Reduced cardiac vagal modulation impacts on cognitive performance in chronic fatigue syndrome.

<h4>Background</h4>Cognitive difficulties and autonomic dysfunction have been reported separately in patients with chronic fatigue syndrome (CFS). A role for heart rate variability (HRV) in cognitive flexibility has been demonstrated in healthy individuals, but this relationship has not...

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Autores principales:	Alison Beaumont, Alexander R Burton, Jim Lemon, Barbara K Bennett, Andrew Lloyd, Uté Vollmer-Conna
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ae8e0bdfda4447be8da5115121f5748a
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spelling	oai:doaj.org-article:ae8e0bdfda4447be8da5115121f5748a2021-11-18T08:08:43ZReduced cardiac vagal modulation impacts on cognitive performance in chronic fatigue syndrome.1932-620310.1371/journal.pone.0049518https://doaj.org/article/ae8e0bdfda4447be8da5115121f5748a2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23166694/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Cognitive difficulties and autonomic dysfunction have been reported separately in patients with chronic fatigue syndrome (CFS). A role for heart rate variability (HRV) in cognitive flexibility has been demonstrated in healthy individuals, but this relationship has not as yet been examined in CFS. The objective of this study was to examine the relationship between HRV and cognitive performance in patients with CFS.<h4>Methods</h4>Participants were 30 patients with CFS and 40 healthy controls; the groups were matched for age, sex, education, body mass index, and hours of moderate exercise/week. Questionnaires were used to obtain relevant medical and demographic information, and assess current symptoms and functional impairment. Electrocardiograms, perceived fatigue/effort and performance data were recorded during cognitive tasks. Between-group differences in autonomic reactivity and associations with cognitive performance were analysed.<h4>Results</h4>Patients with CFS showed no deficits in performance accuracy, but were significantly slower than healthy controls. CFS was further characterized by low and unresponsive HRV; greater heart rate (HR) reactivity and prolonged HR-recovery after cognitive challenge. Fatigue levels, perceived effort and distress did not affect cognitive performance. HRV was consistently associated with performance indices and significantly predicted variance in cognitive outcomes.<h4>Conclusions</h4>These findings reveal for the first time an association between reduced cardiac vagal tone and cognitive impairment in CFS and confirm previous reports of diminished vagal activity.Alison BeaumontAlexander R BurtonJim LemonBarbara K BennettAndrew LloydUté Vollmer-ConnaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e49518 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alison Beaumont Alexander R Burton Jim Lemon Barbara K Bennett Andrew Lloyd Uté Vollmer-Conna Reduced cardiac vagal modulation impacts on cognitive performance in chronic fatigue syndrome.
description	<h4>Background</h4>Cognitive difficulties and autonomic dysfunction have been reported separately in patients with chronic fatigue syndrome (CFS). A role for heart rate variability (HRV) in cognitive flexibility has been demonstrated in healthy individuals, but this relationship has not as yet been examined in CFS. The objective of this study was to examine the relationship between HRV and cognitive performance in patients with CFS.<h4>Methods</h4>Participants were 30 patients with CFS and 40 healthy controls; the groups were matched for age, sex, education, body mass index, and hours of moderate exercise/week. Questionnaires were used to obtain relevant medical and demographic information, and assess current symptoms and functional impairment. Electrocardiograms, perceived fatigue/effort and performance data were recorded during cognitive tasks. Between-group differences in autonomic reactivity and associations with cognitive performance were analysed.<h4>Results</h4>Patients with CFS showed no deficits in performance accuracy, but were significantly slower than healthy controls. CFS was further characterized by low and unresponsive HRV; greater heart rate (HR) reactivity and prolonged HR-recovery after cognitive challenge. Fatigue levels, perceived effort and distress did not affect cognitive performance. HRV was consistently associated with performance indices and significantly predicted variance in cognitive outcomes.<h4>Conclusions</h4>These findings reveal for the first time an association between reduced cardiac vagal tone and cognitive impairment in CFS and confirm previous reports of diminished vagal activity.
format	article
author	Alison Beaumont Alexander R Burton Jim Lemon Barbara K Bennett Andrew Lloyd Uté Vollmer-Conna
author_facet	Alison Beaumont Alexander R Burton Jim Lemon Barbara K Bennett Andrew Lloyd Uté Vollmer-Conna
author_sort	Alison Beaumont
title	Reduced cardiac vagal modulation impacts on cognitive performance in chronic fatigue syndrome.
title_short	Reduced cardiac vagal modulation impacts on cognitive performance in chronic fatigue syndrome.
title_full	Reduced cardiac vagal modulation impacts on cognitive performance in chronic fatigue syndrome.
title_fullStr	Reduced cardiac vagal modulation impacts on cognitive performance in chronic fatigue syndrome.
title_full_unstemmed	Reduced cardiac vagal modulation impacts on cognitive performance in chronic fatigue syndrome.
title_sort	reduced cardiac vagal modulation impacts on cognitive performance in chronic fatigue syndrome.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/ae8e0bdfda4447be8da5115121f5748a
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Reduced cardiac vagal modulation impacts on cognitive performance in chronic fatigue syndrome.

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