NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance

Robo3 is a divergent, multifunctional member of the Robo receptor family that mediates axon guidance by its ligand NELL2 instead of the canonical Slit ligands. Here, the authors present the crystal structures of human Robo3 in complex with NELL1 and NELL2, and they show through biophysical and funct...

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Autores principales:	Joseph S. Pak, Zachary J. DeLoughery, Jing Wang, Nischal Acharya, Yeonwoo Park, Alexander Jaworski, Engin Özkan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ae851800121c457195d702cb407babf9
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spelling	oai:doaj.org-article:ae851800121c457195d702cb407babf92021-12-02T16:49:47ZNELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance10.1038/s41467-020-15211-12041-1723https://doaj.org/article/ae851800121c457195d702cb407babf92020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15211-1https://doaj.org/toc/2041-1723Robo3 is a divergent, multifunctional member of the Robo receptor family that mediates axon guidance by its ligand NELL2 instead of the canonical Slit ligands. Here, the authors present the crystal structures of human Robo3 in complex with NELL1 and NELL2, and they show through biophysical and functional assays how NELL-Robo3 affinity and ligand-induced receptor multimerization control axon guidance activity.Joseph S. PakZachary J. DeLougheryJing WangNischal AcharyaYeonwoo ParkAlexander JaworskiEngin ÖzkanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joseph S. Pak Zachary J. DeLoughery Jing Wang Nischal Acharya Yeonwoo Park Alexander Jaworski Engin Özkan NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance
description	Robo3 is a divergent, multifunctional member of the Robo receptor family that mediates axon guidance by its ligand NELL2 instead of the canonical Slit ligands. Here, the authors present the crystal structures of human Robo3 in complex with NELL1 and NELL2, and they show through biophysical and functional assays how NELL-Robo3 affinity and ligand-induced receptor multimerization control axon guidance activity.
format	article
author	Joseph S. Pak Zachary J. DeLoughery Jing Wang Nischal Acharya Yeonwoo Park Alexander Jaworski Engin Özkan
author_facet	Joseph S. Pak Zachary J. DeLoughery Jing Wang Nischal Acharya Yeonwoo Park Alexander Jaworski Engin Özkan
author_sort	Joseph S. Pak
title	NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance
title_short	NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance
title_full	NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance
title_fullStr	NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance
title_full_unstemmed	NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance
title_sort	nell2-robo3 complex structure reveals mechanisms of receptor activation for axon guidance
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ae851800121c457195d702cb407babf9
work_keys_str_mv	AT josephspak nell2robo3complexstructurerevealsmechanismsofreceptoractivationforaxonguidance AT zacharyjdeloughery nell2robo3complexstructurerevealsmechanismsofreceptoractivationforaxonguidance AT jingwang nell2robo3complexstructurerevealsmechanismsofreceptoractivationforaxonguidance AT nischalacharya nell2robo3complexstructurerevealsmechanismsofreceptoractivationforaxonguidance AT yeonwoopark nell2robo3complexstructurerevealsmechanismsofreceptoractivationforaxonguidance AT alexanderjaworski nell2robo3complexstructurerevealsmechanismsofreceptoractivationforaxonguidance AT enginozkan nell2robo3complexstructurerevealsmechanismsofreceptoractivationforaxonguidance
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NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance

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