Disability in patients consulting for anxiety or mood disorders in primary care: response to antidepressant treatment

Alain G&eacute;rard,1 Fran&ccedil;ois Liard,2 Anne Crochard,3 Sylvia Goni,3 Bruno Millet41Rue des Marronniers&rsquo; Psychiatry Clinic, Paris; 2General Practice, Saint Epain, 3Medical Affairs Department, Laboratoire Lundbeck SAS, Issy-Les-Moulineaux, 4Psychiatry Department, G...

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Autores principales:	G&eacute;rard A, Liard F, Crochard A, Goni S, Millet B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/aeb288a345a6478b92e6d1358f9d0130
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spelling	oai:doaj.org-article:aeb288a345a6478b92e6d1358f9d01302021-12-02T07:20:37ZDisability in patients consulting for anxiety or mood disorders in primary care: response to antidepressant treatment1176-63281178-2021https://doaj.org/article/aeb288a345a6478b92e6d1358f9d01302012-12-01T00:00:00Zhttp://www.dovepress.com/disability-in-patients-consulting-for-anxiety-or-mood-disorders-in-pri-a11739https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Alain G&eacute;rard,1 Fran&ccedil;ois Liard,2 Anne Crochard,3 Sylvia Goni,3 Bruno Millet41Rue des Marronniers&rsquo; Psychiatry Clinic, Paris; 2General Practice, Saint Epain, 3Medical Affairs Department, Laboratoire Lundbeck SAS, Issy-Les-Moulineaux, 4Psychiatry Department, Guillaume Regner University Hospital, University of Rennes 1, Rennes, FranceBackground: The primary objective of this prospective observational study was to evaluate changes in self-reported disability in patients with anxiety or mood disorders 3 months after initiating antidepressant treatment.Methods: This study included 8396 patients consulting 2433 general practitioners in France for a major mood episode, generalized anxiety disorder, social anxiety disorder, panic disorder, or obsessive-compulsive disorder. Treatment was initiated with the antidepressant that the physician considered appropriate. Patients were evaluated with the Sheehan Disability Scale (SDS), Hospital Anxiety and Depression Scale, and Clinical Global Impression-Severity (CGI-S) at baseline and after 6 and 12 weeks.Results: At 12 weeks, 6617 patients (78.8%) were evaluable. At inclusion, the mean SDS subscores were 6.5 &plusmn; 2.2 on the work/school activities dimension, 6.8 &plusmn; 1.9 on the social activities dimension, and 6.5 &plusmn; 2.0 on the family life dimension. At the 12-week follow-up visit, the mean change in score on these three dimensions was -3.9 &plusmn; 2.6, -4.2 &plusmn; 2.5, and -4.0 &plusmn; 2.5, respectively. At the 12-week follow-up visit, 90.0% of patients were responders (defined as patients whose SDS dimension scores decreased by at least one point) on the work/school SDS subscores; 92.8% were responders on the social life SDS subscores, and 91.1% were responders on family life/home responsibilities SDS subscores. Functional remission (defined as an SDS subscore of 0 at study end) rates were 18.0% for the work/school dimension, 16.8% for the social activities dimension, and 19.5% for the family life dimension. Using a cutoff of &le;2, remission rates were 56.8%, 55.0%, and 58.0%, respectively. Improvements in self-rated disability were correlated with improvements in symptoms measured with clinician-rated CGI-S.Conclusion: Patients consulting for anxiety or mood disorders report significant disability, which can be effectively reduced by antidepressant treatment.Keywords: depression, anxiety disorder, antidepressant, disabilityG&eacute;rard ALiard FCrochard AGoni SMillet BDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2012, Iss default, Pp 605-614 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 G&eacute;rard A Liard F Crochard A Goni S Millet B Disability in patients consulting for anxiety or mood disorders in primary care: response to antidepressant treatment
description	Alain G&eacute;rard,1 Fran&ccedil;ois Liard,2 Anne Crochard,3 Sylvia Goni,3 Bruno Millet41Rue des Marronniers&rsquo; Psychiatry Clinic, Paris; 2General Practice, Saint Epain, 3Medical Affairs Department, Laboratoire Lundbeck SAS, Issy-Les-Moulineaux, 4Psychiatry Department, Guillaume Regner University Hospital, University of Rennes 1, Rennes, FranceBackground: The primary objective of this prospective observational study was to evaluate changes in self-reported disability in patients with anxiety or mood disorders 3 months after initiating antidepressant treatment.Methods: This study included 8396 patients consulting 2433 general practitioners in France for a major mood episode, generalized anxiety disorder, social anxiety disorder, panic disorder, or obsessive-compulsive disorder. Treatment was initiated with the antidepressant that the physician considered appropriate. Patients were evaluated with the Sheehan Disability Scale (SDS), Hospital Anxiety and Depression Scale, and Clinical Global Impression-Severity (CGI-S) at baseline and after 6 and 12 weeks.Results: At 12 weeks, 6617 patients (78.8%) were evaluable. At inclusion, the mean SDS subscores were 6.5 &plusmn; 2.2 on the work/school activities dimension, 6.8 &plusmn; 1.9 on the social activities dimension, and 6.5 &plusmn; 2.0 on the family life dimension. At the 12-week follow-up visit, the mean change in score on these three dimensions was -3.9 &plusmn; 2.6, -4.2 &plusmn; 2.5, and -4.0 &plusmn; 2.5, respectively. At the 12-week follow-up visit, 90.0% of patients were responders (defined as patients whose SDS dimension scores decreased by at least one point) on the work/school SDS subscores; 92.8% were responders on the social life SDS subscores, and 91.1% were responders on family life/home responsibilities SDS subscores. Functional remission (defined as an SDS subscore of 0 at study end) rates were 18.0% for the work/school dimension, 16.8% for the social activities dimension, and 19.5% for the family life dimension. Using a cutoff of &le;2, remission rates were 56.8%, 55.0%, and 58.0%, respectively. Improvements in self-rated disability were correlated with improvements in symptoms measured with clinician-rated CGI-S.Conclusion: Patients consulting for anxiety or mood disorders report significant disability, which can be effectively reduced by antidepressant treatment.Keywords: depression, anxiety disorder, antidepressant, disability
format	article
author	G&eacute;rard A Liard F Crochard A Goni S Millet B
author_facet	G&eacute;rard A Liard F Crochard A Goni S Millet B
author_sort	G&eacute;rard A
title	Disability in patients consulting for anxiety or mood disorders in primary care: response to antidepressant treatment
title_short	Disability in patients consulting for anxiety or mood disorders in primary care: response to antidepressant treatment
title_full	Disability in patients consulting for anxiety or mood disorders in primary care: response to antidepressant treatment
title_fullStr	Disability in patients consulting for anxiety or mood disorders in primary care: response to antidepressant treatment
title_full_unstemmed	Disability in patients consulting for anxiety or mood disorders in primary care: response to antidepressant treatment
title_sort	disability in patients consulting for anxiety or mood disorders in primary care: response to antidepressant treatment
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/aeb288a345a6478b92e6d1358f9d0130
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Disability in patients consulting for anxiety or mood disorders in primary care: response to antidepressant treatment

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