Metabolomics Insights into Inflammatory Bowel Disease: A Comprehensive Review

Inflammatory bowel disease (IBD) is a chronic, complex relapsing disorder characterised by immune dysregulation, gut microbiota alteration, and disturbed intestinal permeability. The diagnosis and the management of IBD are challenging due to the recurrent nature and complex evolution of the disease....

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Autores principales:	Laila Aldars-García, Javier P. Gisbert, María Chaparro
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	inflammatory bowel disease metabolomics microbiota Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/ae8a106f81ec45f7a3d42d695087862c
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spelling	oai:doaj.org-article:ae8a106f81ec45f7a3d42d695087862c2021-11-25T18:40:04ZMetabolomics Insights into Inflammatory Bowel Disease: A Comprehensive Review10.3390/ph141111901424-8247https://doaj.org/article/ae8a106f81ec45f7a3d42d695087862c2021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1190https://doaj.org/toc/1424-8247Inflammatory bowel disease (IBD) is a chronic, complex relapsing disorder characterised by immune dysregulation, gut microbiota alteration, and disturbed intestinal permeability. The diagnosis and the management of IBD are challenging due to the recurrent nature and complex evolution of the disease. Furthermore, the molecular mechanism underlying the aetiology and pathogenesis of IBD is still poorly understood. There is an unmet need for novel, reliable, and noninvasive tools for diagnosing and monitoring IBD. In addition, metabolomic profiles may provide a priori determination of optimal therapeutics and reveal novel targets for therapies. This review tries to gather scientific evidence to summarise the emerging contribution of metabolomics to elucidate the mechanisms underlying IBD and changes associated with disease phenotype and therapies, as well as to identify biomarkers with metabolic imbalance in those patients. Metabolite changes during health and disease could provide insights into the disease pathogenesis and the discovery of novel indicators for the diagnosis and prognosis assessment of IBD. Metabolomic studies in IBD have shown changes in tricarboxylic acid cycle intermediates, amino-acid and fatty-acid metabolism, and oxidative pathways. Metabolomics has made progress towards identifying metabolic alterations that may provide clinically useful biomarkers and a deeper understanding of the disease. However, at present, there is insufficient evidence evaluating the predictive accuracy of these molecular signatures and their diagnostic ability, which is necessary before metabolomic data can be translated into clinical practice.Laila Aldars-GarcíaJavier P. GisbertMaría ChaparroMDPI AGarticleinflammatory bowel diseasemetabolomicsmicrobiotaMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1190, p 1190 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	inflammatory bowel disease metabolomics microbiota Medicine R Pharmacy and materia medica RS1-441
spellingShingle	inflammatory bowel disease metabolomics microbiota Medicine R Pharmacy and materia medica RS1-441 Laila Aldars-García Javier P. Gisbert María Chaparro Metabolomics Insights into Inflammatory Bowel Disease: A Comprehensive Review
description	Inflammatory bowel disease (IBD) is a chronic, complex relapsing disorder characterised by immune dysregulation, gut microbiota alteration, and disturbed intestinal permeability. The diagnosis and the management of IBD are challenging due to the recurrent nature and complex evolution of the disease. Furthermore, the molecular mechanism underlying the aetiology and pathogenesis of IBD is still poorly understood. There is an unmet need for novel, reliable, and noninvasive tools for diagnosing and monitoring IBD. In addition, metabolomic profiles may provide a priori determination of optimal therapeutics and reveal novel targets for therapies. This review tries to gather scientific evidence to summarise the emerging contribution of metabolomics to elucidate the mechanisms underlying IBD and changes associated with disease phenotype and therapies, as well as to identify biomarkers with metabolic imbalance in those patients. Metabolite changes during health and disease could provide insights into the disease pathogenesis and the discovery of novel indicators for the diagnosis and prognosis assessment of IBD. Metabolomic studies in IBD have shown changes in tricarboxylic acid cycle intermediates, amino-acid and fatty-acid metabolism, and oxidative pathways. Metabolomics has made progress towards identifying metabolic alterations that may provide clinically useful biomarkers and a deeper understanding of the disease. However, at present, there is insufficient evidence evaluating the predictive accuracy of these molecular signatures and their diagnostic ability, which is necessary before metabolomic data can be translated into clinical practice.
format	article
author	Laila Aldars-García Javier P. Gisbert María Chaparro
author_facet	Laila Aldars-García Javier P. Gisbert María Chaparro
author_sort	Laila Aldars-García
title	Metabolomics Insights into Inflammatory Bowel Disease: A Comprehensive Review
title_short	Metabolomics Insights into Inflammatory Bowel Disease: A Comprehensive Review
title_full	Metabolomics Insights into Inflammatory Bowel Disease: A Comprehensive Review
title_fullStr	Metabolomics Insights into Inflammatory Bowel Disease: A Comprehensive Review
title_full_unstemmed	Metabolomics Insights into Inflammatory Bowel Disease: A Comprehensive Review
title_sort	metabolomics insights into inflammatory bowel disease: a comprehensive review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ae8a106f81ec45f7a3d42d695087862c
work_keys_str_mv	AT lailaaldarsgarcia metabolomicsinsightsintoinflammatoryboweldiseaseacomprehensivereview AT javierpgisbert metabolomicsinsightsintoinflammatoryboweldiseaseacomprehensivereview AT mariachaparro metabolomicsinsightsintoinflammatoryboweldiseaseacomprehensivereview
_version_	1718410857322381312

Metabolomics Insights into Inflammatory Bowel Disease: A Comprehensive Review

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