Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes

Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes

Pancreatic ductal adenocarcinoma (PDAC) is a complex disease and its underlying epigenomic heterogeneity is not fully understood. Here, the authors utilize patient-derived PDAC xenografts to define the epigenomic landscape of PDAC, highlighting chromatin states linked to differing disease aggressive...

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Autores principales: Gwen Lomberk, Yuna Blum, Rémy Nicolle, Asha Nair, Krutika Satish Gaonkar, Laetitia Marisa, Angela Mathison, Zhifu Sun, Huihuang Yan, Nabila Elarouci, Lucile Armenoult, Mira Ayadi, Tamas Ordog, Jeong-Heon Lee, Gavin Oliver, Eric Klee, Vincent Moutardier, Odile Gayet, Benjamin Bian, Pauline Duconseil, Marine Gilabert, Martin Bigonnet, Stephane Garcia, Olivier Turrini, Jean-Robert Delpero, Marc Giovannini, Philippe Grandval, Mohamed Gasmi, Veronique Secq, Aurélien De Reyniès, Nelson Dusetti, Juan Iovanna, Raul Urrutia
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/ae929c3ce359431a8440a2e7a864fc2f
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spelling oai:doaj.org-article:ae929c3ce359431a8440a2e7a864fc2f2021-12-02T14:40:03ZDistinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes10.1038/s41467-018-04383-62041-1723https://doaj.org/article/ae929c3ce359431a8440a2e7a864fc2f2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04383-6https://doaj.org/toc/2041-1723Pancreatic ductal adenocarcinoma (PDAC) is a complex disease and its underlying epigenomic heterogeneity is not fully understood. Here, the authors utilize patient-derived PDAC xenografts to define the epigenomic landscape of PDAC, highlighting chromatin states linked to differing disease aggressiveness and survival.Gwen LomberkYuna BlumRémy NicolleAsha NairKrutika Satish GaonkarLaetitia MarisaAngela MathisonZhifu SunHuihuang YanNabila ElarouciLucile ArmenoultMira AyadiTamas OrdogJeong-Heon LeeGavin OliverEric KleeVincent MoutardierOdile GayetBenjamin BianPauline DuconseilMarine GilabertMartin BigonnetStephane GarciaOlivier TurriniJean-Robert DelperoMarc GiovanniniPhilippe GrandvalMohamed GasmiVeronique SecqAurélien De ReynièsNelson DusettiJuan IovannaRaul UrrutiaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Gwen Lomberk
Yuna Blum
Rémy Nicolle
Asha Nair
Krutika Satish Gaonkar
Laetitia Marisa
Angela Mathison
Zhifu Sun
Huihuang Yan
Nabila Elarouci
Lucile Armenoult
Mira Ayadi
Tamas Ordog
Jeong-Heon Lee
Gavin Oliver
Eric Klee
Vincent Moutardier
Odile Gayet
Benjamin Bian
Pauline Duconseil
Marine Gilabert
Martin Bigonnet
Stephane Garcia
Olivier Turrini
Jean-Robert Delpero
Marc Giovannini
Philippe Grandval
Mohamed Gasmi
Veronique Secq
Aurélien De Reyniès
Nelson Dusetti
Juan Iovanna
Raul Urrutia
Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes
description Pancreatic ductal adenocarcinoma (PDAC) is a complex disease and its underlying epigenomic heterogeneity is not fully understood. Here, the authors utilize patient-derived PDAC xenografts to define the epigenomic landscape of PDAC, highlighting chromatin states linked to differing disease aggressiveness and survival.
format article
author Gwen Lomberk
Yuna Blum
Rémy Nicolle
Asha Nair
Krutika Satish Gaonkar
Laetitia Marisa
Angela Mathison
Zhifu Sun
Huihuang Yan
Nabila Elarouci
Lucile Armenoult
Mira Ayadi
Tamas Ordog
Jeong-Heon Lee
Gavin Oliver
Eric Klee
Vincent Moutardier
Odile Gayet
Benjamin Bian
Pauline Duconseil
Marine Gilabert
Martin Bigonnet
Stephane Garcia
Olivier Turrini
Jean-Robert Delpero
Marc Giovannini
Philippe Grandval
Mohamed Gasmi
Veronique Secq
Aurélien De Reyniès
Nelson Dusetti
Juan Iovanna
Raul Urrutia
author_facet Gwen Lomberk
Yuna Blum
Rémy Nicolle
Asha Nair
Krutika Satish Gaonkar
Laetitia Marisa
Angela Mathison
Zhifu Sun
Huihuang Yan
Nabila Elarouci
Lucile Armenoult
Mira Ayadi
Tamas Ordog
Jeong-Heon Lee
Gavin Oliver
Eric Klee
Vincent Moutardier
Odile Gayet
Benjamin Bian
Pauline Duconseil
Marine Gilabert
Martin Bigonnet
Stephane Garcia
Olivier Turrini
Jean-Robert Delpero
Marc Giovannini
Philippe Grandval
Mohamed Gasmi
Veronique Secq
Aurélien De Reyniès
Nelson Dusetti
Juan Iovanna
Raul Urrutia
author_sort Gwen Lomberk
title Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes
title_short Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes
title_full Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes
title_fullStr Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes
title_full_unstemmed Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes
title_sort distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/ae929c3ce359431a8440a2e7a864fc2f
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