Mosaic mutations in blood DNA sequence are associated with solid tumor cancers

Cancer: Blood mutations linked to solid tumor risk Increased risk for solid tumors linked to mutations detected in blood samples that shorten the coding sequence of their genes. Mark Daly and colleagues from the Broad Institute in Cambridge, Massachusetts, USA, used large genomic databases to test w...

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Autores principales:	Mykyta Artomov, Manuel A. Rivas, Giulio Genovese, Mark J. Daly
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Genetics QH426-470
Acceso en línea:	https://doaj.org/article/ae9751892af14558bcb4094fc985db7c
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spelling	oai:doaj.org-article:ae9751892af14558bcb4094fc985db7c2021-12-02T12:34:18ZMosaic mutations in blood DNA sequence are associated with solid tumor cancers10.1038/s41525-017-0025-42056-7944https://doaj.org/article/ae9751892af14558bcb4094fc985db7c2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41525-017-0025-4https://doaj.org/toc/2056-7944Cancer: Blood mutations linked to solid tumor risk Increased risk for solid tumors linked to mutations detected in blood samples that shorten the coding sequence of their genes. Mark Daly and colleagues from the Broad Institute in Cambridge, Massachusetts, USA, used large genomic databases to test whether having blood cells both with and without genetic variants predicted to shorten the encoded protein—a phenomenon known as mosaic protein-truncating variants (PTVs)—was associated with developing a range of solid-tumor cancers. They studied DNA from around 8,000 people with cancer and 6,000 healthy controls. Other studies have shown that mosaic PTVs precede and predict the development of leukemia. In this study, the scientists not only confirmed previous reports linking these variants to breast and ovarian cancer but also extended the association to include tumors of the brain, skin and lungs. These results broadly connect cancer to blood DNA changes.Mykyta ArtomovManuel A. RivasGiulio GenoveseMark J. DalyNature PortfolioarticleMedicineRGeneticsQH426-470ENnpj Genomic Medicine, Vol 2, Iss 1, Pp 1-5 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Genetics QH426-470
spellingShingle	Medicine R Genetics QH426-470 Mykyta Artomov Manuel A. Rivas Giulio Genovese Mark J. Daly Mosaic mutations in blood DNA sequence are associated with solid tumor cancers
description	Cancer: Blood mutations linked to solid tumor risk Increased risk for solid tumors linked to mutations detected in blood samples that shorten the coding sequence of their genes. Mark Daly and colleagues from the Broad Institute in Cambridge, Massachusetts, USA, used large genomic databases to test whether having blood cells both with and without genetic variants predicted to shorten the encoded protein—a phenomenon known as mosaic protein-truncating variants (PTVs)—was associated with developing a range of solid-tumor cancers. They studied DNA from around 8,000 people with cancer and 6,000 healthy controls. Other studies have shown that mosaic PTVs precede and predict the development of leukemia. In this study, the scientists not only confirmed previous reports linking these variants to breast and ovarian cancer but also extended the association to include tumors of the brain, skin and lungs. These results broadly connect cancer to blood DNA changes.
format	article
author	Mykyta Artomov Manuel A. Rivas Giulio Genovese Mark J. Daly
author_facet	Mykyta Artomov Manuel A. Rivas Giulio Genovese Mark J. Daly
author_sort	Mykyta Artomov
title	Mosaic mutations in blood DNA sequence are associated with solid tumor cancers
title_short	Mosaic mutations in blood DNA sequence are associated with solid tumor cancers
title_full	Mosaic mutations in blood DNA sequence are associated with solid tumor cancers
title_fullStr	Mosaic mutations in blood DNA sequence are associated with solid tumor cancers
title_full_unstemmed	Mosaic mutations in blood DNA sequence are associated with solid tumor cancers
title_sort	mosaic mutations in blood dna sequence are associated with solid tumor cancers
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ae9751892af14558bcb4094fc985db7c
work_keys_str_mv	AT mykytaartomov mosaicmutationsinblooddnasequenceareassociatedwithsolidtumorcancers AT manuelarivas mosaicmutationsinblooddnasequenceareassociatedwithsolidtumorcancers AT giuliogenovese mosaicmutationsinblooddnasequenceareassociatedwithsolidtumorcancers AT markjdaly mosaicmutationsinblooddnasequenceareassociatedwithsolidtumorcancers
_version_	1718393879074439168

Mosaic mutations in blood DNA sequence are associated with solid tumor cancers

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