Possible Role of Leptin in Atopic Dermatitis: A Literature Review

Atopic dermatitis (AD) is the most frequent chronic inflammatory skin disease, and its incidence has been rapidly increasing in developed countries in the last years. AD presents a high degree of heterogeneity due to biases and confounding factors such as age range, sex, or ethnicity. For those reas...

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Autores principales:	Carlos Jiménez-Cortegana, Germán Ortiz-García, Amalia Serrano, David Moreno-Ramírez, Víctor Sánchez-Margalet
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	atopic dermatitis obesity inflammation leptin adipokine immune system Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/ae681e9fd06b40a99df80177bb6efb88
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spelling	oai:doaj.org-article:ae681e9fd06b40a99df80177bb6efb882021-11-25T16:53:18ZPossible Role of Leptin in Atopic Dermatitis: A Literature Review10.3390/biom111116422218-273Xhttps://doaj.org/article/ae681e9fd06b40a99df80177bb6efb882021-11-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1642https://doaj.org/toc/2218-273XAtopic dermatitis (AD) is the most frequent chronic inflammatory skin disease, and its incidence has been rapidly increasing in developed countries in the last years. AD presents a high degree of heterogeneity due to biases and confounding factors such as age range, sex, or ethnicity. For those reasons, the search for new biomarkers is crucial. At the same time, obesity, which is a global health problem, has also increased over the years. It has been associated with many pathophysiological states, including skin diseases such as AD, mostly in childhood. Obesity promotes a low grade inflammation driven by many different cytokines and adipokines, including leptin, which has a key role in many other diseases due to its pleiotropic effects. Leptin also has a role in both skin and allergic diseases very related to AD. Thus, this adipokine could have an important role in the pathogenesis of AD, especially in its chronicity. Despite the limited literature available, there is some evidence that leads us to consider leptin as an important adipokine in this skin disease. For this reason, here we have reviewed the role of leptin in the pathophysiology of AD.Carlos Jiménez-CorteganaGermán Ortiz-GarcíaAmalia SerranoDavid Moreno-RamírezVíctor Sánchez-MargaletMDPI AGarticleatopic dermatitisobesityinflammationleptinadipokineimmune systemMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1642, p 1642 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atopic dermatitis obesity inflammation leptin adipokine immune system Microbiology QR1-502
spellingShingle	atopic dermatitis obesity inflammation leptin adipokine immune system Microbiology QR1-502 Carlos Jiménez-Cortegana Germán Ortiz-García Amalia Serrano David Moreno-Ramírez Víctor Sánchez-Margalet Possible Role of Leptin in Atopic Dermatitis: A Literature Review
description	Atopic dermatitis (AD) is the most frequent chronic inflammatory skin disease, and its incidence has been rapidly increasing in developed countries in the last years. AD presents a high degree of heterogeneity due to biases and confounding factors such as age range, sex, or ethnicity. For those reasons, the search for new biomarkers is crucial. At the same time, obesity, which is a global health problem, has also increased over the years. It has been associated with many pathophysiological states, including skin diseases such as AD, mostly in childhood. Obesity promotes a low grade inflammation driven by many different cytokines and adipokines, including leptin, which has a key role in many other diseases due to its pleiotropic effects. Leptin also has a role in both skin and allergic diseases very related to AD. Thus, this adipokine could have an important role in the pathogenesis of AD, especially in its chronicity. Despite the limited literature available, there is some evidence that leads us to consider leptin as an important adipokine in this skin disease. For this reason, here we have reviewed the role of leptin in the pathophysiology of AD.
format	article
author	Carlos Jiménez-Cortegana Germán Ortiz-García Amalia Serrano David Moreno-Ramírez Víctor Sánchez-Margalet
author_facet	Carlos Jiménez-Cortegana Germán Ortiz-García Amalia Serrano David Moreno-Ramírez Víctor Sánchez-Margalet
author_sort	Carlos Jiménez-Cortegana
title	Possible Role of Leptin in Atopic Dermatitis: A Literature Review
title_short	Possible Role of Leptin in Atopic Dermatitis: A Literature Review
title_full	Possible Role of Leptin in Atopic Dermatitis: A Literature Review
title_fullStr	Possible Role of Leptin in Atopic Dermatitis: A Literature Review
title_full_unstemmed	Possible Role of Leptin in Atopic Dermatitis: A Literature Review
title_sort	possible role of leptin in atopic dermatitis: a literature review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ae681e9fd06b40a99df80177bb6efb88
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_version_	1718412916390100992

Possible Role of Leptin in Atopic Dermatitis: A Literature Review

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