The application of genomics to emerging zoonotic viral diseases.

Interspecies transmission of pathogens may result in the emergence of new infectious diseases in humans as well as in domestic and wild animals. Genomics tools such as high-throughput sequencing, mRNA expression profiling, and microarray-based analysis of single nucleotide polymorphisms are providin...

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Autores principales:	Bart L Haagmans, Arno C Andeweg, Albert D M E Osterhaus
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ae728a6daaa14b30a7488318ded9f346
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spelling	oai:doaj.org-article:ae728a6daaa14b30a7488318ded9f3462021-11-25T05:48:33ZThe application of genomics to emerging zoonotic viral diseases.1553-73661553-737410.1371/journal.ppat.1000557https://doaj.org/article/ae728a6daaa14b30a7488318ded9f3462009-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19855817/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Interspecies transmission of pathogens may result in the emergence of new infectious diseases in humans as well as in domestic and wild animals. Genomics tools such as high-throughput sequencing, mRNA expression profiling, and microarray-based analysis of single nucleotide polymorphisms are providing unprecedented ways to analyze the diversity of the genomes of emerging pathogens as well as the molecular basis of the host response to them. By comparing and contrasting the outcomes of an emerging infection with those of closely related pathogens in different but related host species, we can further delineate the various host pathways determining the outcome of zoonotic transmission and adaptation to the newly invaded species. The ultimate challenge is to link pathogen and host genomics data with biological outcomes of zoonotic transmission and to translate the integrated data into novel intervention strategies that eventually will allow the effective control of newly emerging infectious diseases.Bart L HaagmansArno C AndewegAlbert D M E OsterhausPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 5, Iss 10, p e1000557 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Bart L Haagmans Arno C Andeweg Albert D M E Osterhaus The application of genomics to emerging zoonotic viral diseases.
description	Interspecies transmission of pathogens may result in the emergence of new infectious diseases in humans as well as in domestic and wild animals. Genomics tools such as high-throughput sequencing, mRNA expression profiling, and microarray-based analysis of single nucleotide polymorphisms are providing unprecedented ways to analyze the diversity of the genomes of emerging pathogens as well as the molecular basis of the host response to them. By comparing and contrasting the outcomes of an emerging infection with those of closely related pathogens in different but related host species, we can further delineate the various host pathways determining the outcome of zoonotic transmission and adaptation to the newly invaded species. The ultimate challenge is to link pathogen and host genomics data with biological outcomes of zoonotic transmission and to translate the integrated data into novel intervention strategies that eventually will allow the effective control of newly emerging infectious diseases.
format	article
author	Bart L Haagmans Arno C Andeweg Albert D M E Osterhaus
author_facet	Bart L Haagmans Arno C Andeweg Albert D M E Osterhaus
author_sort	Bart L Haagmans
title	The application of genomics to emerging zoonotic viral diseases.
title_short	The application of genomics to emerging zoonotic viral diseases.
title_full	The application of genomics to emerging zoonotic viral diseases.
title_fullStr	The application of genomics to emerging zoonotic viral diseases.
title_full_unstemmed	The application of genomics to emerging zoonotic viral diseases.
title_sort	application of genomics to emerging zoonotic viral diseases.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/ae728a6daaa14b30a7488318ded9f346
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The application of genomics to emerging zoonotic viral diseases.

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