Electroacupuncture could balance the gut microbiota and improve the learning and memory abilities of Alzheimer's disease animal model.

Alzheimer's disease (AD), as one of most common dementia, mainly affects older people from the worldwide. In this study, we intended to explore the possible mechanism of improving cognitive function and protecting the neuron effect by electroacupuncture.<h4>Method</h4>We applied sen...

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Autores principales:	Jing Jiang, Hao Liu, Zidong Wang, Huiling Tian, Shun Wang, Jiayi Yang, Jingyu Ren
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ae5e145fe3414ef0baca2c00bc903a44
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spelling	oai:doaj.org-article:ae5e145fe3414ef0baca2c00bc903a442021-12-02T20:05:57ZElectroacupuncture could balance the gut microbiota and improve the learning and memory abilities of Alzheimer's disease animal model.1932-620310.1371/journal.pone.0259530https://doaj.org/article/ae5e145fe3414ef0baca2c00bc903a442021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259530https://doaj.org/toc/1932-6203Alzheimer's disease (AD), as one of most common dementia, mainly affects older people from the worldwide. In this study, we intended to explore the possible mechanism of improving cognitive function and protecting the neuron effect by electroacupuncture.<h4>Method</h4>We applied senescence-accelerated mouse prone 8 (SAMP8) mice as AD animal model, used Morris water maze, HE staining, 16S rDNA amplicon sequencing of gut microbiota and ELISA to demonstrate our hypothesis.<h4>Results</h4>electroacupuncture improved the learning and memory abilities in SAMP8 mice (P<0.05) and could protect the frontal lobe cortex and hippocampus of SAMP8 mice; electroacupuncture significantly decreased the expression of IL-1β (P<0.01), IL-6 (P<0.01) and TNF-α (P<0.01 in hippocampus, P<0.05 in serum) in serum and hippocampus; electroacupuncture balanced the quantity and composition of gut microbiome, especially of the relative abundance in Delta-proteobacteria (P<0.05) and Epsilon-proteobacteria (P<0.05).<h4>Conclusion</h4>electroacupuncture treatment could inhibit the peripheral and central nerve system inflammatory response by balancing the gut microbiota.Jing JiangHao LiuZidong WangHuiling TianShun WangJiayi YangJingyu RenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0259530 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jing Jiang Hao Liu Zidong Wang Huiling Tian Shun Wang Jiayi Yang Jingyu Ren Electroacupuncture could balance the gut microbiota and improve the learning and memory abilities of Alzheimer's disease animal model.
description	Alzheimer's disease (AD), as one of most common dementia, mainly affects older people from the worldwide. In this study, we intended to explore the possible mechanism of improving cognitive function and protecting the neuron effect by electroacupuncture.<h4>Method</h4>We applied senescence-accelerated mouse prone 8 (SAMP8) mice as AD animal model, used Morris water maze, HE staining, 16S rDNA amplicon sequencing of gut microbiota and ELISA to demonstrate our hypothesis.<h4>Results</h4>electroacupuncture improved the learning and memory abilities in SAMP8 mice (P<0.05) and could protect the frontal lobe cortex and hippocampus of SAMP8 mice; electroacupuncture significantly decreased the expression of IL-1β (P<0.01), IL-6 (P<0.01) and TNF-α (P<0.01 in hippocampus, P<0.05 in serum) in serum and hippocampus; electroacupuncture balanced the quantity and composition of gut microbiome, especially of the relative abundance in Delta-proteobacteria (P<0.05) and Epsilon-proteobacteria (P<0.05).<h4>Conclusion</h4>electroacupuncture treatment could inhibit the peripheral and central nerve system inflammatory response by balancing the gut microbiota.
format	article
author	Jing Jiang Hao Liu Zidong Wang Huiling Tian Shun Wang Jiayi Yang Jingyu Ren
author_facet	Jing Jiang Hao Liu Zidong Wang Huiling Tian Shun Wang Jiayi Yang Jingyu Ren
author_sort	Jing Jiang
title	Electroacupuncture could balance the gut microbiota and improve the learning and memory abilities of Alzheimer's disease animal model.
title_short	Electroacupuncture could balance the gut microbiota and improve the learning and memory abilities of Alzheimer's disease animal model.
title_full	Electroacupuncture could balance the gut microbiota and improve the learning and memory abilities of Alzheimer's disease animal model.
title_fullStr	Electroacupuncture could balance the gut microbiota and improve the learning and memory abilities of Alzheimer's disease animal model.
title_full_unstemmed	Electroacupuncture could balance the gut microbiota and improve the learning and memory abilities of Alzheimer's disease animal model.
title_sort	electroacupuncture could balance the gut microbiota and improve the learning and memory abilities of alzheimer's disease animal model.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/ae5e145fe3414ef0baca2c00bc903a44
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Electroacupuncture could balance the gut microbiota and improve the learning and memory abilities of Alzheimer's disease animal model.

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