Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy.

Pre-school age children account for 10%-20% of the 2 billion people worldwide who are infected with soil-transmitted helminths (STHs): Ascaris lumbricoides (roundworm), Trichuris trichiura (whipworm), and Ancylostoma duodenale/Necator americanus (hookworms). Through a systematic review of the publis...

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Autores principales:	Marco Albonico, Henrietta Allen, Lester Chitsulo, Dirk Engels, Albis-Francesco Gabrielli, Lorenzo Savioli
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/ae6994fee4e14f698b7b652ba7e0b085
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id	oai:doaj.org-article:ae6994fee4e14f698b7b652ba7e0b085
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spelling	oai:doaj.org-article:ae6994fee4e14f698b7b652ba7e0b0852021-11-25T06:32:37ZControlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy.1935-27271935-273510.1371/journal.pntd.0000126https://doaj.org/article/ae6994fee4e14f698b7b652ba7e0b0852008-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18365031/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735Pre-school age children account for 10%-20% of the 2 billion people worldwide who are infected with soil-transmitted helminths (STHs): Ascaris lumbricoides (roundworm), Trichuris trichiura (whipworm), and Ancylostoma duodenale/Necator americanus (hookworms). Through a systematic review of the published literature and using information collated at World Health Organization headquarters, this paper summarizes the available evidence to support the recommendation that pre-school children should be included in regular deworming programmes. The first section describes the burden of STH disease in this age group, followed by a summary of how infection impacts iron status, growth, vitamin A status, and cognitive development and how STHs may exacerbate other high mortality infections. The second section explores the safety of the drugs themselves, given alone or co-administered, drug efficacy, and the importance of safe administration. The third section provides country-based evidence to demonstrate improved health outcomes after STH treatment. The final section provides country experiences in scaling up coverage of pre-school children by using other large scale public health interventions, including vitamin A programmes, immunization campaigns, and Child Health days. The paper concludes with a number of open research questions and a summary of some of the operational challenges that still need to be addressed.Marco AlbonicoHenrietta AllenLester ChitsuloDirk EngelsAlbis-Francesco GabrielliLorenzo SavioliPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 2, Iss 3, p e126 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Marco Albonico Henrietta Allen Lester Chitsulo Dirk Engels Albis-Francesco Gabrielli Lorenzo Savioli Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy.
description	Pre-school age children account for 10%-20% of the 2 billion people worldwide who are infected with soil-transmitted helminths (STHs): Ascaris lumbricoides (roundworm), Trichuris trichiura (whipworm), and Ancylostoma duodenale/Necator americanus (hookworms). Through a systematic review of the published literature and using information collated at World Health Organization headquarters, this paper summarizes the available evidence to support the recommendation that pre-school children should be included in regular deworming programmes. The first section describes the burden of STH disease in this age group, followed by a summary of how infection impacts iron status, growth, vitamin A status, and cognitive development and how STHs may exacerbate other high mortality infections. The second section explores the safety of the drugs themselves, given alone or co-administered, drug efficacy, and the importance of safe administration. The third section provides country-based evidence to demonstrate improved health outcomes after STH treatment. The final section provides country experiences in scaling up coverage of pre-school children by using other large scale public health interventions, including vitamin A programmes, immunization campaigns, and Child Health days. The paper concludes with a number of open research questions and a summary of some of the operational challenges that still need to be addressed.
format	article
author	Marco Albonico Henrietta Allen Lester Chitsulo Dirk Engels Albis-Francesco Gabrielli Lorenzo Savioli
author_facet	Marco Albonico Henrietta Allen Lester Chitsulo Dirk Engels Albis-Francesco Gabrielli Lorenzo Savioli
author_sort	Marco Albonico
title	Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy.
title_short	Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy.
title_full	Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy.
title_fullStr	Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy.
title_full_unstemmed	Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy.
title_sort	controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/ae6994fee4e14f698b7b652ba7e0b085
work_keys_str_mv	AT marcoalbonico controllingsoiltransmittedhelminthiasisinpreschoolagechildrenthroughpreventivechemotherapy AT henriettaallen controllingsoiltransmittedhelminthiasisinpreschoolagechildrenthroughpreventivechemotherapy AT lesterchitsulo controllingsoiltransmittedhelminthiasisinpreschoolagechildrenthroughpreventivechemotherapy AT dirkengels controllingsoiltransmittedhelminthiasisinpreschoolagechildrenthroughpreventivechemotherapy AT albisfrancescogabrielli controllingsoiltransmittedhelminthiasisinpreschoolagechildrenthroughpreventivechemotherapy AT lorenzosavioli controllingsoiltransmittedhelminthiasisinpreschoolagechildrenthroughpreventivechemotherapy
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Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy.

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