Early Post-Stroke Electroacupuncture Promotes Motor Function Recovery in Post-Ischemic Rats by Increasing the Blood and Brain Irisin

Li Liu,1,* Qun Zhang,1,* Mingyue Li,2 Nianhong Wang,1 Ce Li,1 Di Song,3 Xueyan Shen,1 Lu Luo,1 Yunhui Fan,1 Hongyu Xie,1 Yi Wu1 1Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China; 2Department of Rehabilitation Medicine, The Thir...

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Autores principales:	Liu L, Zhang Q, Li M, Wang N, Li C, Song D, Shen X, Luo L, Fan Y, Xie H, Wu Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	ischemic stroke electroacupuncture irisin; Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/ae6068b01fd549bab8d6ee5c5497faa0
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spelling	oai:doaj.org-article:ae6068b01fd549bab8d6ee5c5497faa02021-12-02T14:32:47ZEarly Post-Stroke Electroacupuncture Promotes Motor Function Recovery in Post-Ischemic Rats by Increasing the Blood and Brain Irisin1178-2021https://doaj.org/article/ae6068b01fd549bab8d6ee5c5497faa02021-03-01T00:00:00Zhttps://www.dovepress.com/early-post-stroke-electroacupuncture-promotes-motor-function-recovery--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Li Liu,1,* Qun Zhang,1,* Mingyue Li,2 Nianhong Wang,1 Ce Li,1 Di Song,3 Xueyan Shen,1 Lu Luo,1 Yunhui Fan,1 Hongyu Xie,1 Yi Wu1 1Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China; 2Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China; 3Department of Rehabilitation Medicine, The Affiliated Sixth People’s Hospital of Shanghai Jiaotong University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongyu Xie; Yi WuDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai, 200040, People’s Republic of ChinaEmail huangdaitian@163.com; 16111220064@fudan.edu.cnObjective: Recent studies have shown that irisin, a novel peptide hormone derived from muscles, could be used as a potential therapeutic drug against ischemic stroke. Moreover, electroacupuncture (EA) is widely used in the treatment of ischemic stroke. Yet, whether irisin is involved in the EA neuroprotection remains unclear. The following study investigated the association between serum and peri-lesional cortex irisin and EA-induced post-stroke motor recovery in rats.Methods: The middle cerebral artery occlusion (MCAO) method was used to induce ischemic stroke in rats. Rats were randomly divided into two groups: a middle cerebral artery occlusion (MCAO) group (MCAO rats without treatment) and an electroacupuncture (EA) group (MCAO rats treated with EA). On the 3rd day post-stroke, infarct volume, behavioral deﬁcits, surviving neurons, irisin protein expression in peri-infarction cortex, muscle tissue, and serum were evaluated to identify the neuroprotective of EA in acute ischemic stroke.Results: Compared with the MCAO group, the EA group showed better behavioral performance, a smaller cerebral infarct volume, more surviving neurons, and a significant increase in irisin expression in the peri-infarction cortex and serum (p< 0.05). However, no difference in irisin expression in the muscle tissue was found between the MCAO group and the EA group (p> 0.05).Conclusion: EA promotes motor function recovery, reduces the volume of cerebral infarction, and alleviates neuronal death following ischemic stroke by enhancing the expression of irisin in both the blood and peri-lesional cortex.Keywords: ischemic stroke, electroacupuncture, irisinLiu LZhang QLi MWang NLi CSong DShen XLuo LFan YXie HWu YDove Medical Pressarticleischemic strokeelectroacupunctureirisin;Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 695-702 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ischemic stroke electroacupuncture irisin; Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	ischemic stroke electroacupuncture irisin; Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Liu L Zhang Q Li M Wang N Li C Song D Shen X Luo L Fan Y Xie H Wu Y Early Post-Stroke Electroacupuncture Promotes Motor Function Recovery in Post-Ischemic Rats by Increasing the Blood and Brain Irisin
description	Li Liu,1,* Qun Zhang,1,* Mingyue Li,2 Nianhong Wang,1 Ce Li,1 Di Song,3 Xueyan Shen,1 Lu Luo,1 Yunhui Fan,1 Hongyu Xie,1 Yi Wu1 1Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China; 2Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China; 3Department of Rehabilitation Medicine, The Affiliated Sixth People’s Hospital of Shanghai Jiaotong University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongyu Xie; Yi WuDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai, 200040, People’s Republic of ChinaEmail huangdaitian@163.com; 16111220064@fudan.edu.cnObjective: Recent studies have shown that irisin, a novel peptide hormone derived from muscles, could be used as a potential therapeutic drug against ischemic stroke. Moreover, electroacupuncture (EA) is widely used in the treatment of ischemic stroke. Yet, whether irisin is involved in the EA neuroprotection remains unclear. The following study investigated the association between serum and peri-lesional cortex irisin and EA-induced post-stroke motor recovery in rats.Methods: The middle cerebral artery occlusion (MCAO) method was used to induce ischemic stroke in rats. Rats were randomly divided into two groups: a middle cerebral artery occlusion (MCAO) group (MCAO rats without treatment) and an electroacupuncture (EA) group (MCAO rats treated with EA). On the 3rd day post-stroke, infarct volume, behavioral deﬁcits, surviving neurons, irisin protein expression in peri-infarction cortex, muscle tissue, and serum were evaluated to identify the neuroprotective of EA in acute ischemic stroke.Results: Compared with the MCAO group, the EA group showed better behavioral performance, a smaller cerebral infarct volume, more surviving neurons, and a significant increase in irisin expression in the peri-infarction cortex and serum (p< 0.05). However, no difference in irisin expression in the muscle tissue was found between the MCAO group and the EA group (p> 0.05).Conclusion: EA promotes motor function recovery, reduces the volume of cerebral infarction, and alleviates neuronal death following ischemic stroke by enhancing the expression of irisin in both the blood and peri-lesional cortex.Keywords: ischemic stroke, electroacupuncture, irisin
format	article
author	Liu L Zhang Q Li M Wang N Li C Song D Shen X Luo L Fan Y Xie H Wu Y
author_facet	Liu L Zhang Q Li M Wang N Li C Song D Shen X Luo L Fan Y Xie H Wu Y
author_sort	Liu L
title	Early Post-Stroke Electroacupuncture Promotes Motor Function Recovery in Post-Ischemic Rats by Increasing the Blood and Brain Irisin
title_short	Early Post-Stroke Electroacupuncture Promotes Motor Function Recovery in Post-Ischemic Rats by Increasing the Blood and Brain Irisin
title_full	Early Post-Stroke Electroacupuncture Promotes Motor Function Recovery in Post-Ischemic Rats by Increasing the Blood and Brain Irisin
title_fullStr	Early Post-Stroke Electroacupuncture Promotes Motor Function Recovery in Post-Ischemic Rats by Increasing the Blood and Brain Irisin
title_full_unstemmed	Early Post-Stroke Electroacupuncture Promotes Motor Function Recovery in Post-Ischemic Rats by Increasing the Blood and Brain Irisin
title_sort	early post-stroke electroacupuncture promotes motor function recovery in post-ischemic rats by increasing the blood and brain irisin
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/ae6068b01fd549bab8d6ee5c5497faa0
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Early Post-Stroke Electroacupuncture Promotes Motor Function Recovery in Post-Ischemic Rats by Increasing the Blood and Brain Irisin

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