B Lymphocyte-Deficiency in Mice Causes Vascular Dysfunction by Inducing Neutrophilia
B lymphocytes have been implicated in the development of insulin resistance, atherosclerosis and certain types of hypertension. In contrast to these studies, which were performed under pathological conditions, the present study provides evidence for the protective effect of B lymphocytes in maintain...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/ae5f35f2a9c24aa0be52938250a875bd |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:ae5f35f2a9c24aa0be52938250a875bd |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:ae5f35f2a9c24aa0be52938250a875bd2021-11-25T16:50:49ZB Lymphocyte-Deficiency in Mice Causes Vascular Dysfunction by Inducing Neutrophilia10.3390/biomedicines91116862227-9059https://doaj.org/article/ae5f35f2a9c24aa0be52938250a875bd2021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1686https://doaj.org/toc/2227-9059B lymphocytes have been implicated in the development of insulin resistance, atherosclerosis and certain types of hypertension. In contrast to these studies, which were performed under pathological conditions, the present study provides evidence for the protective effect of B lymphocytes in maintaining vascular homeostasis under physiological conditions. In young mice not exposed to any known risk factors, the lack of B cells led to massive endothelial dysfunction. The vascular dysfunction in B cell-deficient mice was associated with an increased number of neutrophils in the circulating blood. Neutrophil depletion in B cell-deficient mice resulted in the complete normalization of vascular function, indicating a causal role of neutrophilia. Moreover, vascular function in B cell-deficient mice could be restored by adoptive transfer of naive B-1 cells isolated from wild-type mice. Interestingly, B-1 cell transfer also reduced the number of neutrophils in the recipient mice, further supporting the involvement of neutrophils in the vascular pathology caused by B cell-deficiency. In conclusion, we report in the present study the hitherto undescribed role of B lymphocytes in regulating vascular function. B cell dysregulation may represent a crucial mechanism in vascular pathology.Ning XiaSolveig HasselwanderGisela ReifenbergAlice HabermeierEllen I. ClossMaximilian MimmlerRebecca JungSusanne KarbachJérémy LagrangePhilip WenzelAndreas DaiberThomas MünzelNadine HövelmeyerAri WaismanHuige LiMDPI AGarticleB lymphocytesvascular functionneutrophil granulocytesnitric oxideBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1686, p 1686 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
B lymphocytes vascular function neutrophil granulocytes nitric oxide Biology (General) QH301-705.5 |
| spellingShingle |
B lymphocytes vascular function neutrophil granulocytes nitric oxide Biology (General) QH301-705.5 Ning Xia Solveig Hasselwander Gisela Reifenberg Alice Habermeier Ellen I. Closs Maximilian Mimmler Rebecca Jung Susanne Karbach Jérémy Lagrange Philip Wenzel Andreas Daiber Thomas Münzel Nadine Hövelmeyer Ari Waisman Huige Li B Lymphocyte-Deficiency in Mice Causes Vascular Dysfunction by Inducing Neutrophilia |
| description |
B lymphocytes have been implicated in the development of insulin resistance, atherosclerosis and certain types of hypertension. In contrast to these studies, which were performed under pathological conditions, the present study provides evidence for the protective effect of B lymphocytes in maintaining vascular homeostasis under physiological conditions. In young mice not exposed to any known risk factors, the lack of B cells led to massive endothelial dysfunction. The vascular dysfunction in B cell-deficient mice was associated with an increased number of neutrophils in the circulating blood. Neutrophil depletion in B cell-deficient mice resulted in the complete normalization of vascular function, indicating a causal role of neutrophilia. Moreover, vascular function in B cell-deficient mice could be restored by adoptive transfer of naive B-1 cells isolated from wild-type mice. Interestingly, B-1 cell transfer also reduced the number of neutrophils in the recipient mice, further supporting the involvement of neutrophils in the vascular pathology caused by B cell-deficiency. In conclusion, we report in the present study the hitherto undescribed role of B lymphocytes in regulating vascular function. B cell dysregulation may represent a crucial mechanism in vascular pathology. |
| format |
article |
| author |
Ning Xia Solveig Hasselwander Gisela Reifenberg Alice Habermeier Ellen I. Closs Maximilian Mimmler Rebecca Jung Susanne Karbach Jérémy Lagrange Philip Wenzel Andreas Daiber Thomas Münzel Nadine Hövelmeyer Ari Waisman Huige Li |
| author_facet |
Ning Xia Solveig Hasselwander Gisela Reifenberg Alice Habermeier Ellen I. Closs Maximilian Mimmler Rebecca Jung Susanne Karbach Jérémy Lagrange Philip Wenzel Andreas Daiber Thomas Münzel Nadine Hövelmeyer Ari Waisman Huige Li |
| author_sort |
Ning Xia |
| title |
B Lymphocyte-Deficiency in Mice Causes Vascular Dysfunction by Inducing Neutrophilia |
| title_short |
B Lymphocyte-Deficiency in Mice Causes Vascular Dysfunction by Inducing Neutrophilia |
| title_full |
B Lymphocyte-Deficiency in Mice Causes Vascular Dysfunction by Inducing Neutrophilia |
| title_fullStr |
B Lymphocyte-Deficiency in Mice Causes Vascular Dysfunction by Inducing Neutrophilia |
| title_full_unstemmed |
B Lymphocyte-Deficiency in Mice Causes Vascular Dysfunction by Inducing Neutrophilia |
| title_sort |
b lymphocyte-deficiency in mice causes vascular dysfunction by inducing neutrophilia |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/ae5f35f2a9c24aa0be52938250a875bd |
| work_keys_str_mv |
AT ningxia blymphocytedeficiencyinmicecausesvasculardysfunctionbyinducingneutrophilia AT solveighasselwander blymphocytedeficiencyinmicecausesvasculardysfunctionbyinducingneutrophilia AT giselareifenberg blymphocytedeficiencyinmicecausesvasculardysfunctionbyinducingneutrophilia AT alicehabermeier blymphocytedeficiencyinmicecausesvasculardysfunctionbyinducingneutrophilia AT ellenicloss blymphocytedeficiencyinmicecausesvasculardysfunctionbyinducingneutrophilia AT maximilianmimmler blymphocytedeficiencyinmicecausesvasculardysfunctionbyinducingneutrophilia AT rebeccajung blymphocytedeficiencyinmicecausesvasculardysfunctionbyinducingneutrophilia AT susannekarbach blymphocytedeficiencyinmicecausesvasculardysfunctionbyinducingneutrophilia AT jeremylagrange blymphocytedeficiencyinmicecausesvasculardysfunctionbyinducingneutrophilia AT philipwenzel blymphocytedeficiencyinmicecausesvasculardysfunctionbyinducingneutrophilia AT andreasdaiber blymphocytedeficiencyinmicecausesvasculardysfunctionbyinducingneutrophilia AT thomasmunzel blymphocytedeficiencyinmicecausesvasculardysfunctionbyinducingneutrophilia AT nadinehovelmeyer blymphocytedeficiencyinmicecausesvasculardysfunctionbyinducingneutrophilia AT ariwaisman blymphocytedeficiencyinmicecausesvasculardysfunctionbyinducingneutrophilia AT huigeli blymphocytedeficiencyinmicecausesvasculardysfunctionbyinducingneutrophilia |
| _version_ |
1718412916185628672 |