Mesenchymal Stromal Cell Secretome for the Treatment of Immune-Mediated Inflammatory Diseases: Latest Trends in Isolation, Content Optimization and Delivery Avenues

Considering the high prevalence and the complex pharmacological management of immune-mediated inflammatory diseases (IMIDs), the search for new therapeutic approaches for their treatment is vital. Although the immunomodulatory and anti-inflammatory effects of mesenchymal stromal cells (MSCs) have be...

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Autores principales:	Elena Munoz-Perez, Ainhoa Gonzalez-Pujana, Manoli Igartua, Edorta Santos-Vizcaino, Rosa Maria Hernandez
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	MSCs secretome hydrogel extracellular vesicles exosomes immunomodulation Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/aeaede7b330b442696fca9340f75dc09
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spelling	oai:doaj.org-article:aeaede7b330b442696fca9340f75dc092021-11-25T18:40:48ZMesenchymal Stromal Cell Secretome for the Treatment of Immune-Mediated Inflammatory Diseases: Latest Trends in Isolation, Content Optimization and Delivery Avenues10.3390/pharmaceutics131118021999-4923https://doaj.org/article/aeaede7b330b442696fca9340f75dc092021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1802https://doaj.org/toc/1999-4923Considering the high prevalence and the complex pharmacological management of immune-mediated inflammatory diseases (IMIDs), the search for new therapeutic approaches for their treatment is vital. Although the immunomodulatory and anti-inflammatory effects of mesenchymal stromal cells (MSCs) have been extensively studied as a potential therapy in this field, direct MSC implantation presents some limitations that could slow down the clinical translation. Since the beneficial effects of MSCs have been mainly attributed to their ability to secrete a plethora of bioactive factors, their secretome has been proposed as a new and promising pathway for the treatment of IMIDs. Formed from soluble factors and extracellular vesicles (EVs), the MSC-derived secretome has been proven to elicit immunomodulatory effects that control the inflammatory processes that occur in IMIDs. This article aims to review the available knowledge on the MSC secretome, evaluating the advances in this field in terms of its composition, production and application, as well as analyzing the pending challenges in the field. Moreover, the latest research involving secretome administration in IMIDs is discussed to provide an updated state-of-the-art for this field. Finally, novel secretome delivery alternatives are reviewed, paying special attention to hydrogel encapsulation as one of the most convenient and promising strategies.Elena Munoz-PerezAinhoa Gonzalez-PujanaManoli IgartuaEdorta Santos-VizcainoRosa Maria HernandezMDPI AGarticleMSCssecretomehydrogelextracellular vesiclesexosomesimmunomodulationPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1802, p 1802 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	MSCs secretome hydrogel extracellular vesicles exosomes immunomodulation Pharmacy and materia medica RS1-441
spellingShingle	MSCs secretome hydrogel extracellular vesicles exosomes immunomodulation Pharmacy and materia medica RS1-441 Elena Munoz-Perez Ainhoa Gonzalez-Pujana Manoli Igartua Edorta Santos-Vizcaino Rosa Maria Hernandez Mesenchymal Stromal Cell Secretome for the Treatment of Immune-Mediated Inflammatory Diseases: Latest Trends in Isolation, Content Optimization and Delivery Avenues
description	Considering the high prevalence and the complex pharmacological management of immune-mediated inflammatory diseases (IMIDs), the search for new therapeutic approaches for their treatment is vital. Although the immunomodulatory and anti-inflammatory effects of mesenchymal stromal cells (MSCs) have been extensively studied as a potential therapy in this field, direct MSC implantation presents some limitations that could slow down the clinical translation. Since the beneficial effects of MSCs have been mainly attributed to their ability to secrete a plethora of bioactive factors, their secretome has been proposed as a new and promising pathway for the treatment of IMIDs. Formed from soluble factors and extracellular vesicles (EVs), the MSC-derived secretome has been proven to elicit immunomodulatory effects that control the inflammatory processes that occur in IMIDs. This article aims to review the available knowledge on the MSC secretome, evaluating the advances in this field in terms of its composition, production and application, as well as analyzing the pending challenges in the field. Moreover, the latest research involving secretome administration in IMIDs is discussed to provide an updated state-of-the-art for this field. Finally, novel secretome delivery alternatives are reviewed, paying special attention to hydrogel encapsulation as one of the most convenient and promising strategies.
format	article
author	Elena Munoz-Perez Ainhoa Gonzalez-Pujana Manoli Igartua Edorta Santos-Vizcaino Rosa Maria Hernandez
author_facet	Elena Munoz-Perez Ainhoa Gonzalez-Pujana Manoli Igartua Edorta Santos-Vizcaino Rosa Maria Hernandez
author_sort	Elena Munoz-Perez
title	Mesenchymal Stromal Cell Secretome for the Treatment of Immune-Mediated Inflammatory Diseases: Latest Trends in Isolation, Content Optimization and Delivery Avenues
title_short	Mesenchymal Stromal Cell Secretome for the Treatment of Immune-Mediated Inflammatory Diseases: Latest Trends in Isolation, Content Optimization and Delivery Avenues
title_full	Mesenchymal Stromal Cell Secretome for the Treatment of Immune-Mediated Inflammatory Diseases: Latest Trends in Isolation, Content Optimization and Delivery Avenues
title_fullStr	Mesenchymal Stromal Cell Secretome for the Treatment of Immune-Mediated Inflammatory Diseases: Latest Trends in Isolation, Content Optimization and Delivery Avenues
title_full_unstemmed	Mesenchymal Stromal Cell Secretome for the Treatment of Immune-Mediated Inflammatory Diseases: Latest Trends in Isolation, Content Optimization and Delivery Avenues
title_sort	mesenchymal stromal cell secretome for the treatment of immune-mediated inflammatory diseases: latest trends in isolation, content optimization and delivery avenues
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/aeaede7b330b442696fca9340f75dc09
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Mesenchymal Stromal Cell Secretome for the Treatment of Immune-Mediated Inflammatory Diseases: Latest Trends in Isolation, Content Optimization and Delivery Avenues

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