Impact of left atrial appendage morphology on thrombus formation after successful left atrial appendage occlusion: Assessment with cardiac-computed-tomography

Abstract A standardized imaging algorithm by cardiac computed tomography angiography (cCTA) (LOVE-view) was used in 30 patients to evaluate the influence of different left atrial appendage (LAA) morphologies on development of thrombosis in the LAA 6 months after implantation of an occlusion device (...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wulf Dieker, Michael Behnes, Christian Fastner, Benjamin Sartorius, Annika Wenke, Ishar Sing-Gill, Ibrahim El-Battrawy, Jürgen Kuschyk, Theano Papavassiliu, Ursula Hoffmann, Kambis Mashayekhi, Stefan O. Schoenberg, Martin Borggrefe, Thomas Henzler, Ibrahim Akin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ae7540cbfe2544ac8e819fb3508db625
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ae7540cbfe2544ac8e819fb3508db625
record_format	dspace
spelling	oai:doaj.org-article:ae7540cbfe2544ac8e819fb3508db6252021-12-02T15:07:44ZImpact of left atrial appendage morphology on thrombus formation after successful left atrial appendage occlusion: Assessment with cardiac-computed-tomography10.1038/s41598-018-19385-z2045-2322https://doaj.org/article/ae7540cbfe2544ac8e819fb3508db6252018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-19385-zhttps://doaj.org/toc/2045-2322Abstract A standardized imaging algorithm by cardiac computed tomography angiography (cCTA) (LOVE-view) was used in 30 patients to evaluate the influence of different left atrial appendage (LAA) morphologies on development of thrombosis in the LAA 6 months after implantation of an occlusion device (Watchman or Amplatzer-Cardiac-Plug) in patients with non-valvular atrial fibrillation, CHA2DS2-VASc-Score >1 and a contraindication for oral anticoagulation. The distribution of different LAA morphologies was 40% windsock, 17% broccoli and 43% chicken wing type. There was no significant difference in the level of thrombosis regarding LAA morphology or the type of chosen occlusion device. The rates of complete LAA thrombosis was 40% in broccoli type, 33% in windsock and 15% in chicken wing type. Independently of LAA type, 13% had none and 60% incomplete thrombosis. The ratio of density (LA/LAA) was 0.14 in patients with complete thrombosis and 0.67 in those with none or incomplete thrombosis. cCTA and the LOVE-view-imaging-algorithm were shown to be a valuable method for standardized imaging in clinical routine in a greater set of patients. Surprisingly thrombosis of the occluded LAA was still in progress in most cases at 6 months, whereas further studies are needed defining its clinical consequences, especially for the selection of the optimal post-procedural antithrombotic treatment strategy.Wulf DiekerMichael BehnesChristian FastnerBenjamin SartoriusAnnika WenkeIshar Sing-GillIbrahim El-BattrawyJürgen KuschykTheano PapavassiliuUrsula HoffmannKambis MashayekhiStefan O. SchoenbergMartin BorggrefeThomas HenzlerIbrahim AkinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-6 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wulf Dieker Michael Behnes Christian Fastner Benjamin Sartorius Annika Wenke Ishar Sing-Gill Ibrahim El-Battrawy Jürgen Kuschyk Theano Papavassiliu Ursula Hoffmann Kambis Mashayekhi Stefan O. Schoenberg Martin Borggrefe Thomas Henzler Ibrahim Akin Impact of left atrial appendage morphology on thrombus formation after successful left atrial appendage occlusion: Assessment with cardiac-computed-tomography
description	Abstract A standardized imaging algorithm by cardiac computed tomography angiography (cCTA) (LOVE-view) was used in 30 patients to evaluate the influence of different left atrial appendage (LAA) morphologies on development of thrombosis in the LAA 6 months after implantation of an occlusion device (Watchman or Amplatzer-Cardiac-Plug) in patients with non-valvular atrial fibrillation, CHA2DS2-VASc-Score >1 and a contraindication for oral anticoagulation. The distribution of different LAA morphologies was 40% windsock, 17% broccoli and 43% chicken wing type. There was no significant difference in the level of thrombosis regarding LAA morphology or the type of chosen occlusion device. The rates of complete LAA thrombosis was 40% in broccoli type, 33% in windsock and 15% in chicken wing type. Independently of LAA type, 13% had none and 60% incomplete thrombosis. The ratio of density (LA/LAA) was 0.14 in patients with complete thrombosis and 0.67 in those with none or incomplete thrombosis. cCTA and the LOVE-view-imaging-algorithm were shown to be a valuable method for standardized imaging in clinical routine in a greater set of patients. Surprisingly thrombosis of the occluded LAA was still in progress in most cases at 6 months, whereas further studies are needed defining its clinical consequences, especially for the selection of the optimal post-procedural antithrombotic treatment strategy.
