Structural basis of mammalian mucin processing by the human gut O-glycopeptidase OgpA from Akkermansia muciniphila

OgpA is an O-glycopeptidase from Akkermansia muciniphila, a mucin-degrading bacterium commonly found in the human gut. A thorough characterization of OgpA, including crystal structures in complex with substrate or product, reveals molecular basis of O-glycan recognition and enzyme specificity.

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Autores principales:	Beatriz Trastoy, Andreas Naegeli, Itxaso Anso, Jonathan Sjögren, Marcelo E. Guerin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ae698bd6443d4047a42023b094a28689
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spelling	oai:doaj.org-article:ae698bd6443d4047a42023b094a286892021-12-02T18:14:31ZStructural basis of mammalian mucin processing by the human gut O-glycopeptidase OgpA from Akkermansia muciniphila10.1038/s41467-020-18696-y2041-1723https://doaj.org/article/ae698bd6443d4047a42023b094a286892020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18696-yhttps://doaj.org/toc/2041-1723OgpA is an O-glycopeptidase from Akkermansia muciniphila, a mucin-degrading bacterium commonly found in the human gut. A thorough characterization of OgpA, including crystal structures in complex with substrate or product, reveals molecular basis of O-glycan recognition and enzyme specificity.Beatriz TrastoyAndreas NaegeliItxaso AnsoJonathan SjögrenMarcelo E. GuerinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Beatriz Trastoy Andreas Naegeli Itxaso Anso Jonathan Sjögren Marcelo E. Guerin Structural basis of mammalian mucin processing by the human gut O-glycopeptidase OgpA from Akkermansia muciniphila
description	OgpA is an O-glycopeptidase from Akkermansia muciniphila, a mucin-degrading bacterium commonly found in the human gut. A thorough characterization of OgpA, including crystal structures in complex with substrate or product, reveals molecular basis of O-glycan recognition and enzyme specificity.
format	article
author	Beatriz Trastoy Andreas Naegeli Itxaso Anso Jonathan Sjögren Marcelo E. Guerin
author_facet	Beatriz Trastoy Andreas Naegeli Itxaso Anso Jonathan Sjögren Marcelo E. Guerin
author_sort	Beatriz Trastoy
title	Structural basis of mammalian mucin processing by the human gut O-glycopeptidase OgpA from Akkermansia muciniphila
title_short	Structural basis of mammalian mucin processing by the human gut O-glycopeptidase OgpA from Akkermansia muciniphila
title_full	Structural basis of mammalian mucin processing by the human gut O-glycopeptidase OgpA from Akkermansia muciniphila
title_fullStr	Structural basis of mammalian mucin processing by the human gut O-glycopeptidase OgpA from Akkermansia muciniphila
title_full_unstemmed	Structural basis of mammalian mucin processing by the human gut O-glycopeptidase OgpA from Akkermansia muciniphila
title_sort	structural basis of mammalian mucin processing by the human gut o-glycopeptidase ogpa from akkermansia muciniphila
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ae698bd6443d4047a42023b094a28689
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Structural basis of mammalian mucin processing by the human gut O-glycopeptidase OgpA from Akkermansia muciniphila

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