High-dose maternal folic acid supplementation before conception impairs reversal learning in offspring mice

Abstract Maternal folic acid (FA) supplementation prior to and during gestation is recommended for the prevention of neural tube closure defects in the developing embryo. Prior studies, however, suggested that excessive FA supplementation during gestation can be associated with toxic effects on the...

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Auteurs principaux:	Kristin S. Henzel, Devon P. Ryan, Susanne Schröder, Marco Weiergräber, Dan Ehninger
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Medicine R Science Q
Accès en ligne:	https://doaj.org/article/ae84557aeaeb458e8f1dee7f29446322
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spelling	oai:doaj.org-article:ae84557aeaeb458e8f1dee7f294463222021-12-02T11:40:50ZHigh-dose maternal folic acid supplementation before conception impairs reversal learning in offspring mice10.1038/s41598-017-03158-12045-2322https://doaj.org/article/ae84557aeaeb458e8f1dee7f294463222017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03158-1https://doaj.org/toc/2045-2322Abstract Maternal folic acid (FA) supplementation prior to and during gestation is recommended for the prevention of neural tube closure defects in the developing embryo. Prior studies, however, suggested that excessive FA supplementation during gestation can be associated with toxic effects on the developing organism. Here, we address whether maternal dietary folic acid supplementation at 40 mg/kg chow (FD), restricted to a period prior to conception, affects neurobehavioural development in the offspring generation. Detailed behavioural analyses showed reversal learning impairments in the Morris water maze in offspring derived from dams exposed to FD prior to conceiving. Furthermore, offspring of FD dams showed minor and transient gene expression differences relative to controls. Our data suggest that temporary exposure of female germ cells to FD is sufficient to cause impaired cognitive flexibility in the subsequent generation.Kristin S. HenzelDevon P. RyanSusanne SchröderMarco WeiergräberDan EhningerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kristin S. Henzel Devon P. Ryan Susanne Schröder Marco Weiergräber Dan Ehninger High-dose maternal folic acid supplementation before conception impairs reversal learning in offspring mice
description	Abstract Maternal folic acid (FA) supplementation prior to and during gestation is recommended for the prevention of neural tube closure defects in the developing embryo. Prior studies, however, suggested that excessive FA supplementation during gestation can be associated with toxic effects on the developing organism. Here, we address whether maternal dietary folic acid supplementation at 40 mg/kg chow (FD), restricted to a period prior to conception, affects neurobehavioural development in the offspring generation. Detailed behavioural analyses showed reversal learning impairments in the Morris water maze in offspring derived from dams exposed to FD prior to conceiving. Furthermore, offspring of FD dams showed minor and transient gene expression differences relative to controls. Our data suggest that temporary exposure of female germ cells to FD is sufficient to cause impaired cognitive flexibility in the subsequent generation.
format	article
author	Kristin S. Henzel Devon P. Ryan Susanne Schröder Marco Weiergräber Dan Ehninger
author_facet	Kristin S. Henzel Devon P. Ryan Susanne Schröder Marco Weiergräber Dan Ehninger
author_sort	Kristin S. Henzel
title	High-dose maternal folic acid supplementation before conception impairs reversal learning in offspring mice
title_short	High-dose maternal folic acid supplementation before conception impairs reversal learning in offspring mice
title_full	High-dose maternal folic acid supplementation before conception impairs reversal learning in offspring mice
title_fullStr	High-dose maternal folic acid supplementation before conception impairs reversal learning in offspring mice
title_full_unstemmed	High-dose maternal folic acid supplementation before conception impairs reversal learning in offspring mice
title_sort	high-dose maternal folic acid supplementation before conception impairs reversal learning in offspring mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ae84557aeaeb458e8f1dee7f29446322
work_keys_str_mv	AT kristinshenzel highdosematernalfolicacidsupplementationbeforeconceptionimpairsreversallearninginoffspringmice AT devonpryan highdosematernalfolicacidsupplementationbeforeconceptionimpairsreversallearninginoffspringmice AT susanneschroder highdosematernalfolicacidsupplementationbeforeconceptionimpairsreversallearninginoffspringmice AT marcoweiergraber highdosematernalfolicacidsupplementationbeforeconceptionimpairsreversallearninginoffspringmice AT danehninger highdosematernalfolicacidsupplementationbeforeconceptionimpairsreversallearninginoffspringmice
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High-dose maternal folic acid supplementation before conception impairs reversal learning in offspring mice

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