Apathy and intrinsic functional connectivity networks in amnestic mild cognitive impairment

Soo Hyun Joo,1 Chang Uk Lee,1 Hyun Kook Lim2 1Department of Psychiatry, Seoul St Mary’s Hospital, Seoul, 2Department of Psychiatry, Saint Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea Background: Although several prior works reported th...

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Autores principales:	Joo SH, Lee CU, Lim HK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Apathy Amnestic Mild Cognitive Impairment Intrinsic Connectivity Networks Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/ae874617b8184f2e811566ca940130d2
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spelling	oai:doaj.org-article:ae874617b8184f2e811566ca940130d22021-12-02T07:16:59ZApathy and intrinsic functional connectivity networks in amnestic mild cognitive impairment1178-2021https://doaj.org/article/ae874617b8184f2e811566ca940130d22016-12-01T00:00:00Zhttps://www.dovepress.com/apathy-and-intrinsic-functional-connectivity-networks-in-amnestic-mild-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Soo Hyun Joo,1 Chang Uk Lee,1 Hyun Kook Lim2 1Department of Psychiatry, Seoul St Mary’s Hospital, Seoul, 2Department of Psychiatry, Saint Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea Background: Although several prior works reported that apathy is associated with conversion to Alzheimer’s disease in individuals with amnestic mild cognitive impairment (aMCI), effects of apathy on the functional connectivity (FC) of the brain remain unclear. In this study, we assessed the pattern of association between apathy and default mode network (DMN), salience network and central executive network (CEN) in aMCI subjects.Methods: Fifty subjects with aMCI and 50 controls (CONs) participated in this study. They underwent clinical assessments and magnetic resonance imaging for the structural and resting-state scan. We explored the patterns of association between apathy inventory (IA) total score and the whole-brain voxel-wise FCs of the DMN, salience network and CEN in aMCI subjects.Results: We observed that the FCs of the DMN were less and those of CEN were more in the aMCI group than the CON group. Total IA score was negatively correlated with FCs of the anterior cingulate within the DMN, and positively correlated with FCs of the middle frontal, inferior frontal, and supramarginal gyrus within the CEN in the aMCI group.Conclusion: Our findings suggest that distinctive patterns of association between apathy and FCs in the DMN and CEN in the aMCI group might reflect the putative role of functional network change in the development of apathy in aMCI. Keywords: apathy, amnestic mild cognitive impairment, intrinsic connectivity networksJoo SHLee CULim HKDove Medical PressarticleApathyAmnestic Mild Cognitive ImpairmentIntrinsic Connectivity NetworksNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 61-67 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Apathy Amnestic Mild Cognitive Impairment Intrinsic Connectivity Networks Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Apathy Amnestic Mild Cognitive Impairment Intrinsic Connectivity Networks Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Joo SH Lee CU Lim HK Apathy and intrinsic functional connectivity networks in amnestic mild cognitive impairment
description	Soo Hyun Joo,1 Chang Uk Lee,1 Hyun Kook Lim2 1Department of Psychiatry, Seoul St Mary’s Hospital, Seoul, 2Department of Psychiatry, Saint Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea Background: Although several prior works reported that apathy is associated with conversion to Alzheimer’s disease in individuals with amnestic mild cognitive impairment (aMCI), effects of apathy on the functional connectivity (FC) of the brain remain unclear. In this study, we assessed the pattern of association between apathy and default mode network (DMN), salience network and central executive network (CEN) in aMCI subjects.Methods: Fifty subjects with aMCI and 50 controls (CONs) participated in this study. They underwent clinical assessments and magnetic resonance imaging for the structural and resting-state scan. We explored the patterns of association between apathy inventory (IA) total score and the whole-brain voxel-wise FCs of the DMN, salience network and CEN in aMCI subjects.Results: We observed that the FCs of the DMN were less and those of CEN were more in the aMCI group than the CON group. Total IA score was negatively correlated with FCs of the anterior cingulate within the DMN, and positively correlated with FCs of the middle frontal, inferior frontal, and supramarginal gyrus within the CEN in the aMCI group.Conclusion: Our findings suggest that distinctive patterns of association between apathy and FCs in the DMN and CEN in the aMCI group might reflect the putative role of functional network change in the development of apathy in aMCI. Keywords: apathy, amnestic mild cognitive impairment, intrinsic connectivity networks
format	article
author	Joo SH Lee CU Lim HK
author_facet	Joo SH Lee CU Lim HK
author_sort	Joo SH
title	Apathy and intrinsic functional connectivity networks in amnestic mild cognitive impairment
title_short	Apathy and intrinsic functional connectivity networks in amnestic mild cognitive impairment
title_full	Apathy and intrinsic functional connectivity networks in amnestic mild cognitive impairment
title_fullStr	Apathy and intrinsic functional connectivity networks in amnestic mild cognitive impairment
title_full_unstemmed	Apathy and intrinsic functional connectivity networks in amnestic mild cognitive impairment
title_sort	apathy and intrinsic functional connectivity networks in amnestic mild cognitive impairment
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/ae874617b8184f2e811566ca940130d2
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_version_	1718399533440827392

Apathy and intrinsic functional connectivity networks in amnestic mild cognitive impairment

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