The clinical significance of vitamin D in systemic lupus erythematosus: a systematic review.

<h4>Background</h4>Vitamin D deficiency is more prevalent among SLE patients than the general population. Over the past decade, many studies across the globe have been carried out to investigate the role of vitamin D in SLE from various clinical angles. Therefore, the aim of this systema...

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Autores principales:	Rajalingham Sakthiswary, Azman Ali Raymond
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aea9f850e2bb4663bff7a9610846c098
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spelling	oai:doaj.org-article:aea9f850e2bb4663bff7a9610846c0982021-11-18T07:59:25ZThe clinical significance of vitamin D in systemic lupus erythematosus: a systematic review.1932-620310.1371/journal.pone.0055275https://doaj.org/article/aea9f850e2bb4663bff7a9610846c0982013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23383135/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Vitamin D deficiency is more prevalent among SLE patients than the general population. Over the past decade, many studies across the globe have been carried out to investigate the role of vitamin D in SLE from various clinical angles. Therefore, the aim of this systematic review is to summarise and evaluate the evidence from the published literature; focusing on the clinical significance of vitamin D in SLE.<h4>Methods</h4>THE FOLLOWING DATABASES WERE SEARCHED: MEDLINE, Scopus, Web of Knowledge and CINAHL, using the terms "lupus", "systemic lupus erythematosus", "SLE and "vitamin D". We included only adult human studies published in the English language between 2000 and 2012.The reference lists of included studies were thoroughly reviewed in search for other relevant studies.<h4>Results</h4>A total of 22 studies met the selection criteria. The majority of the studies were observational (95.5%) and cross sectional (90.9%). Out of the 15 studies which looked into the association between vitamin D and SLE disease activity, 10 studies (including the 3 largest studies in this series) revealed a statistically significant inverse relationship. For disease damage, on the other hand, 5 out of 6 studies failed to demonstrate any association with vitamin D levels. Cardiovascular risk factors such as insulin resistance, hypertension and hypercholesterolaemia were related to vitamin D deficiency, according to 3 of the studies.<h4>Conclusion</h4>There is convincing evidence to support the association between vitamin D levels and SLE disease activity. There is paucity of data in other clinical aspects to make firm conclusions.Rajalingham SakthiswaryAzman Ali RaymondPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e55275 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rajalingham Sakthiswary Azman Ali Raymond The clinical significance of vitamin D in systemic lupus erythematosus: a systematic review.
description	<h4>Background</h4>Vitamin D deficiency is more prevalent among SLE patients than the general population. Over the past decade, many studies across the globe have been carried out to investigate the role of vitamin D in SLE from various clinical angles. Therefore, the aim of this systematic review is to summarise and evaluate the evidence from the published literature; focusing on the clinical significance of vitamin D in SLE.<h4>Methods</h4>THE FOLLOWING DATABASES WERE SEARCHED: MEDLINE, Scopus, Web of Knowledge and CINAHL, using the terms "lupus", "systemic lupus erythematosus", "SLE and "vitamin D". We included only adult human studies published in the English language between 2000 and 2012.The reference lists of included studies were thoroughly reviewed in search for other relevant studies.<h4>Results</h4>A total of 22 studies met the selection criteria. The majority of the studies were observational (95.5%) and cross sectional (90.9%). Out of the 15 studies which looked into the association between vitamin D and SLE disease activity, 10 studies (including the 3 largest studies in this series) revealed a statistically significant inverse relationship. For disease damage, on the other hand, 5 out of 6 studies failed to demonstrate any association with vitamin D levels. Cardiovascular risk factors such as insulin resistance, hypertension and hypercholesterolaemia were related to vitamin D deficiency, according to 3 of the studies.<h4>Conclusion</h4>There is convincing evidence to support the association between vitamin D levels and SLE disease activity. There is paucity of data in other clinical aspects to make firm conclusions.
format	article
author	Rajalingham Sakthiswary Azman Ali Raymond
author_facet	Rajalingham Sakthiswary Azman Ali Raymond
author_sort	Rajalingham Sakthiswary
title	The clinical significance of vitamin D in systemic lupus erythematosus: a systematic review.
title_short	The clinical significance of vitamin D in systemic lupus erythematosus: a systematic review.
title_full	The clinical significance of vitamin D in systemic lupus erythematosus: a systematic review.
title_fullStr	The clinical significance of vitamin D in systemic lupus erythematosus: a systematic review.
title_full_unstemmed	The clinical significance of vitamin D in systemic lupus erythematosus: a systematic review.
title_sort	clinical significance of vitamin d in systemic lupus erythematosus: a systematic review.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/aea9f850e2bb4663bff7a9610846c098
work_keys_str_mv	AT rajalinghamsakthiswary theclinicalsignificanceofvitamindinsystemiclupuserythematosusasystematicreview AT azmanaliraymond theclinicalsignificanceofvitamindinsystemiclupuserythematosusasystematicreview AT rajalinghamsakthiswary clinicalsignificanceofvitamindinsystemiclupuserythematosusasystematicreview AT azmanaliraymond clinicalsignificanceofvitamindinsystemiclupuserythematosusasystematicreview
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The clinical significance of vitamin D in systemic lupus erythematosus: a systematic review.

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