The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level

The integrity of the stratified epithelia relies on controlled cell turnover but it is unclear how mRNA binding proteins regulates this. Here, the authors show that the RNA binding protein Y-box binding protein-1 translationally represses cytokines, so preventing senescence and maintaining epidermal...

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Autores principales:	Eunjeong Kwon, Kristina Todorova, Jun Wang, Rastislav Horos, Kevin K. Lee, Victor A. Neel, Gian Luca Negri, Poul H. Sorensen, Sam W. Lee, Matthias W. Hentze, Anna Mandinova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ae77c37590464e83bc58037121dc3a32
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spelling	oai:doaj.org-article:ae77c37590464e83bc58037121dc3a322021-12-02T14:40:55ZThe RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level10.1038/s41467-018-04092-02041-1723https://doaj.org/article/ae77c37590464e83bc58037121dc3a322018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04092-0https://doaj.org/toc/2041-1723The integrity of the stratified epithelia relies on controlled cell turnover but it is unclear how mRNA binding proteins regulates this. Here, the authors show that the RNA binding protein Y-box binding protein-1 translationally represses cytokines, so preventing senescence and maintaining epidermal homeostasis.Eunjeong KwonKristina TodorovaJun WangRastislav HorosKevin K. LeeVictor A. NeelGian Luca NegriPoul H. SorensenSam W. LeeMatthias W. HentzeAnna MandinovaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eunjeong Kwon Kristina Todorova Jun Wang Rastislav Horos Kevin K. Lee Victor A. Neel Gian Luca Negri Poul H. Sorensen Sam W. Lee Matthias W. Hentze Anna Mandinova The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level
description	The integrity of the stratified epithelia relies on controlled cell turnover but it is unclear how mRNA binding proteins regulates this. Here, the authors show that the RNA binding protein Y-box binding protein-1 translationally represses cytokines, so preventing senescence and maintaining epidermal homeostasis.
format	article
author	Eunjeong Kwon Kristina Todorova Jun Wang Rastislav Horos Kevin K. Lee Victor A. Neel Gian Luca Negri Poul H. Sorensen Sam W. Lee Matthias W. Hentze Anna Mandinova
author_facet	Eunjeong Kwon Kristina Todorova Jun Wang Rastislav Horos Kevin K. Lee Victor A. Neel Gian Luca Negri Poul H. Sorensen Sam W. Lee Matthias W. Hentze Anna Mandinova
author_sort	Eunjeong Kwon
title	The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level
title_short	The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level
title_full	The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level
title_fullStr	The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level
title_full_unstemmed	The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level
title_sort	rna-binding protein ybx1 regulates epidermal progenitors at a posttranscriptional level
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ae77c37590464e83bc58037121dc3a32
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The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level

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