Adiponectin gene polymorphisms and risk of type 2 diabetes: an updated evidence for meta-analysis

Highlights Adiponectin (ADIPOQ) plays an important role in the development of type 2 diabetes and previous studies regarding the association between ADIPOQ polymorphisms and T2D risk reported conflicting results. We performed a meta-analysis to assess the association between two ADIPOQ polymorphisms...

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Autores principales:	Mahrokh Alimi, Mohammad Taghi Goodarzi, Mehdi Nekoei
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Adiponectin Type 2 diabetes SNP − 11377 SNP + 276 Single nucleotide polymorphism Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/ae5fbfd3091244369700ddfd90b212d7
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spelling	oai:doaj.org-article:ae5fbfd3091244369700ddfd90b212d72021-11-21T12:40:14ZAdiponectin gene polymorphisms and risk of type 2 diabetes: an updated evidence for meta-analysis10.1186/s13098-021-00749-x1758-5996https://doaj.org/article/ae5fbfd3091244369700ddfd90b212d72021-11-01T00:00:00Zhttps://doi.org/10.1186/s13098-021-00749-xhttps://doaj.org/toc/1758-5996Highlights Adiponectin (ADIPOQ) plays an important role in the development of type 2 diabetes and previous studies regarding the association between ADIPOQ polymorphisms and T2D risk reported conflicting results. We performed a meta-analysis to assess the association between two ADIPOQ polymorphisms [− 11377C/G (rs266729), and +276G/T (rs1501299)] and risk for T2D. Odds ratios (ORs) with corresponding 95% confidence intervals (95% CIs) were pooled to assess the association between four aforementioned polymorphisms and susceptibility to T2D. Overall, there was an association between ADIPOQ +276 G > T with increased T2D risk. Subgroup by ethnicity suggested significant association between +276G/T polymorphism and T2D risk among European ethnicities. Our findings evidence a positive association between ADIPOQ +276 G > T polymorphism with increased risk of T2D in male individuals with European ethnicity.Mahrokh AlimiMohammad Taghi GoodarziMehdi NekoeiBMCarticleAdiponectinType 2 diabetesSNP − 11377SNP + 276Single nucleotide polymorphismNutritional diseases. Deficiency diseasesRC620-627ENDiabetology & Metabolic Syndrome, Vol 13, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Adiponectin Type 2 diabetes SNP − 11377 SNP + 276 Single nucleotide polymorphism Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	Adiponectin Type 2 diabetes SNP − 11377 SNP + 276 Single nucleotide polymorphism Nutritional diseases. Deficiency diseases RC620-627 Mahrokh Alimi Mohammad Taghi Goodarzi Mehdi Nekoei Adiponectin gene polymorphisms and risk of type 2 diabetes: an updated evidence for meta-analysis
description	Highlights Adiponectin (ADIPOQ) plays an important role in the development of type 2 diabetes and previous studies regarding the association between ADIPOQ polymorphisms and T2D risk reported conflicting results. We performed a meta-analysis to assess the association between two ADIPOQ polymorphisms [− 11377C/G (rs266729), and +276G/T (rs1501299)] and risk for T2D. Odds ratios (ORs) with corresponding 95% confidence intervals (95% CIs) were pooled to assess the association between four aforementioned polymorphisms and susceptibility to T2D. Overall, there was an association between ADIPOQ +276 G > T with increased T2D risk. Subgroup by ethnicity suggested significant association between +276G/T polymorphism and T2D risk among European ethnicities. Our findings evidence a positive association between ADIPOQ +276 G > T polymorphism with increased risk of T2D in male individuals with European ethnicity.
format	article
author	Mahrokh Alimi Mohammad Taghi Goodarzi Mehdi Nekoei
author_facet	Mahrokh Alimi Mohammad Taghi Goodarzi Mehdi Nekoei
author_sort	Mahrokh Alimi
title	Adiponectin gene polymorphisms and risk of type 2 diabetes: an updated evidence for meta-analysis
title_short	Adiponectin gene polymorphisms and risk of type 2 diabetes: an updated evidence for meta-analysis
title_full	Adiponectin gene polymorphisms and risk of type 2 diabetes: an updated evidence for meta-analysis
title_fullStr	Adiponectin gene polymorphisms and risk of type 2 diabetes: an updated evidence for meta-analysis
title_full_unstemmed	Adiponectin gene polymorphisms and risk of type 2 diabetes: an updated evidence for meta-analysis
title_sort	adiponectin gene polymorphisms and risk of type 2 diabetes: an updated evidence for meta-analysis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/ae5fbfd3091244369700ddfd90b212d7
work_keys_str_mv	AT mahrokhalimi adiponectingenepolymorphismsandriskoftype2diabetesanupdatedevidenceformetaanalysis AT mohammadtaghigoodarzi adiponectingenepolymorphismsandriskoftype2diabetesanupdatedevidenceformetaanalysis AT mehdinekoei adiponectingenepolymorphismsandriskoftype2diabetesanupdatedevidenceformetaanalysis
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Adiponectin gene polymorphisms and risk of type 2 diabetes: an updated evidence for meta-analysis

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