Warthy-Basaloid Squamous Cell Carcinoma of Penile – Case Report

ObjectiveThe aim of the study was to present a case of penile squamous cell carcinoma and immunohistochemical identification and evaluation of E-cadherin and β-catenin expression.MethodsWe are presenting a 70-year old man with a variant of penile squamous cell carcinoma with mixed warty and basaloid...

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Autores principales:	Natalia Domian, Grzegorz Młynarczyk, Irena Kasacka
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	penile squamous cell carcinoma warty carcinoma basaloid carcinoma human papillomavirus adhesion molecules Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/ae588038c9e44f9a8480abb8f653a951
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spelling	oai:doaj.org-article:ae588038c9e44f9a8480abb8f653a9512021-11-11T10:22:34ZWarthy-Basaloid Squamous Cell Carcinoma of Penile – Case Report2234-943X10.3389/fonc.2021.765640https://doaj.org/article/ae588038c9e44f9a8480abb8f653a9512021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.765640/fullhttps://doaj.org/toc/2234-943XObjectiveThe aim of the study was to present a case of penile squamous cell carcinoma and immunohistochemical identification and evaluation of E-cadherin and β-catenin expression.MethodsWe are presenting a 70-year old man with a variant of penile squamous cell carcinoma with mixed warty and basaloid features. After diagnosis, the patient underwent partial penectomy. Samples taken from the material after surgery were subjected to basic histological staining and immunohistochemical identification of E-cadherin and β-catenin. A Real-time PCR study was conducted to investigate the expression of E-cadherin and β-catenin.ResultsRoutine histopathological examinations revealed the characteristic features of warty-basaloid squamous cell carcinoma. In the case studied, a positive immunohistochemical reaction was observed for E-cadherin and β-catenin. QRT-PCR analysis showed a statistically significant decrease in E-cadherin expression in tumor samples compared to healthy tissue. In contrast, expression of the gene encoding β-catenin was slightly higher in tumor samples compared to normal tissue.ConclusionsThe reduced level of the complex of adhesive elements, E-cadherin-β-catenin, disturbs cell differentiation, promotes a more invasive phenotype-stromal infiltration and the formation of distant metastases. In the described case of the penile tumor, a decrease in E-cadherin expression was noted, which could be related to the occurrence of neoplastic infiltration of the spongy body space. In summary, E-cadherin and β-catenin expression and the immunoreactivity of these proteins are expressed at different levels in tumor cells and in penile interstitial cells. Regulation of expression during various physiological and pathophysiological processes indicates a potentially important role of E-cadherin and β-catenin in cell proliferation and adhesion.Natalia DomianGrzegorz MłynarczykIrena KasackaFrontiers Media S.A.articlepenile squamous cell carcinomawarty carcinomabasaloid carcinomahuman papillomavirusadhesion moleculesNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	penile squamous cell carcinoma warty carcinoma basaloid carcinoma human papillomavirus adhesion molecules Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	penile squamous cell carcinoma warty carcinoma basaloid carcinoma human papillomavirus adhesion molecules Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Natalia Domian Grzegorz Młynarczyk Irena Kasacka Warthy-Basaloid Squamous Cell Carcinoma of Penile – Case Report
description	ObjectiveThe aim of the study was to present a case of penile squamous cell carcinoma and immunohistochemical identification and evaluation of E-cadherin and β-catenin expression.MethodsWe are presenting a 70-year old man with a variant of penile squamous cell carcinoma with mixed warty and basaloid features. After diagnosis, the patient underwent partial penectomy. Samples taken from the material after surgery were subjected to basic histological staining and immunohistochemical identification of E-cadherin and β-catenin. A Real-time PCR study was conducted to investigate the expression of E-cadherin and β-catenin.ResultsRoutine histopathological examinations revealed the characteristic features of warty-basaloid squamous cell carcinoma. In the case studied, a positive immunohistochemical reaction was observed for E-cadherin and β-catenin. QRT-PCR analysis showed a statistically significant decrease in E-cadherin expression in tumor samples compared to healthy tissue. In contrast, expression of the gene encoding β-catenin was slightly higher in tumor samples compared to normal tissue.ConclusionsThe reduced level of the complex of adhesive elements, E-cadherin-β-catenin, disturbs cell differentiation, promotes a more invasive phenotype-stromal infiltration and the formation of distant metastases. In the described case of the penile tumor, a decrease in E-cadherin expression was noted, which could be related to the occurrence of neoplastic infiltration of the spongy body space. In summary, E-cadherin and β-catenin expression and the immunoreactivity of these proteins are expressed at different levels in tumor cells and in penile interstitial cells. Regulation of expression during various physiological and pathophysiological processes indicates a potentially important role of E-cadherin and β-catenin in cell proliferation and adhesion.
format	article
author	Natalia Domian Grzegorz Młynarczyk Irena Kasacka
author_facet	Natalia Domian Grzegorz Młynarczyk Irena Kasacka
author_sort	Natalia Domian
title	Warthy-Basaloid Squamous Cell Carcinoma of Penile – Case Report
title_short	Warthy-Basaloid Squamous Cell Carcinoma of Penile – Case Report
title_full	Warthy-Basaloid Squamous Cell Carcinoma of Penile – Case Report
title_fullStr	Warthy-Basaloid Squamous Cell Carcinoma of Penile – Case Report
title_full_unstemmed	Warthy-Basaloid Squamous Cell Carcinoma of Penile – Case Report
title_sort	warthy-basaloid squamous cell carcinoma of penile – case report
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ae588038c9e44f9a8480abb8f653a951
work_keys_str_mv	AT nataliadomian warthybasaloidsquamouscellcarcinomaofpenilecasereport AT grzegorzmłynarczyk warthybasaloidsquamouscellcarcinomaofpenilecasereport AT irenakasacka warthybasaloidsquamouscellcarcinomaofpenilecasereport
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Warthy-Basaloid Squamous Cell Carcinoma of Penile – Case Report

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