Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction

The actin-related protein (Arp)2/3 complex nucleates branched actin filament networks pivotal for cell migration, endocytosis and pathogen infection. Here, authors report a 9.0 Å resolution structure of the actin filament Arp2/3 complex branch junction in cells using cryo-electron tomography and sub...

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Autores principales: Florian Fäßler, Georgi Dimchev, Victor-Valentin Hodirnau, William Wan, Florian K. M. Schur
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/aea4b5581860408ab7a49586d9ca1cf8
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Sumario:The actin-related protein (Arp)2/3 complex nucleates branched actin filament networks pivotal for cell migration, endocytosis and pathogen infection. Here, authors report a 9.0 Å resolution structure of the actin filament Arp2/3 complex branch junction in cells using cryo-electron tomography and subtomogram averaging.