THE ASSOCIATION OF IMMUNE RESPONSE TO XENOAND ENDOBIOTIKS AND THEIRS BIOTRANSFORMATION ENZYME GENE POLYMORPHISM WITH CONGENITAL MALFORMATIONS OF THE FETUS

THE ASSOCIATION OF IMMUNE RESPONSE TO XENOAND ENDOBIOTIKS AND THEIRS BIOTRANSFORMATION ENZYME GENE POLYMORPHISM WITH CONGENITAL MALFORMATIONS OF THE FETUS

The correlation between immune response to benzo(a)pyrene and progesterone in combination with detoxification enzyme gene polymorphism (CYPIA2*1F and GSTTI) and the occurrence of congenital malformations of the fetus was revealed. It is shown that at high ratio of IgA-antibodies to benzo(a)pyrene an...

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Autores principales: K. S. Krasilnikova, E. G. Polenok, T. P. Anosova, M. P. Anosov, L. A. Gordeyeva, O. A. Glushkova, O. S. Popova, I. V. Shatalina, M. V. Kostyanko, L. S. Raving, A. N. Glushkov
Formato: article
Lenguaje:RU
Publicado: Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:
antibodies to benzo(a)pyrene
a genetic polymorphism
congenital fetal malformations
Science
Q
Acceso en línea:https://doaj.org/article/ae5e999521b44a0d8f1fb64e51870eee
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spelling oai:doaj.org-article:ae5e999521b44a0d8f1fb64e51870eee2021-11-23T06:14:19ZTHE ASSOCIATION OF IMMUNE RESPONSE TO XENOAND ENDOBIOTIKS AND THEIRS BIOTRANSFORMATION ENZYME GENE POLYMORPHISM WITH CONGENITAL MALFORMATIONS OF THE FETUS2541-94202587-9596https://doaj.org/article/ae5e999521b44a0d8f1fb64e51870eee2012-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/894https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The correlation between immune response to benzo(a)pyrene and progesterone in combination with detoxification enzyme gene polymorphism (CYPIA2*1F and GSTTI) and the occurrence of congenital malformations of the fetus was revealed. It is shown that at high ratio of IgA-antibodies to benzo(a)pyrene and to progesterone in conjunction with the mutant allele of the gene CYPIA2*1F and the deletion genotype of the gene GSTTI chance of the reproductive pathology developing increases to 41 times.K. S. KrasilnikovaE. G. PolenokT. P. AnosovaM. P. AnosovL. A. GordeyevaO. A. GlushkovaO. S. PopovaI. V. ShatalinaM. V. KostyankoL. S. RavingA. N. GlushkovScientific Сentre for Family Health and Human Reproduction Problemsarticleantibodies to benzo(a)pyrenea genetic polymorphismcongenital fetal malformationsScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 96-99 (2012)
institution DOAJ
collection DOAJ
language RU
topic antibodies to benzo(a)pyrene
a genetic polymorphism
congenital fetal malformations
Science
Q
spellingShingle antibodies to benzo(a)pyrene
a genetic polymorphism
congenital fetal malformations
Science
Q
K. S. Krasilnikova
E. G. Polenok
T. P. Anosova
M. P. Anosov
L. A. Gordeyeva
O. A. Glushkova
O. S. Popova
I. V. Shatalina
M. V. Kostyanko
L. S. Raving
A. N. Glushkov
THE ASSOCIATION OF IMMUNE RESPONSE TO XENOAND ENDOBIOTIKS AND THEIRS BIOTRANSFORMATION ENZYME GENE POLYMORPHISM WITH CONGENITAL MALFORMATIONS OF THE FETUS
description The correlation between immune response to benzo(a)pyrene and progesterone in combination with detoxification enzyme gene polymorphism (CYPIA2*1F and GSTTI) and the occurrence of congenital malformations of the fetus was revealed. It is shown that at high ratio of IgA-antibodies to benzo(a)pyrene and to progesterone in conjunction with the mutant allele of the gene CYPIA2*1F and the deletion genotype of the gene GSTTI chance of the reproductive pathology developing increases to 41 times.
format article
author K. S. Krasilnikova
E. G. Polenok
T. P. Anosova
M. P. Anosov
L. A. Gordeyeva
O. A. Glushkova
O. S. Popova
I. V. Shatalina
M. V. Kostyanko
L. S. Raving
A. N. Glushkov
author_facet K. S. Krasilnikova
E. G. Polenok
T. P. Anosova
M. P. Anosov
L. A. Gordeyeva
O. A. Glushkova
O. S. Popova
I. V. Shatalina
M. V. Kostyanko
L. S. Raving
A. N. Glushkov
author_sort K. S. Krasilnikova
title THE ASSOCIATION OF IMMUNE RESPONSE TO XENOAND ENDOBIOTIKS AND THEIRS BIOTRANSFORMATION ENZYME GENE POLYMORPHISM WITH CONGENITAL MALFORMATIONS OF THE FETUS
title_short THE ASSOCIATION OF IMMUNE RESPONSE TO XENOAND ENDOBIOTIKS AND THEIRS BIOTRANSFORMATION ENZYME GENE POLYMORPHISM WITH CONGENITAL MALFORMATIONS OF THE FETUS
title_full THE ASSOCIATION OF IMMUNE RESPONSE TO XENOAND ENDOBIOTIKS AND THEIRS BIOTRANSFORMATION ENZYME GENE POLYMORPHISM WITH CONGENITAL MALFORMATIONS OF THE FETUS
title_fullStr THE ASSOCIATION OF IMMUNE RESPONSE TO XENOAND ENDOBIOTIKS AND THEIRS BIOTRANSFORMATION ENZYME GENE POLYMORPHISM WITH CONGENITAL MALFORMATIONS OF THE FETUS
title_full_unstemmed THE ASSOCIATION OF IMMUNE RESPONSE TO XENOAND ENDOBIOTIKS AND THEIRS BIOTRANSFORMATION ENZYME GENE POLYMORPHISM WITH CONGENITAL MALFORMATIONS OF THE FETUS
title_sort association of immune response to xenoand endobiotiks and theirs biotransformation enzyme gene polymorphism with congenital malformations of the fetus
publisher Scientific Сentre for Family Health and Human Reproduction Problems
publishDate 2012
url https://doaj.org/article/ae5e999521b44a0d8f1fb64e51870eee
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