Bioactive Flavonoids Icaritin and Icariin Protect against Cerebral Ischemia–Reperfusion-Associated Apoptosis and Extracellular Matrix Accumulation in an Ischemic Stroke Mouse Model

Stroke, which is the second leading cause of mortality in the world, is urgently needed to explore the medical strategies for ischemic stroke treatment. Both icariin (ICA) and icaritin (ICT) are the major active flavonoids extracted from <i>Herba epimedii</i> that have been regarded as t...

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Autores principales:	Cheng-Tien Wu, Man-Chih Chen, Shing-Hwa Liu, Ting-Hua Yang, Lin-Hwa Long, Siao-Syun Guan, Chang-Mu Chen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	extracellular matrix icariin icaritin ischemic stroke middle cerebral artery occlusion Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ae79232e369c43e3958a3cf5bb559d8f
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spelling	oai:doaj.org-article:ae79232e369c43e3958a3cf5bb559d8f2021-11-25T16:51:17ZBioactive Flavonoids Icaritin and Icariin Protect against Cerebral Ischemia–Reperfusion-Associated Apoptosis and Extracellular Matrix Accumulation in an Ischemic Stroke Mouse Model10.3390/biomedicines91117192227-9059https://doaj.org/article/ae79232e369c43e3958a3cf5bb559d8f2021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1719https://doaj.org/toc/2227-9059Stroke, which is the second leading cause of mortality in the world, is urgently needed to explore the medical strategies for ischemic stroke treatment. Both icariin (ICA) and icaritin (ICT) are the major active flavonoids extracted from <i>Herba epimedii</i> that have been regarded as the neuroprotective agents in disease models. In this study, we aimed to investigate and compare the neuroprotective effects of ICA and ICT in a middle cerebral artery occlusion (MCAO) mouse model. Male ICR mice were pretreated with both ICA and ICT, which ameliorated body weight loss, neurological injury, infarct volume, and pathological change in acute ischemic stroke mice. Furthermore, administration of both ICA and ICT could also protect against neuronal cell apoptotic death, oxidative and nitrosative stress, lipid peroxidation, and extracellular matrix (ECM) accumulation in the brains. The neuroprotective effects of ICT are slightly better than that of ICA in acute cerebral ischemic stroke mice. These results suggest that pretreatment with both ICA and ICT improves the neuronal cell apoptosis and responses of oxidative/nitrosative stress and counteracts the ECM accumulation in the brains of acute cerebral ischemic stroke mice. Both ICA and ICT treatment may serve as a useful therapeutic strategy for acute ischemic stroke.Cheng-Tien WuMan-Chih ChenShing-Hwa LiuTing-Hua YangLin-Hwa LongSiao-Syun GuanChang-Mu ChenMDPI AGarticleextracellular matrixicariinicaritinischemic strokemiddle cerebral artery occlusionBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1719, p 1719 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	extracellular matrix icariin icaritin ischemic stroke middle cerebral artery occlusion Biology (General) QH301-705.5
spellingShingle	extracellular matrix icariin icaritin ischemic stroke middle cerebral artery occlusion Biology (General) QH301-705.5 Cheng-Tien Wu Man-Chih Chen Shing-Hwa Liu Ting-Hua Yang Lin-Hwa Long Siao-Syun Guan Chang-Mu Chen Bioactive Flavonoids Icaritin and Icariin Protect against Cerebral Ischemia–Reperfusion-Associated Apoptosis and Extracellular Matrix Accumulation in an Ischemic Stroke Mouse Model
description	Stroke, which is the second leading cause of mortality in the world, is urgently needed to explore the medical strategies for ischemic stroke treatment. Both icariin (ICA) and icaritin (ICT) are the major active flavonoids extracted from <i>Herba epimedii</i> that have been regarded as the neuroprotective agents in disease models. In this study, we aimed to investigate and compare the neuroprotective effects of ICA and ICT in a middle cerebral artery occlusion (MCAO) mouse model. Male ICR mice were pretreated with both ICA and ICT, which ameliorated body weight loss, neurological injury, infarct volume, and pathological change in acute ischemic stroke mice. Furthermore, administration of both ICA and ICT could also protect against neuronal cell apoptotic death, oxidative and nitrosative stress, lipid peroxidation, and extracellular matrix (ECM) accumulation in the brains. The neuroprotective effects of ICT are slightly better than that of ICA in acute cerebral ischemic stroke mice. These results suggest that pretreatment with both ICA and ICT improves the neuronal cell apoptosis and responses of oxidative/nitrosative stress and counteracts the ECM accumulation in the brains of acute cerebral ischemic stroke mice. Both ICA and ICT treatment may serve as a useful therapeutic strategy for acute ischemic stroke.
format	article
author	Cheng-Tien Wu Man-Chih Chen Shing-Hwa Liu Ting-Hua Yang Lin-Hwa Long Siao-Syun Guan Chang-Mu Chen
author_facet	Cheng-Tien Wu Man-Chih Chen Shing-Hwa Liu Ting-Hua Yang Lin-Hwa Long Siao-Syun Guan Chang-Mu Chen
author_sort	Cheng-Tien Wu
title	Bioactive Flavonoids Icaritin and Icariin Protect against Cerebral Ischemia–Reperfusion-Associated Apoptosis and Extracellular Matrix Accumulation in an Ischemic Stroke Mouse Model
title_short	Bioactive Flavonoids Icaritin and Icariin Protect against Cerebral Ischemia–Reperfusion-Associated Apoptosis and Extracellular Matrix Accumulation in an Ischemic Stroke Mouse Model
title_full	Bioactive Flavonoids Icaritin and Icariin Protect against Cerebral Ischemia–Reperfusion-Associated Apoptosis and Extracellular Matrix Accumulation in an Ischemic Stroke Mouse Model
title_fullStr	Bioactive Flavonoids Icaritin and Icariin Protect against Cerebral Ischemia–Reperfusion-Associated Apoptosis and Extracellular Matrix Accumulation in an Ischemic Stroke Mouse Model
title_full_unstemmed	Bioactive Flavonoids Icaritin and Icariin Protect against Cerebral Ischemia–Reperfusion-Associated Apoptosis and Extracellular Matrix Accumulation in an Ischemic Stroke Mouse Model
title_sort	bioactive flavonoids icaritin and icariin protect against cerebral ischemia–reperfusion-associated apoptosis and extracellular matrix accumulation in an ischemic stroke mouse model
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ae79232e369c43e3958a3cf5bb559d8f
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Bioactive Flavonoids Icaritin and Icariin Protect against Cerebral Ischemia–Reperfusion-Associated Apoptosis and Extracellular Matrix Accumulation in an Ischemic Stroke Mouse Model

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