A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression

A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression

The stromal microenvironment plays a key role in the expansion of chronic lymphocytic leukemia. Here, the authors use the Eµ-TCL1 mouse model to show that leukemic B-cells induce the activation of retinoic acid synthesis in stromal cells of the lymphoid microenvironment, and that impacting on retino...

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Autores principales: Diego Farinello, Monika Wozińska, Elisa Lenti, Luca Genovese, Silvia Bianchessi, Edoardo Migliori, Nicolò Sacchetti, Alessia di Lillo, Maria Teresa Sabrina Bertilaccio, Claudia de Lalla, Roberta Valsecchi, Sabrina Bascones Gleave, David Lligé, Cristina Scielzo, Laura Mauri, Maria Grazia Ciampa, Lydia Scarfò, Rosa Bernardi, Dejan Lazarevic, Blanca Gonzalez-Farre, Lucia Bongiovanni, Elias Campo, Andrea Cerutti, Maurilio Ponzoni, Linda Pattini, Federico Caligaris-Cappio, Paolo Ghia, Andrea Brendolan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Q
Acceso en línea:https://doaj.org/article/ae8a25dfa5e64465b221fe7111cbb8b6
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spelling oai:doaj.org-article:ae8a25dfa5e64465b221fe7111cbb8b62021-12-02T16:49:31ZA retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression10.1038/s41467-018-04150-72041-1723https://doaj.org/article/ae8a25dfa5e64465b221fe7111cbb8b62018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04150-7https://doaj.org/toc/2041-1723The stromal microenvironment plays a key role in the expansion of chronic lymphocytic leukemia. Here, the authors use the Eµ-TCL1 mouse model to show that leukemic B-cells induce the activation of retinoic acid synthesis in stromal cells of the lymphoid microenvironment, and that impacting on retinoic acid signalling via diet or chemical inhibition prolonged survival by preventing leukemia dissemination and accumulation in lymphoid tissues.Diego FarinelloMonika WozińskaElisa LentiLuca GenoveseSilvia BianchessiEdoardo MiglioriNicolò SacchettiAlessia di LilloMaria Teresa Sabrina BertilaccioClaudia de LallaRoberta ValsecchiSabrina Bascones GleaveDavid LligéCristina ScielzoLaura MauriMaria Grazia CiampaLydia ScarfòRosa BernardiDejan LazarevicBlanca Gonzalez-FarreLucia BongiovanniElias CampoAndrea CeruttiMaurilio PonzoniLinda PattiniFederico Caligaris-CappioPaolo GhiaAndrea BrendolanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Diego Farinello
Monika Wozińska
Elisa Lenti
Luca Genovese
Silvia Bianchessi
Edoardo Migliori
Nicolò Sacchetti
Alessia di Lillo
Maria Teresa Sabrina Bertilaccio
Claudia de Lalla
Roberta Valsecchi
Sabrina Bascones Gleave
David Lligé
Cristina Scielzo
Laura Mauri
Maria Grazia Ciampa
Lydia Scarfò
Rosa Bernardi
Dejan Lazarevic
Blanca Gonzalez-Farre
Lucia Bongiovanni
Elias Campo
Andrea Cerutti
Maurilio Ponzoni
Linda Pattini
Federico Caligaris-Cappio
Paolo Ghia
Andrea Brendolan
A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression
description The stromal microenvironment plays a key role in the expansion of chronic lymphocytic leukemia. Here, the authors use the Eµ-TCL1 mouse model to show that leukemic B-cells induce the activation of retinoic acid synthesis in stromal cells of the lymphoid microenvironment, and that impacting on retinoic acid signalling via diet or chemical inhibition prolonged survival by preventing leukemia dissemination and accumulation in lymphoid tissues.
format article
author Diego Farinello
Monika Wozińska
Elisa Lenti
Luca Genovese
Silvia Bianchessi
Edoardo Migliori
Nicolò Sacchetti
Alessia di Lillo
Maria Teresa Sabrina Bertilaccio
Claudia de Lalla
Roberta Valsecchi
Sabrina Bascones Gleave
David Lligé
Cristina Scielzo
Laura Mauri
Maria Grazia Ciampa
Lydia Scarfò
Rosa Bernardi
Dejan Lazarevic
Blanca Gonzalez-Farre
Lucia Bongiovanni
Elias Campo
Andrea Cerutti
Maurilio Ponzoni
Linda Pattini
Federico Caligaris-Cappio
Paolo Ghia
Andrea Brendolan
author_facet Diego Farinello
Monika Wozińska
Elisa Lenti
Luca Genovese
Silvia Bianchessi
Edoardo Migliori
Nicolò Sacchetti
Alessia di Lillo
Maria Teresa Sabrina Bertilaccio
Claudia de Lalla
Roberta Valsecchi
Sabrina Bascones Gleave
David Lligé
Cristina Scielzo
Laura Mauri
Maria Grazia Ciampa
Lydia Scarfò
Rosa Bernardi
Dejan Lazarevic
Blanca Gonzalez-Farre
Lucia Bongiovanni
Elias Campo
Andrea Cerutti
Maurilio Ponzoni
Linda Pattini
Federico Caligaris-Cappio
Paolo Ghia
Andrea Brendolan
author_sort Diego Farinello
title A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression
title_short A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression
title_full A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression
title_fullStr A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression
title_full_unstemmed A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression
title_sort retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/ae8a25dfa5e64465b221fe7111cbb8b6
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