A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression

A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression

The stromal microenvironment plays a key role in the expansion of chronic lymphocytic leukemia. Here, the authors use the Eµ-TCL1 mouse model to show that leukemic B-cells induce the activation of retinoic acid synthesis in stromal cells of the lymphoid microenvironment, and that impacting on retino...

Full description

Saved in:
Bibliographic Details
Main Authors: Diego Farinello, Monika Wozińska, Elisa Lenti, Luca Genovese, Silvia Bianchessi, Edoardo Migliori, Nicolò Sacchetti, Alessia di Lillo, Maria Teresa Sabrina Bertilaccio, Claudia de Lalla, Roberta Valsecchi, Sabrina Bascones Gleave, David Lligé, Cristina Scielzo, Laura Mauri, Maria Grazia Ciampa, Lydia Scarfò, Rosa Bernardi, Dejan Lazarevic, Blanca Gonzalez-Farre, Lucia Bongiovanni, Elias Campo, Andrea Cerutti, Maurilio Ponzoni, Linda Pattini, Federico Caligaris-Cappio, Paolo Ghia, Andrea Brendolan
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
Q
Online Access:https://doaj.org/article/ae8a25dfa5e64465b221fe7111cbb8b6
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/ae8a25dfa5e64465b221fe7111cbb8b6

Similar Items