format	article
author	Wulf Dieker Michael Behnes Christian Fastner Benjamin Sartorius Annika Wenke Ishar Sing-Gill Ibrahim El-Battrawy Jürgen Kuschyk Theano Papavassiliu Ursula Hoffmann Kambis Mashayekhi Stefan O. Schoenberg Martin Borggrefe Thomas Henzler Ibrahim Akin
author_facet	Wulf Dieker Michael Behnes Christian Fastner Benjamin Sartorius Annika Wenke Ishar Sing-Gill Ibrahim El-Battrawy Jürgen Kuschyk Theano Papavassiliu Ursula Hoffmann Kambis Mashayekhi Stefan O. Schoenberg Martin Borggrefe Thomas Henzler Ibrahim Akin
author_sort	Wulf Dieker
title	Impact of left atrial appendage morphology on thrombus formation after successful left atrial appendage occlusion: Assessment with cardiac-computed-tomography
title_short	Impact of left atrial appendage morphology on thrombus formation after successful left atrial appendage occlusion: Assessment with cardiac-computed-tomography
title_full	Impact of left atrial appendage morphology on thrombus formation after successful left atrial appendage occlusion: Assessment with cardiac-computed-tomography
title_fullStr	Impact of left atrial appendage morphology on thrombus formation after successful left atrial appendage occlusion: Assessment with cardiac-computed-tomography
title_full_unstemmed	Impact of left atrial appendage morphology on thrombus formation after successful left atrial appendage occlusion: Assessment with cardiac-computed-tomography
title_sort	impact of left atrial appendage morphology on thrombus formation after successful left atrial appendage occlusion: assessment with cardiac-computed-tomography
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ae7540cbfe2544ac8e819fb3508db625
work_keys_str_mv	AT wulfdieker impactofleftatrialappendagemorphologyonthrombusformationaftersuccessfulleftatrialappendageocclusionassessmentwithcardiaccomputedtomography AT michaelbehnes impactofleftatrialappendagemorphologyonthrombusformationaftersuccessfulleftatrialappendageocclusionassessmentwithcardiaccomputedtomography AT christianfastner impactofleftatrialappendagemorphologyonthrombusformationaftersuccessfulleftatrialappendageocclusionassessmentwithcardiaccomputedtomography AT benjaminsartorius impactofleftatrialappendagemorphologyonthrombusformationaftersuccessfulleftatrialappendageocclusionassessmentwithcardiaccomputedtomography AT annikawenke impactofleftatrialappendagemorphologyonthrombusformationaftersuccessfulleftatrialappendageocclusionassessmentwithcardiaccomputedtomography AT isharsinggill impactofleftatrialappendagemorphologyonthrombusformationaftersuccessfulleftatrialappendageocclusionassessmentwithcardiaccomputedtomography AT ibrahimelbattrawy impactofleftatrialappendagemorphologyonthrombusformationaftersuccessfulleftatrialappendageocclusionassessmentwithcardiaccomputedtomography AT jurgenkuschyk impactofleftatrialappendagemorphologyonthrombusformationaftersuccessfulleftatrialappendageocclusionassessmentwithcardiaccomputedtomography AT theanopapavassiliu impactofleftatrialappendagemorphologyonthrombusformationaftersuccessfulleftatrialappendageocclusionassessmentwithcardiaccomputedtomography AT ursulahoffmann impactofleftatrialappendagemorphologyonthrombusformationaftersuccessfulleftatrialappendageocclusionassessmentwithcardiaccomputedtomography AT kambismashayekhi impactofleftatrialappendagemorphologyonthrombusformationaftersuccessfulleftatrialappendageocclusionassessmentwithcardiaccomputedtomography AT stefanoschoenberg impactofleftatrialappendagemorphologyonthrombusformationaftersuccessfulleftatrialappendageocclusionassessmentwithcardiaccomputedtomography AT martinborggrefe impactofleftatrialappendagemorphologyonthrombusformationaftersuccessfulleftatrialappendageocclusionassessmentwithcardiaccomputedtomography AT thomashenzler impactofleftatrialappendagemorphologyonthrombusformationaftersuccessfulleftatrialappendageocclusionassessmentwithcardiaccomputedtomography AT ibrahimakin impactofleftatrialappendagemorphologyonthrombusformationaftersuccessfulleftatrialappendageocclusionassessmentwithcardiaccomputedtomography
_version_	1718388409860358144

Impact of left atrial appendage morphology on thrombus formation after successful left atrial appendage occlusion: Assessment with cardiac-computed-tomography

Ejemplares similares