hReg-CNCC reconstructs a regulatory network in human cranial neural crest cells and annotates variants in a developmental context

Zhanying Feng et al. present hReg-CNCC, a high-quality gene regulatory network for human cranial neural crest cells (CNCCs) constructed by consensus optimization modeling. It may be useful in interpreting genetic variants involved in embryonic development by linking the cis-regulatory sequences in t...

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Autores principales:	Zhanying Feng, Zhana Duren, Ziyi Xiong, Sijia Wang, Fan Liu, Wing Hung Wong, Yong Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/aeaa0ebe7bf64e44ac0759281f751e18
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spelling	oai:doaj.org-article:aeaa0ebe7bf64e44ac0759281f751e182021-12-02T18:15:35ZhReg-CNCC reconstructs a regulatory network in human cranial neural crest cells and annotates variants in a developmental context10.1038/s42003-021-01970-02399-3642https://doaj.org/article/aeaa0ebe7bf64e44ac0759281f751e182021-04-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01970-0https://doaj.org/toc/2399-3642Zhanying Feng et al. present hReg-CNCC, a high-quality gene regulatory network for human cranial neural crest cells (CNCCs) constructed by consensus optimization modeling. It may be useful in interpreting genetic variants involved in embryonic development by linking the cis-regulatory sequences in this network with GWAS SNPs, disease risk loci, and evolutionarily-conserved regions of the genome.Zhanying FengZhana DurenZiyi XiongSijia WangFan LiuWing Hung WongYong WangNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Zhanying Feng Zhana Duren Ziyi Xiong Sijia Wang Fan Liu Wing Hung Wong Yong Wang hReg-CNCC reconstructs a regulatory network in human cranial neural crest cells and annotates variants in a developmental context
description	Zhanying Feng et al. present hReg-CNCC, a high-quality gene regulatory network for human cranial neural crest cells (CNCCs) constructed by consensus optimization modeling. It may be useful in interpreting genetic variants involved in embryonic development by linking the cis-regulatory sequences in this network with GWAS SNPs, disease risk loci, and evolutionarily-conserved regions of the genome.
format	article
author	Zhanying Feng Zhana Duren Ziyi Xiong Sijia Wang Fan Liu Wing Hung Wong Yong Wang
author_facet	Zhanying Feng Zhana Duren Ziyi Xiong Sijia Wang Fan Liu Wing Hung Wong Yong Wang
author_sort	Zhanying Feng
title	hReg-CNCC reconstructs a regulatory network in human cranial neural crest cells and annotates variants in a developmental context
title_short	hReg-CNCC reconstructs a regulatory network in human cranial neural crest cells and annotates variants in a developmental context
title_full	hReg-CNCC reconstructs a regulatory network in human cranial neural crest cells and annotates variants in a developmental context
title_fullStr	hReg-CNCC reconstructs a regulatory network in human cranial neural crest cells and annotates variants in a developmental context
title_full_unstemmed	hReg-CNCC reconstructs a regulatory network in human cranial neural crest cells and annotates variants in a developmental context
title_sort	hreg-cncc reconstructs a regulatory network in human cranial neural crest cells and annotates variants in a developmental context
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/aeaa0ebe7bf64e44ac0759281f751e18
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hReg-CNCC reconstructs a regulatory network in human cranial neural crest cells and annotates variants in a developmental context

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