Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway

Astrocytic phagocytosis has been shown to play a role in synaptic pruning during development, but whether adult astrocytes possess phagocytic ability is unclear. Here the authors show that following brain ischemia, reactive astrocytes become phagocytic and engulf debris via the ABCA1 pathway.

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Autores principales:	Yosuke M. Morizawa, Yuri Hirayama, Nobuhiko Ohno, Shinsuke Shibata, Eiji Shigetomi, Yang Sui, Junichi Nabekura, Koichi Sato, Fumikazu Okajima, Hirohide Takebayashi, Hideyuki Okano, Schuichi Koizumi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ae5888d09dbf4fd4aac1a32a1f9621b4
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spelling	oai:doaj.org-article:ae5888d09dbf4fd4aac1a32a1f9621b42021-12-02T13:57:33ZReactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway10.1038/s41467-017-00037-12041-1723https://doaj.org/article/ae5888d09dbf4fd4aac1a32a1f9621b42017-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00037-1https://doaj.org/toc/2041-1723Astrocytic phagocytosis has been shown to play a role in synaptic pruning during development, but whether adult astrocytes possess phagocytic ability is unclear. Here the authors show that following brain ischemia, reactive astrocytes become phagocytic and engulf debris via the ABCA1 pathway.Yosuke M. MorizawaYuri HirayamaNobuhiko OhnoShinsuke ShibataEiji ShigetomiYang SuiJunichi NabekuraKoichi SatoFumikazu OkajimaHirohide TakebayashiHideyuki OkanoSchuichi KoizumiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yosuke M. Morizawa Yuri Hirayama Nobuhiko Ohno Shinsuke Shibata Eiji Shigetomi Yang Sui Junichi Nabekura Koichi Sato Fumikazu Okajima Hirohide Takebayashi Hideyuki Okano Schuichi Koizumi Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway
description	Astrocytic phagocytosis has been shown to play a role in synaptic pruning during development, but whether adult astrocytes possess phagocytic ability is unclear. Here the authors show that following brain ischemia, reactive astrocytes become phagocytic and engulf debris via the ABCA1 pathway.
format	article
author	Yosuke M. Morizawa Yuri Hirayama Nobuhiko Ohno Shinsuke Shibata Eiji Shigetomi Yang Sui Junichi Nabekura Koichi Sato Fumikazu Okajima Hirohide Takebayashi Hideyuki Okano Schuichi Koizumi
author_facet	Yosuke M. Morizawa Yuri Hirayama Nobuhiko Ohno Shinsuke Shibata Eiji Shigetomi Yang Sui Junichi Nabekura Koichi Sato Fumikazu Okajima Hirohide Takebayashi Hideyuki Okano Schuichi Koizumi
author_sort	Yosuke M. Morizawa
title	Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway
title_short	Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway
title_full	Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway
title_fullStr	Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway
title_full_unstemmed	Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway
title_sort	reactive astrocytes function as phagocytes after brain ischemia via abca1-mediated pathway
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ae5888d09dbf4fd4aac1a32a1f9621b4
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Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway

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