plasminogen activator inhibitor type 1 did not differ significantly between the dietary interventions at nine months.Conclusion: A significant weight loss of 23.8% from baseline weight was observed using a very low calorie diet and resulted in significant improvements in circulating levels of leptin, plasminogen activator inhibitor type 1, and adiponectin, which are likely to be due to weight loss and not macronutrient intake.Keywords: weight loss, adipokine, obesity
format	article
author	Hession M C Roll Broom I
author_facet	Hession M C Roll Broom I
author_sort	Hession M
title	Effect of weight loss on adipokine levels in obese patients
title_short	Effect of weight loss on adipokine levels in obese patients
title_full	Effect of weight loss on adipokine levels in obese patients
title_fullStr	Effect of weight loss on adipokine levels in obese patients
title_full_unstemmed	Effect of weight loss on adipokine levels in obese patients
title_sort	effect of weight loss on adipokine levels in obese patients
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/ae5433dd19e24ff1bb6f239259b9a8d2
work_keys_str_mv	AT hessionm effectofweightlossonadipokinelevelsinobesepatients AT c effectofweightlossonadipokinelevelsinobesepatients AT roll effectofweightlossonadipokinelevelsinobesepatients AT broomi effectofweightlossonadipokinelevelsinobesepatients
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Effect of weight loss on adipokine levels in obese patients

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