Metabolic Reprogramming and Reconstruction: Integration of Experimental and Computational Studies to Set the Path Forward in ADPKD

Metabolic reprogramming is a key feature of Autosomal Dominant Polycystic Kidney Disease (ADPKD) characterized by changes in cellular pathways occurring in response to the pathological cell conditions. In ADPKD, a broad range of dysregulated pathways have been found. The studies supporting alteratio...

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Autores principales:	Roberto Pagliarini, Christine Podrini
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	metabolism systems biology systems medicine therapeutics drug repositioning ADPKD Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ae76745dd9a24741b189a4bd188d2ce9
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spelling	oai:doaj.org-article:ae76745dd9a24741b189a4bd188d2ce92021-11-30T17:56:24ZMetabolic Reprogramming and Reconstruction: Integration of Experimental and Computational Studies to Set the Path Forward in ADPKD2296-858X10.3389/fmed.2021.740087https://doaj.org/article/ae76745dd9a24741b189a4bd188d2ce92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.740087/fullhttps://doaj.org/toc/2296-858XMetabolic reprogramming is a key feature of Autosomal Dominant Polycystic Kidney Disease (ADPKD) characterized by changes in cellular pathways occurring in response to the pathological cell conditions. In ADPKD, a broad range of dysregulated pathways have been found. The studies supporting alterations in cell metabolism have shown that the metabolic preference for abnormal cystic growth is to utilize aerobic glycolysis, increasing glutamine uptake and reducing oxidative phosphorylation, consequently resulting in ADPKD cells shifting their energy to alternative energetic pathways. The mechanism behind the role of the polycystin proteins and how it leads to disease remains unclear, despite the identification of numerous signaling pathways. The integration of computational data analysis that accompanies experimental findings was pivotal in the identification of metabolic reprogramming in ADPKD. Here, we summarize the important results and argue that their exploitation may give further insights into the regulative mechanisms driving metabolic reprogramming in ADPKD. The aim of this review is to provide a comprehensive overview on metabolic focused studies and potential targets for treatment, and to propose that computational approaches could be instrumental in advancing this field of research.Roberto PagliariniChristine PodriniFrontiers Media S.A.articlemetabolismsystems biologysystems medicinetherapeuticsdrug repositioningADPKDMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	metabolism systems biology systems medicine therapeutics drug repositioning ADPKD Medicine (General) R5-920
spellingShingle	metabolism systems biology systems medicine therapeutics drug repositioning ADPKD Medicine (General) R5-920 Roberto Pagliarini Christine Podrini Metabolic Reprogramming and Reconstruction: Integration of Experimental and Computational Studies to Set the Path Forward in ADPKD
description	Metabolic reprogramming is a key feature of Autosomal Dominant Polycystic Kidney Disease (ADPKD) characterized by changes in cellular pathways occurring in response to the pathological cell conditions. In ADPKD, a broad range of dysregulated pathways have been found. The studies supporting alterations in cell metabolism have shown that the metabolic preference for abnormal cystic growth is to utilize aerobic glycolysis, increasing glutamine uptake and reducing oxidative phosphorylation, consequently resulting in ADPKD cells shifting their energy to alternative energetic pathways. The mechanism behind the role of the polycystin proteins and how it leads to disease remains unclear, despite the identification of numerous signaling pathways. The integration of computational data analysis that accompanies experimental findings was pivotal in the identification of metabolic reprogramming in ADPKD. Here, we summarize the important results and argue that their exploitation may give further insights into the regulative mechanisms driving metabolic reprogramming in ADPKD. The aim of this review is to provide a comprehensive overview on metabolic focused studies and potential targets for treatment, and to propose that computational approaches could be instrumental in advancing this field of research.
format	article
author	Roberto Pagliarini Christine Podrini
author_facet	Roberto Pagliarini Christine Podrini
author_sort	Roberto Pagliarini
title	Metabolic Reprogramming and Reconstruction: Integration of Experimental and Computational Studies to Set the Path Forward in ADPKD
title_short	Metabolic Reprogramming and Reconstruction: Integration of Experimental and Computational Studies to Set the Path Forward in ADPKD
title_full	Metabolic Reprogramming and Reconstruction: Integration of Experimental and Computational Studies to Set the Path Forward in ADPKD
title_fullStr	Metabolic Reprogramming and Reconstruction: Integration of Experimental and Computational Studies to Set the Path Forward in ADPKD
title_full_unstemmed	Metabolic Reprogramming and Reconstruction: Integration of Experimental and Computational Studies to Set the Path Forward in ADPKD
title_sort	metabolic reprogramming and reconstruction: integration of experimental and computational studies to set the path forward in adpkd
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ae76745dd9a24741b189a4bd188d2ce9
work_keys_str_mv	AT robertopagliarini metabolicreprogrammingandreconstructionintegrationofexperimentalandcomputationalstudiestosetthepathforwardinadpkd AT christinepodrini metabolicreprogrammingandreconstructionintegrationofexperimentalandcomputationalstudiestosetthepathforwardinadpkd
_version_	1718406402002649088

Metabolic Reprogramming and Reconstruction: Integration of Experimental and Computational Studies to Set the Path Forward in ADPKD

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