Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma

Dermal myofibroblasts are responsible for fibrosis development in scleroderma. Here the authors show that a bioengineered recombinant human TRAIL ligand reverses established fibrosis in mouse models of scleroderma by targeting the death receptor 5 and inducing apoptosis of myofibroblasts.

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Autores principales:	Jong-Sung Park, Yumin Oh, Yong Joo Park, Ogyi Park, Hoseong Yang, Stephanie Slania, Laura K. Hummers, Ami A. Shah, Hyoung-Tae An, Jiyeon Jang, Maureen R. Horton, Joseph Shin, Harry C. Dietz, Eric Song, Dong Hee Na, Eun Ji Park, Kwangmeyung Kim, Kang Choon Lee, Viktor V. Roschke, Justin Hanes, Martin G. Pomper, Seulki Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/aeaf85cf976741ac932eb66d3a30c13f
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spelling	oai:doaj.org-article:aeaf85cf976741ac932eb66d3a30c13f2021-12-02T17:01:45ZTargeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma10.1038/s41467-019-09101-42041-1723https://doaj.org/article/aeaf85cf976741ac932eb66d3a30c13f2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09101-4https://doaj.org/toc/2041-1723Dermal myofibroblasts are responsible for fibrosis development in scleroderma. Here the authors show that a bioengineered recombinant human TRAIL ligand reverses established fibrosis in mouse models of scleroderma by targeting the death receptor 5 and inducing apoptosis of myofibroblasts.Jong-Sung ParkYumin OhYong Joo ParkOgyi ParkHoseong YangStephanie SlaniaLaura K. HummersAmi A. ShahHyoung-Tae AnJiyeon JangMaureen R. HortonJoseph ShinHarry C. DietzEric SongDong Hee NaEun Ji ParkKwangmeyung KimKang Choon LeeViktor V. RoschkeJustin HanesMartin G. PomperSeulki LeeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jong-Sung Park Yumin Oh Yong Joo Park Ogyi Park Hoseong Yang Stephanie Slania Laura K. Hummers Ami A. Shah Hyoung-Tae An Jiyeon Jang Maureen R. Horton Joseph Shin Harry C. Dietz Eric Song Dong Hee Na Eun Ji Park Kwangmeyung Kim Kang Choon Lee Viktor V. Roschke Justin Hanes Martin G. Pomper Seulki Lee Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma
description	Dermal myofibroblasts are responsible for fibrosis development in scleroderma. Here the authors show that a bioengineered recombinant human TRAIL ligand reverses established fibrosis in mouse models of scleroderma by targeting the death receptor 5 and inducing apoptosis of myofibroblasts.
format	article
author	Jong-Sung Park Yumin Oh Yong Joo Park Ogyi Park Hoseong Yang Stephanie Slania Laura K. Hummers Ami A. Shah Hyoung-Tae An Jiyeon Jang Maureen R. Horton Joseph Shin Harry C. Dietz Eric Song Dong Hee Na Eun Ji Park Kwangmeyung Kim Kang Choon Lee Viktor V. Roschke Justin Hanes Martin G. Pomper Seulki Lee
author_facet	Jong-Sung Park Yumin Oh Yong Joo Park Ogyi Park Hoseong Yang Stephanie Slania Laura K. Hummers Ami A. Shah Hyoung-Tae An Jiyeon Jang Maureen R. Horton Joseph Shin Harry C. Dietz Eric Song Dong Hee Na Eun Ji Park Kwangmeyung Kim Kang Choon Lee Viktor V. Roschke Justin Hanes Martin G. Pomper Seulki Lee
author_sort	Jong-Sung Park
title	Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma
title_short	Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma
title_full	Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma
title_fullStr	Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma
title_full_unstemmed	Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma
title_sort	targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/aeaf85cf976741ac932eb66d3a30c13f
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_version_	1718382046249746432

Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma

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