Correlation between vascular endothelial growth factor and nonperfused areas in macular edema secondary to branch retinal vein occlusion

Masato Fujikawa, Osamu Sawada, Taichiro Miyake, Masashi Kakinoki, Tomoko Sawada, Hajime Kawamura, Masahito Ohji Department of Ophthalmology, Shiga University of Medical Science, Otsu, Japan Purpose: To determine the role of vascular endothelial growth factor (VEGF) in macular edema secondary to bran...

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Autores principales:	Fujikawa M, Sawada O, Miyake T, Kakinoki M, Sawada T, Kawamura H, Ohji M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/ae857be3785e4b86ba4103b803f80fcf
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spelling	oai:doaj.org-article:ae857be3785e4b86ba4103b803f80fcf2021-12-02T00:15:25ZCorrelation between vascular endothelial growth factor and nonperfused areas in macular edema secondary to branch retinal vein occlusion1177-54671177-5483https://doaj.org/article/ae857be3785e4b86ba4103b803f80fcf2013-07-01T00:00:00Zhttp://www.dovepress.com/correlation-between-vascular-endothelial-growth-factor-and-nonperfused-a13704https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Masato Fujikawa, Osamu Sawada, Taichiro Miyake, Masashi Kakinoki, Tomoko Sawada, Hajime Kawamura, Masahito Ohji Department of Ophthalmology, Shiga University of Medical Science, Otsu, Japan Purpose: To determine the role of vascular endothelial growth factor (VEGF) in macular edema secondary to branch retinal vein occlusion (BRVO). Patients and methods: Aqueous humor samples were collected from 52 eyes with macular edema secondary to BRVO before intravitreal drug injections and from 62 control eyes with cataract. VEGF was measured using an enzyme-linked immunosorbent assay. Fluorescein angiography showed capillary nonperfused areas (NPAs). Macular edema was evaluated by optical coherence tomography as the central retinal thickness. Results: The mean aqueous VEGF levels in eyes with BRVO and control eyes with cataract were, respectively, 290.5 pg/mL ± 294.9 pg/mL (range 81.9 pg/mL-1567.3 pg/mL) and 118.0 pg/mL ± 50.1 pg/mL (range 24.6 pg/mL-241.1 pg/mL), which differed significantly (P < 0.0001). The mean VEGF level in eyes with BRVO without apparent NPA was 171.4 pg/mL ± 52.5 pg/mL (range 90.9 pg/mL-299.9 pg/mL), which was significantly higher than controls (P = 0.001). VEGF levels were correlated positively with the size of NPA (P = 0.0002) but not with the central retinal thickness. Conclusion: The aqueous VEGF concentration in patients with macular edema secondary to BRVO increased significantly and was correlated significantly with the size of NPA. Aqueous VEGF increased even in eyes without apparent NPA. Keywords: aqueous humor, branch retinal vein occlusion, macular edemaFujikawa MSawada OMiyake TKakinoki MSawada TKawamura HOhji MDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 1497-1501 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Fujikawa M Sawada O Miyake T Kakinoki M Sawada T Kawamura H Ohji M Correlation between vascular endothelial growth factor and nonperfused areas in macular edema secondary to branch retinal vein occlusion
description	Masato Fujikawa, Osamu Sawada, Taichiro Miyake, Masashi Kakinoki, Tomoko Sawada, Hajime Kawamura, Masahito Ohji Department of Ophthalmology, Shiga University of Medical Science, Otsu, Japan Purpose: To determine the role of vascular endothelial growth factor (VEGF) in macular edema secondary to branch retinal vein occlusion (BRVO). Patients and methods: Aqueous humor samples were collected from 52 eyes with macular edema secondary to BRVO before intravitreal drug injections and from 62 control eyes with cataract. VEGF was measured using an enzyme-linked immunosorbent assay. Fluorescein angiography showed capillary nonperfused areas (NPAs). Macular edema was evaluated by optical coherence tomography as the central retinal thickness. Results: The mean aqueous VEGF levels in eyes with BRVO and control eyes with cataract were, respectively, 290.5 pg/mL ± 294.9 pg/mL (range 81.9 pg/mL-1567.3 pg/mL) and 118.0 pg/mL ± 50.1 pg/mL (range 24.6 pg/mL-241.1 pg/mL), which differed significantly (P < 0.0001). The mean VEGF level in eyes with BRVO without apparent NPA was 171.4 pg/mL ± 52.5 pg/mL (range 90.9 pg/mL-299.9 pg/mL), which was significantly higher than controls (P = 0.001). VEGF levels were correlated positively with the size of NPA (P = 0.0002) but not with the central retinal thickness. Conclusion: The aqueous VEGF concentration in patients with macular edema secondary to BRVO increased significantly and was correlated significantly with the size of NPA. Aqueous VEGF increased even in eyes without apparent NPA. Keywords: aqueous humor, branch retinal vein occlusion, macular edema
format	article
author	Fujikawa M Sawada O Miyake T Kakinoki M Sawada T Kawamura H Ohji M
author_facet	Fujikawa M Sawada O Miyake T Kakinoki M Sawada T Kawamura H Ohji M
author_sort	Fujikawa M
title	Correlation between vascular endothelial growth factor and nonperfused areas in macular edema secondary to branch retinal vein occlusion
title_short	Correlation between vascular endothelial growth factor and nonperfused areas in macular edema secondary to branch retinal vein occlusion
title_full	Correlation between vascular endothelial growth factor and nonperfused areas in macular edema secondary to branch retinal vein occlusion
title_fullStr	Correlation between vascular endothelial growth factor and nonperfused areas in macular edema secondary to branch retinal vein occlusion
title_full_unstemmed	Correlation between vascular endothelial growth factor and nonperfused areas in macular edema secondary to branch retinal vein occlusion
title_sort	correlation between vascular endothelial growth factor and nonperfused areas in macular edema secondary to branch retinal vein occlusion
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/ae857be3785e4b86ba4103b803f80fcf
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Correlation between vascular endothelial growth factor and nonperfused areas in macular edema secondary to branch retinal vein occlusion

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