Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice

Idiopathic pulmonary fibrosis (IPF) is a devastating disease with poor prognosis. Here, the authors show that deficiency of the E3 ubiqutin-protein ligase Nedd4-2 in airway epithelial cells causes IPF-like disease in adult mice. This model may aid studies of the pathogenesis and therapy of IPF.

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Autores principales:	Julia Duerr, Dominik H. W. Leitz, Magdalena Szczygiel, Dmytro Dvornikov, Simon G. Fraumann, Clemens Kreutz, Piotr K. Zadora, Ayça Seyhan Agircan, Philip Konietzke, Theresa A. Engelmann, Jan Hegermann, Surafel Mulugeta, Hiroshi Kawabe, Lars Knudsen, Matthias Ochs, Daniela Rotin, Thomas Muley, Michael Kreuter, Felix J. F. Herth, Mark O. Wielpütz, Michael F. Beers, Ursula Klingmüller, Marcus A. Mall
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ae55c88d44b14c0496555b2c7a52b8da
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spelling	oai:doaj.org-article:ae55c88d44b14c0496555b2c7a52b8da2021-12-02T15:37:20ZConditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice10.1038/s41467-020-15743-62041-1723https://doaj.org/article/ae55c88d44b14c0496555b2c7a52b8da2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15743-6https://doaj.org/toc/2041-1723Idiopathic pulmonary fibrosis (IPF) is a devastating disease with poor prognosis. Here, the authors show that deficiency of the E3 ubiqutin-protein ligase Nedd4-2 in airway epithelial cells causes IPF-like disease in adult mice. This model may aid studies of the pathogenesis and therapy of IPF.Julia DuerrDominik H. W. LeitzMagdalena SzczygielDmytro DvornikovSimon G. FraumannClemens KreutzPiotr K. ZadoraAyça Seyhan AgircanPhilip KonietzkeTheresa A. EngelmannJan HegermannSurafel MulugetaHiroshi KawabeLars KnudsenMatthias OchsDaniela RotinThomas MuleyMichael KreuterFelix J. F. HerthMark O. WielpützMichael F. BeersUrsula KlingmüllerMarcus A. MallNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Julia Duerr Dominik H. W. Leitz Magdalena Szczygiel Dmytro Dvornikov Simon G. Fraumann Clemens Kreutz Piotr K. Zadora Ayça Seyhan Agircan Philip Konietzke Theresa A. Engelmann Jan Hegermann Surafel Mulugeta Hiroshi Kawabe Lars Knudsen Matthias Ochs Daniela Rotin Thomas Muley Michael Kreuter Felix J. F. Herth Mark O. Wielpütz Michael F. Beers Ursula Klingmüller Marcus A. Mall Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice
description	Idiopathic pulmonary fibrosis (IPF) is a devastating disease with poor prognosis. Here, the authors show that deficiency of the E3 ubiqutin-protein ligase Nedd4-2 in airway epithelial cells causes IPF-like disease in adult mice. This model may aid studies of the pathogenesis and therapy of IPF.
format	article
author	Julia Duerr Dominik H. W. Leitz Magdalena Szczygiel Dmytro Dvornikov Simon G. Fraumann Clemens Kreutz Piotr K. Zadora Ayça Seyhan Agircan Philip Konietzke Theresa A. Engelmann Jan Hegermann Surafel Mulugeta Hiroshi Kawabe Lars Knudsen Matthias Ochs Daniela Rotin Thomas Muley Michael Kreuter Felix J. F. Herth Mark O. Wielpütz Michael F. Beers Ursula Klingmüller Marcus A. Mall
author_facet	Julia Duerr Dominik H. W. Leitz Magdalena Szczygiel Dmytro Dvornikov Simon G. Fraumann Clemens Kreutz Piotr K. Zadora Ayça Seyhan Agircan Philip Konietzke Theresa A. Engelmann Jan Hegermann Surafel Mulugeta Hiroshi Kawabe Lars Knudsen Matthias Ochs Daniela Rotin Thomas Muley Michael Kreuter Felix J. F. Herth Mark O. Wielpütz Michael F. Beers Ursula Klingmüller Marcus A. Mall
author_sort	Julia Duerr
title	Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice
title_short	Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice
title_full	Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice
title_fullStr	Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice
title_full_unstemmed	Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice
title_sort	conditional deletion of nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ae55c88d44b14c0496555b2c7a52b8da
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Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice

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