Role of rs1143634 (+3954C>T) polymorphism in cancer risk: an updated meta-analysis and trial sequential analysis

Objective Oxidative stress caused by the pro-inflammatory cytokine interleukin (IL)-1β has been widely investigated for cancer risk. In this study, we focused on the role of IL-1β rs1143634 polymorphism to reveal its impact on cancer development. Methods Related studies with fixed inclusion criteria...

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Autores principales:	Sarah Jafrin, Md. Abdul Aziz, Mohammad Safiqul Islam
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ae7156c626874535999a6e37d3e2d275
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spelling	oai:doaj.org-article:ae7156c626874535999a6e37d3e2d2752021-12-04T01:03:31ZRole of rs1143634 (+3954C>T) polymorphism in cancer risk: an updated meta-analysis and trial sequential analysis1473-230010.1177/03000605211060144https://doaj.org/article/ae7156c626874535999a6e37d3e2d2752021-12-01T00:00:00Zhttps://doi.org/10.1177/03000605211060144https://doaj.org/toc/1473-2300Objective Oxidative stress caused by the pro-inflammatory cytokine interleukin (IL)-1β has been widely investigated for cancer risk. In this study, we focused on the role of IL-1β rs1143634 polymorphism to reveal its impact on cancer development. Methods Related studies with fixed inclusion criteria were selected from electronic databases to May 2021. This meta-analysis was performed with odds ratios and 95% confidence intervals. Heterogeneity, publication bias and sensitivity analyses were also conducted. Trial sequential analysis (TSA) and in - silico gene expression analysis were performed. Results Forty-four case–control studies involving 18,645 patients with cancer and 22,882 controls were included. We observed a significant association of this single nucleotide polymorphism with overall cancer risk in the codominant model 3 (1.13-fold), recessive model (1.14-fold) and allelic model (1.08-fold). Subgroup analysis revealed that rs1143634 elevated the risk of gastric cancer, breast cancer and multiple myeloma. In addition, Asian and mixed populations and hospital-based controls had a significantly higher risk of cancer development. TSA confirmed our findings. Conclusion Our meta-analysis revealed that the presence of IL-1β rs1143634 polymorphism increases the risk of cancer development. Among polymorphism carriers, the Asian population has a higher risk than other ethnic populations. This meta-analysis was registered retrospectively at INPLASY ( https://inplasy.com/ , INPLASY2021100044).Sarah JafrinMd. Abdul AzizMohammad Safiqul IslamSAGE PublishingarticleMedicine (General)R5-920ENJournal of International Medical Research, Vol 49 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Sarah Jafrin Md. Abdul Aziz Mohammad Safiqul Islam Role of rs1143634 (+3954C>T) polymorphism in cancer risk: an updated meta-analysis and trial sequential analysis
description	Objective Oxidative stress caused by the pro-inflammatory cytokine interleukin (IL)-1β has been widely investigated for cancer risk. In this study, we focused on the role of IL-1β rs1143634 polymorphism to reveal its impact on cancer development. Methods Related studies with fixed inclusion criteria were selected from electronic databases to May 2021. This meta-analysis was performed with odds ratios and 95% confidence intervals. Heterogeneity, publication bias and sensitivity analyses were also conducted. Trial sequential analysis (TSA) and in - silico gene expression analysis were performed. Results Forty-four case–control studies involving 18,645 patients with cancer and 22,882 controls were included. We observed a significant association of this single nucleotide polymorphism with overall cancer risk in the codominant model 3 (1.13-fold), recessive model (1.14-fold) and allelic model (1.08-fold). Subgroup analysis revealed that rs1143634 elevated the risk of gastric cancer, breast cancer and multiple myeloma. In addition, Asian and mixed populations and hospital-based controls had a significantly higher risk of cancer development. TSA confirmed our findings. Conclusion Our meta-analysis revealed that the presence of IL-1β rs1143634 polymorphism increases the risk of cancer development. Among polymorphism carriers, the Asian population has a higher risk than other ethnic populations. This meta-analysis was registered retrospectively at INPLASY ( https://inplasy.com/ , INPLASY2021100044).
format	article
author	Sarah Jafrin Md. Abdul Aziz Mohammad Safiqul Islam
author_facet	Sarah Jafrin Md. Abdul Aziz Mohammad Safiqul Islam
author_sort	Sarah Jafrin
title	Role of rs1143634 (+3954C>T) polymorphism in cancer risk: an updated meta-analysis and trial sequential analysis
title_short	Role of rs1143634 (+3954C>T) polymorphism in cancer risk: an updated meta-analysis and trial sequential analysis
title_full	Role of rs1143634 (+3954C>T) polymorphism in cancer risk: an updated meta-analysis and trial sequential analysis
title_fullStr	Role of rs1143634 (+3954C>T) polymorphism in cancer risk: an updated meta-analysis and trial sequential analysis
title_full_unstemmed	Role of rs1143634 (+3954C>T) polymorphism in cancer risk: an updated meta-analysis and trial sequential analysis
title_sort	role of rs1143634 (+3954c>t) polymorphism in cancer risk: an updated meta-analysis and trial sequential analysis
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/ae7156c626874535999a6e37d3e2d275
work_keys_str_mv	AT sarahjafrin roleofrs11436343954ctpolymorphismincancerriskanupdatedmetaanalysisandtrialsequentialanalysis AT mdabdulaziz roleofrs11436343954ctpolymorphismincancerriskanupdatedmetaanalysisandtrialsequentialanalysis AT mohammadsafiqulislam roleofrs11436343954ctpolymorphismincancerriskanupdatedmetaanalysisandtrialsequentialanalysis
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Role of rs1143634 (+3954C>T) polymorphism in cancer risk: an updated meta-analysis and trial sequential analysis

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