Adverse effects of iron deficiency anemia on pregnancy outcome and offspring development and intervention of three iron supplements

Abstract Iron deficiency anemia (IDA) is a common micronutrient deficiency among pregnant women with severe consequences including impaired immuno-inflammatory system, premature birth, fetal death etc. The present study aimed to investigate the effects of three iron supplements on IDA female rats an...

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Autores principales:	Qi Zhang, Xiao-Min Lu, Min Zhang, Chen-Ying Yang, Si-Yuan Lv, Shi-Fen Li, Cai-Yun Zhong, Shan-Shan Geng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aeb2ccc768bd4d978629572c23db89e1
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spelling	oai:doaj.org-article:aeb2ccc768bd4d978629572c23db89e12021-12-02T14:12:45ZAdverse effects of iron deficiency anemia on pregnancy outcome and offspring development and intervention of three iron supplements10.1038/s41598-020-79971-y2045-2322https://doaj.org/article/aeb2ccc768bd4d978629572c23db89e12021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79971-yhttps://doaj.org/toc/2045-2322Abstract Iron deficiency anemia (IDA) is a common micronutrient deficiency among pregnant women with severe consequences including impaired immuno-inflammatory system, premature birth, fetal death etc. The present study aimed to investigate the effects of three iron supplements on IDA female rats and their offspring. The IDA female rat model was established with low iron diet and the rats were then mated. After pregnancy, rats were fed diets containing different iron supplements (iron polysaccharide complex, iron protein succinylate and ferrous sulfate) until their offspring were 42 days old. Pregnancy outcomes, haematological, iron metabolism, physical and neurological development indexes were determined. The results showed that all three iron supplements improved the levels of hematological parameters of both mother and offspring rats. After iron supplementation, serum iron, transferrin saturation and serum ferritin levels were increased compared with the IDA group. The level of ferritin light chain in the liver and spleen of both mother and offspring rats in iron supplemented groups was significantly higher than that of the IDA group. The average number of born alive per litter in the iron treatment groups was significantly higher than that in the IDA group. Iron supplements also improved the physical growth and neurobehavioral development of offspring rats. It was also found that iron supplementation improved the expression of ferritin light chain and the synaptic growth associated proteins in the brain and hippocampus. No significant difference was found in the efficacy of three iron supplements. These results suggest that pregnant and postpartum IDA affects pregnancy outcomes, offspring physical development and causes neural impairment. Sufficient iron supplementation can significantly improve IDA and its adverse effects on both mother and offspring.Qi ZhangXiao-Min LuMin ZhangChen-Ying YangSi-Yuan LvShi-Fen LiCai-Yun ZhongShan-Shan GengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qi Zhang Xiao-Min Lu Min Zhang Chen-Ying Yang Si-Yuan Lv Shi-Fen Li Cai-Yun Zhong Shan-Shan Geng Adverse effects of iron deficiency anemia on pregnancy outcome and offspring development and intervention of three iron supplements
description	Abstract Iron deficiency anemia (IDA) is a common micronutrient deficiency among pregnant women with severe consequences including impaired immuno-inflammatory system, premature birth, fetal death etc. The present study aimed to investigate the effects of three iron supplements on IDA female rats and their offspring. The IDA female rat model was established with low iron diet and the rats were then mated. After pregnancy, rats were fed diets containing different iron supplements (iron polysaccharide complex, iron protein succinylate and ferrous sulfate) until their offspring were 42 days old. Pregnancy outcomes, haematological, iron metabolism, physical and neurological development indexes were determined. The results showed that all three iron supplements improved the levels of hematological parameters of both mother and offspring rats. After iron supplementation, serum iron, transferrin saturation and serum ferritin levels were increased compared with the IDA group. The level of ferritin light chain in the liver and spleen of both mother and offspring rats in iron supplemented groups was significantly higher than that of the IDA group. The average number of born alive per litter in the iron treatment groups was significantly higher than that in the IDA group. Iron supplements also improved the physical growth and neurobehavioral development of offspring rats. It was also found that iron supplementation improved the expression of ferritin light chain and the synaptic growth associated proteins in the brain and hippocampus. No significant difference was found in the efficacy of three iron supplements. These results suggest that pregnant and postpartum IDA affects pregnancy outcomes, offspring physical development and causes neural impairment. Sufficient iron supplementation can significantly improve IDA and its adverse effects on both mother and offspring.
format	article
author	Qi Zhang Xiao-Min Lu Min Zhang Chen-Ying Yang Si-Yuan Lv Shi-Fen Li Cai-Yun Zhong Shan-Shan Geng
author_facet	Qi Zhang Xiao-Min Lu Min Zhang Chen-Ying Yang Si-Yuan Lv Shi-Fen Li Cai-Yun Zhong Shan-Shan Geng
author_sort	Qi Zhang
title	Adverse effects of iron deficiency anemia on pregnancy outcome and offspring development and intervention of three iron supplements
title_short	Adverse effects of iron deficiency anemia on pregnancy outcome and offspring development and intervention of three iron supplements
title_full	Adverse effects of iron deficiency anemia on pregnancy outcome and offspring development and intervention of three iron supplements
title_fullStr	Adverse effects of iron deficiency anemia on pregnancy outcome and offspring development and intervention of three iron supplements
title_full_unstemmed	Adverse effects of iron deficiency anemia on pregnancy outcome and offspring development and intervention of three iron supplements
title_sort	adverse effects of iron deficiency anemia on pregnancy outcome and offspring development and intervention of three iron supplements
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/aeb2ccc768bd4d978629572c23db89e1
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Adverse effects of iron deficiency anemia on pregnancy outcome and offspring development and intervention of three iron supplements

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