Zebrafish as a model to study inflammation: A tool for drug discovery
This study aims to demonstrate the applicability and importance of zebrafish (Danio rerio) model to study acute and chronic inflammatory responses induced by different stimuli: carrageenan phlogogen (nonimmune); acute infection by bacteria (immune); foreign body reaction (chronic inflammation by rou...
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Elsevier
2021
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oai:doaj.org-article:ae76d419f0494d8c82c765a21497bef12021-11-14T04:29:29ZZebrafish as a model to study inflammation: A tool for drug discovery0753-332210.1016/j.biopha.2021.112310https://doaj.org/article/ae76d419f0494d8c82c765a21497bef12021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221010945https://doaj.org/toc/0753-3322This study aims to demonstrate the applicability and importance of zebrafish (Danio rerio) model to study acute and chronic inflammatory responses induced by different stimuli: carrageenan phlogogen (nonimmune); acute infection by bacteria (immune); foreign body reaction (chronic inflammation by round glass coverslip implantation); reaction induced by xenotransplantation. In addition to the advantages of presenting low breeding cost, high prolificity, transparent embryos, high number of individuals belonging to the same spawning and high genetic similarity that favor translational responses to vertebrate organisms like humans, zebrafish proved to be an excellent tool, allowing the evaluation of edema formation, accumulation of inflammatory cells in the exudate, mediators, signaling pathways, gene expression and production of specific proteins. Our studies demonstrated the versatility of fish models to investigate the inflammatory response and its pathophysiology, essential for the successful development of studies to discover innovative pharmacological strategies.Marco A.A. BeloMelque F. OliveiraSusana L. OliveiraMayumi F. AracatiLetícia F. RodriguesCamila C. CostaGabriel CondeJuliana M.M. GomesMariana N.L. PrataAyslan BarraThalita M. ValverdeDaniela C. de MeloSilas F. EtoDayanne C. FernandesMarina G.M.C. RomeroJosé D. Corrêa JúniorJuliana O. SilvaAndre L.B. BarrosAndrea C. PerezIves Charlie-SilvaElsevierarticleInflammatory reactionTeleost fishInnate ImmunityAcute and chronic inflammationForeign body reactionXenotransplantationTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112310- (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Inflammatory reaction Teleost fish Innate Immunity Acute and chronic inflammation Foreign body reaction Xenotransplantation Therapeutics. Pharmacology RM1-950 |
| spellingShingle |
Inflammatory reaction Teleost fish Innate Immunity Acute and chronic inflammation Foreign body reaction Xenotransplantation Therapeutics. Pharmacology RM1-950 Marco A.A. Belo Melque F. Oliveira Susana L. Oliveira Mayumi F. Aracati Letícia F. Rodrigues Camila C. Costa Gabriel Conde Juliana M.M. Gomes Mariana N.L. Prata Ayslan Barra Thalita M. Valverde Daniela C. de Melo Silas F. Eto Dayanne C. Fernandes Marina G.M.C. Romero José D. Corrêa Júnior Juliana O. Silva Andre L.B. Barros Andrea C. Perez Ives Charlie-Silva Zebrafish as a model to study inflammation: A tool for drug discovery |
| description |
This study aims to demonstrate the applicability and importance of zebrafish (Danio rerio) model to study acute and chronic inflammatory responses induced by different stimuli: carrageenan phlogogen (nonimmune); acute infection by bacteria (immune); foreign body reaction (chronic inflammation by round glass coverslip implantation); reaction induced by xenotransplantation. In addition to the advantages of presenting low breeding cost, high prolificity, transparent embryos, high number of individuals belonging to the same spawning and high genetic similarity that favor translational responses to vertebrate organisms like humans, zebrafish proved to be an excellent tool, allowing the evaluation of edema formation, accumulation of inflammatory cells in the exudate, mediators, signaling pathways, gene expression and production of specific proteins. Our studies demonstrated the versatility of fish models to investigate the inflammatory response and its pathophysiology, essential for the successful development of studies to discover innovative pharmacological strategies. |
| format |
article |
| author |
Marco A.A. Belo Melque F. Oliveira Susana L. Oliveira Mayumi F. Aracati Letícia F. Rodrigues Camila C. Costa Gabriel Conde Juliana M.M. Gomes Mariana N.L. Prata Ayslan Barra Thalita M. Valverde Daniela C. de Melo Silas F. Eto Dayanne C. Fernandes Marina G.M.C. Romero José D. Corrêa Júnior Juliana O. Silva Andre L.B. Barros Andrea C. Perez Ives Charlie-Silva |
| author_facet |
Marco A.A. Belo Melque F. Oliveira Susana L. Oliveira Mayumi F. Aracati Letícia F. Rodrigues Camila C. Costa Gabriel Conde Juliana M.M. Gomes Mariana N.L. Prata Ayslan Barra Thalita M. Valverde Daniela C. de Melo Silas F. Eto Dayanne C. Fernandes Marina G.M.C. Romero José D. Corrêa Júnior Juliana O. Silva Andre L.B. Barros Andrea C. Perez Ives Charlie-Silva |
| author_sort |
Marco A.A. Belo |
| title |
Zebrafish as a model to study inflammation: A tool for drug discovery |
| title_short |
Zebrafish as a model to study inflammation: A tool for drug discovery |
| title_full |
Zebrafish as a model to study inflammation: A tool for drug discovery |
| title_fullStr |
Zebrafish as a model to study inflammation: A tool for drug discovery |
| title_full_unstemmed |
Zebrafish as a model to study inflammation: A tool for drug discovery |
| title_sort |
zebrafish as a model to study inflammation: a tool for drug discovery |
| publisher |
Elsevier |
| publishDate |
2021 |
| url |
https://doaj.org/article/ae76d419f0494d8c82c765a21497bef1 |
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