Phylogeorgaphy of Mycobacterium tuberculosis in central and border Mongolia

The distribution of Mycobacterium tuberculosis and scope of tuberculosis morbidity in the world are extremely considerable. Among regions with high burden of tuberculosis (according to the World Health Organization data for 2015) Mongolia is one of the most disadvantaged countries. This research was...

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Autores principales:	E. A. Orlova, M. V. Badleeva, E. .. Baasansuren, N. .. Erdenegerel, T. .. Oyuuntuyaa, B. .. Buyankhishig, B. .. Puntsag, D. .. Nyamkhuu, S. N. Zhdanova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	mycobacterium tuberculosis miru-vntr beijing lineage phylogeography genetic diversity tuberculosis in mongolia Science Q
Acceso en línea:	https://doaj.org/article/ae5bcb4adcfc419aaddb69f47ad07c50
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spelling	oai:doaj.org-article:ae5bcb4adcfc419aaddb69f47ad07c502021-11-23T06:14:38ZPhylogeorgaphy of Mycobacterium tuberculosis in central and border Mongolia2541-94202587-959610.12737/article_59e85b75b4a0e9.62539831https://doaj.org/article/ae5bcb4adcfc419aaddb69f47ad07c502017-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/453https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The distribution of Mycobacterium tuberculosis and scope of tuberculosis morbidity in the world are extremely considerable. Among regions with high burden of tuberculosis (according to the World Health Organization data for 2015) Mongolia is one of the most disadvantaged countries. This research was continuation of studying of phylogenetic structure of M. tuberculosis for the determination of evolutionary and migration processes in pathogen's northeastern population and was devoted to the study of the spatial distribution of epidemically significant genotypes and subtypes, circulating in central and border (northern and southern) Mongolia. The DNAs of 309 clinical isolates of the pathogen were genotyped by the 24-locus MIRU-VNTR and LSP methods. Strains of the Beijing lineage were additionally analyzed for the presence of specific SNPs and its 24-MIRU-VNTR profiles were compared with reference database of M. Merker et al. (2015). The study indicated significant predominance of strains of the Beijing lineage (subtype CC4). This genotype is characterized by high frequency of clustering, which indicates its epidemic danger and the relatively recent introduction of «successful» strains into the territory of Mongolia. Also, a relatively homogeneous distribution structure of genotypes and subtypes of the pathogen was revealed within the studied region, which differs from the structure of the Russian population of M. tuberculosis by its subtypical composition. Thus, we assuming that CC4-strains of the Beijing lineage spread into Mongolia from neighboring East Asian regions, most likely from the Northern provinces of China (Inner Mongolia) or nearest neighboring countries of Southeast Asia.E. A. OrlovaM. V. BadleevaE. .. BaasansurenN. .. ErdenegerelT. .. OyuuntuyaaB. .. BuyankhishigB. .. PuntsagD. .. NyamkhuuS. N. ZhdanovaScientific Сentre for Family Health and Human Reproduction Problemsarticlemycobacterium tuberculosismiru-vntrmycobacterium tuberculosismiru-vntrbeijing lineagephylogeographygenetic diversitytuberculosis in mongoliaScienceQRUActa Biomedica Scientifica, Vol 2, Iss 5(1), Pp 180-185 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	mycobacterium tuberculosis miru-vntr mycobacterium tuberculosis miru-vntr beijing lineage phylogeography genetic diversity tuberculosis in mongolia Science Q
spellingShingle	mycobacterium tuberculosis miru-vntr mycobacterium tuberculosis miru-vntr beijing lineage phylogeography genetic diversity tuberculosis in mongolia Science Q E. A. Orlova M. V. Badleeva E. .. Baasansuren N. .. Erdenegerel T. .. Oyuuntuyaa B. .. Buyankhishig B. .. Puntsag D. .. Nyamkhuu S. N. Zhdanova Phylogeorgaphy of Mycobacterium tuberculosis in central and border Mongolia
description	The distribution of Mycobacterium tuberculosis and scope of tuberculosis morbidity in the world are extremely considerable. Among regions with high burden of tuberculosis (according to the World Health Organization data for 2015) Mongolia is one of the most disadvantaged countries. This research was continuation of studying of phylogenetic structure of M. tuberculosis for the determination of evolutionary and migration processes in pathogen's northeastern population and was devoted to the study of the spatial distribution of epidemically significant genotypes and subtypes, circulating in central and border (northern and southern) Mongolia. The DNAs of 309 clinical isolates of the pathogen were genotyped by the 24-locus MIRU-VNTR and LSP methods. Strains of the Beijing lineage were additionally analyzed for the presence of specific SNPs and its 24-MIRU-VNTR profiles were compared with reference database of M. Merker et al. (2015). The study indicated significant predominance of strains of the Beijing lineage (subtype CC4). This genotype is characterized by high frequency of clustering, which indicates its epidemic danger and the relatively recent introduction of «successful» strains into the territory of Mongolia. Also, a relatively homogeneous distribution structure of genotypes and subtypes of the pathogen was revealed within the studied region, which differs from the structure of the Russian population of M. tuberculosis by its subtypical composition. Thus, we assuming that CC4-strains of the Beijing lineage spread into Mongolia from neighboring East Asian regions, most likely from the Northern provinces of China (Inner Mongolia) or nearest neighboring countries of Southeast Asia.
format	article
author	E. A. Orlova M. V. Badleeva E. .. Baasansuren N. .. Erdenegerel T. .. Oyuuntuyaa B. .. Buyankhishig B. .. Puntsag D. .. Nyamkhuu S. N. Zhdanova
author_facet	E. A. Orlova M. V. Badleeva E. .. Baasansuren N. .. Erdenegerel T. .. Oyuuntuyaa B. .. Buyankhishig B. .. Puntsag D. .. Nyamkhuu S. N. Zhdanova
author_sort	E. A. Orlova
title	Phylogeorgaphy of Mycobacterium tuberculosis in central and border Mongolia
title_short	Phylogeorgaphy of Mycobacterium tuberculosis in central and border Mongolia
title_full	Phylogeorgaphy of Mycobacterium tuberculosis in central and border Mongolia
title_fullStr	Phylogeorgaphy of Mycobacterium tuberculosis in central and border Mongolia
title_full_unstemmed	Phylogeorgaphy of Mycobacterium tuberculosis in central and border Mongolia
title_sort	phylogeorgaphy of mycobacterium tuberculosis in central and border mongolia
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/ae5bcb4adcfc419aaddb69f47ad07c50
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_version_	1718417027407806464

Phylogeorgaphy of Mycobacterium tuberculosis in central and border Mongolia

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