Comparison of COVID-19 outcomes among shielded and non-shielded populations
Abstract Many western countries used shielding (extended self-isolation) of people presumed to be at high-risk from COVID-19 to protect them and reduce healthcare demand. To investigate the effectiveness of this strategy, we linked family practitioner, prescribing, laboratory, hospital and death rec...
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Nature Portfolio
2021
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oai:doaj.org-article:ae93bb33ae9d4e71972d630f2d8dc4c72021-12-02T16:24:52ZComparison of COVID-19 outcomes among shielded and non-shielded populations10.1038/s41598-021-94630-62045-2322https://doaj.org/article/ae93bb33ae9d4e71972d630f2d8dc4c72021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94630-6https://doaj.org/toc/2045-2322Abstract Many western countries used shielding (extended self-isolation) of people presumed to be at high-risk from COVID-19 to protect them and reduce healthcare demand. To investigate the effectiveness of this strategy, we linked family practitioner, prescribing, laboratory, hospital and death records and compared COVID-19 outcomes among shielded and non-shielded individuals in the West of Scotland. Of the 1.3 million population, 27,747 (2.03%) were advised to shield, and 353,085 (26.85%) were classified a priori as moderate risk. COVID-19 testing was more common in the shielded (7.01%) and moderate risk (2.03%) groups, than low risk (0.73%). Referent to low-risk, the shielded group had higher confirmed infections (RR 8.45, 95% 7.44–9.59), case-fatality (RR 5.62, 95% CI 4.47–7.07) and population mortality (RR 57.56, 95% 44.06–75.19). The moderate-risk had intermediate confirmed infections (RR 4.11, 95% CI 3.82–4.42) and population mortality (RR 25.41, 95% CI 20.36–31.71) but, due to their higher prevalence, made the largest contribution to deaths (PAF 75.30%). Age ≥ 70 years accounted for 49.55% of deaths. In conclusion, in spite of the shielding strategy, high risk individuals were at increased risk of death. Furthermore, to be effective as a population strategy, shielding criteria would have needed to be widely expanded to include other criteria, such as the elderly.Bhautesh D. JaniFrederick K. HoDavid J. LoweJamie P. TraynorSean P. MacBride-StewartPatrick B. MarkFrances S. MairJill P. PellNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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Medicine R Science Q Bhautesh D. Jani Frederick K. Ho David J. Lowe Jamie P. Traynor Sean P. MacBride-Stewart Patrick B. Mark Frances S. Mair Jill P. Pell Comparison of COVID-19 outcomes among shielded and non-shielded populations |
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Abstract Many western countries used shielding (extended self-isolation) of people presumed to be at high-risk from COVID-19 to protect them and reduce healthcare demand. To investigate the effectiveness of this strategy, we linked family practitioner, prescribing, laboratory, hospital and death records and compared COVID-19 outcomes among shielded and non-shielded individuals in the West of Scotland. Of the 1.3 million population, 27,747 (2.03%) were advised to shield, and 353,085 (26.85%) were classified a priori as moderate risk. COVID-19 testing was more common in the shielded (7.01%) and moderate risk (2.03%) groups, than low risk (0.73%). Referent to low-risk, the shielded group had higher confirmed infections (RR 8.45, 95% 7.44–9.59), case-fatality (RR 5.62, 95% CI 4.47–7.07) and population mortality (RR 57.56, 95% 44.06–75.19). The moderate-risk had intermediate confirmed infections (RR 4.11, 95% CI 3.82–4.42) and population mortality (RR 25.41, 95% CI 20.36–31.71) but, due to their higher prevalence, made the largest contribution to deaths (PAF 75.30%). Age ≥ 70 years accounted for 49.55% of deaths. In conclusion, in spite of the shielding strategy, high risk individuals were at increased risk of death. Furthermore, to be effective as a population strategy, shielding criteria would have needed to be widely expanded to include other criteria, such as the elderly. |
format |
article |
author |
Bhautesh D. Jani Frederick K. Ho David J. Lowe Jamie P. Traynor Sean P. MacBride-Stewart Patrick B. Mark Frances S. Mair Jill P. Pell |
author_facet |
Bhautesh D. Jani Frederick K. Ho David J. Lowe Jamie P. Traynor Sean P. MacBride-Stewart Patrick B. Mark Frances S. Mair Jill P. Pell |
author_sort |
Bhautesh D. Jani |
title |
Comparison of COVID-19 outcomes among shielded and non-shielded populations |
title_short |
Comparison of COVID-19 outcomes among shielded and non-shielded populations |
title_full |
Comparison of COVID-19 outcomes among shielded and non-shielded populations |
title_fullStr |
Comparison of COVID-19 outcomes among shielded and non-shielded populations |
title_full_unstemmed |
Comparison of COVID-19 outcomes among shielded and non-shielded populations |
title_sort |
comparison of covid-19 outcomes among shielded and non-shielded populations |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/ae93bb33ae9d4e71972d630f2d8dc4c7 |
work_keys_str_mv |
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