Comparative gene-expression profiling of the large cell variant of gastrointestinal marginal-zone B-cell lymphoma

Abstract Gastrointestinal (g.i.) large cell lymphoma is currently regarded as diffuse large B-cell lymphoma (DLBCL) despite a more favorable clinical outcome compared to other DLBCL. Cluster analyses on a transcriptome signature of NF-κB target genes of 30 g.i. marginal zone B-cell lymphomas (MZBL;...

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Autores principales:	Thomas F. E. Barth, Johann M. Kraus, Ludwig Lausser, Lucia Flossbach, Lukas Schulte, Karlheinz Holzmann, Hans A. Kestler, Peter Möller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aeb0042fc4ca4e78b7d15c3d5f7ca3ca
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spelling	oai:doaj.org-article:aeb0042fc4ca4e78b7d15c3d5f7ca3ca2021-12-02T11:40:14ZComparative gene-expression profiling of the large cell variant of gastrointestinal marginal-zone B-cell lymphoma10.1038/s41598-017-05116-32045-2322https://doaj.org/article/aeb0042fc4ca4e78b7d15c3d5f7ca3ca2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05116-3https://doaj.org/toc/2045-2322Abstract Gastrointestinal (g.i.) large cell lymphoma is currently regarded as diffuse large B-cell lymphoma (DLBCL) despite a more favorable clinical outcome compared to other DLBCL. Cluster analyses on a transcriptome signature of NF-κB target genes of 30 g.i. marginal zone B-cell lymphomas (MZBL; 8 g.i. MZBL, 22 large cell MZBL - among them 9 with coexisting small cell component) and 6 DLBCL (3 activated B-cell like (ABC), 3 germinal center-like (GCB)) reveals a distinct pattern. The distinctiveness of large cell MZBL samples is further confirmed by a cohort of 270 available B-cell lymphoma and B-cell in silico profiles. Of the NF-κB genes analyzed, c-REL was overexpressed in g.i. MZBL. c-REL amplification was limited to 6/22 large cell MZBL including the large cell component of 2/9 composite small cell/large cell lymphomas, and c-Rel protein expression was found in the large cell compartment of composite lymphomas. Classification experiments on DLBCL and large cell MZBL profiles support the concept that the large cell MZBL is a distinct type of B-cell lymphoma.Thomas F. E. BarthJohann M. KrausLudwig LausserLucia FlossbachLukas SchulteKarlheinz HolzmannHans A. KestlerPeter MöllerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Thomas F. E. Barth Johann M. Kraus Ludwig Lausser Lucia Flossbach Lukas Schulte Karlheinz Holzmann Hans A. Kestler Peter Möller Comparative gene-expression profiling of the large cell variant of gastrointestinal marginal-zone B-cell lymphoma
description	Abstract Gastrointestinal (g.i.) large cell lymphoma is currently regarded as diffuse large B-cell lymphoma (DLBCL) despite a more favorable clinical outcome compared to other DLBCL. Cluster analyses on a transcriptome signature of NF-κB target genes of 30 g.i. marginal zone B-cell lymphomas (MZBL; 8 g.i. MZBL, 22 large cell MZBL - among them 9 with coexisting small cell component) and 6 DLBCL (3 activated B-cell like (ABC), 3 germinal center-like (GCB)) reveals a distinct pattern. The distinctiveness of large cell MZBL samples is further confirmed by a cohort of 270 available B-cell lymphoma and B-cell in silico profiles. Of the NF-κB genes analyzed, c-REL was overexpressed in g.i. MZBL. c-REL amplification was limited to 6/22 large cell MZBL including the large cell component of 2/9 composite small cell/large cell lymphomas, and c-Rel protein expression was found in the large cell compartment of composite lymphomas. Classification experiments on DLBCL and large cell MZBL profiles support the concept that the large cell MZBL is a distinct type of B-cell lymphoma.
format	article
author	Thomas F. E. Barth Johann M. Kraus Ludwig Lausser Lucia Flossbach Lukas Schulte Karlheinz Holzmann Hans A. Kestler Peter Möller
author_facet	Thomas F. E. Barth Johann M. Kraus Ludwig Lausser Lucia Flossbach Lukas Schulte Karlheinz Holzmann Hans A. Kestler Peter Möller
author_sort	Thomas F. E. Barth
title	Comparative gene-expression profiling of the large cell variant of gastrointestinal marginal-zone B-cell lymphoma
title_short	Comparative gene-expression profiling of the large cell variant of gastrointestinal marginal-zone B-cell lymphoma
title_full	Comparative gene-expression profiling of the large cell variant of gastrointestinal marginal-zone B-cell lymphoma
title_fullStr	Comparative gene-expression profiling of the large cell variant of gastrointestinal marginal-zone B-cell lymphoma
title_full_unstemmed	Comparative gene-expression profiling of the large cell variant of gastrointestinal marginal-zone B-cell lymphoma
title_sort	comparative gene-expression profiling of the large cell variant of gastrointestinal marginal-zone b-cell lymphoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/aeb0042fc4ca4e78b7d15c3d5f7ca3ca
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Comparative gene-expression profiling of the large cell variant of gastrointestinal marginal-zone B-cell lymphoma

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