Regulatory Mechanism of PD-L1 Expression in Primary Liver Cancer

The application of immunotherapy has become a hot spot in tumor research currently. In particular, immune checkpoint inhibitors have played an important role in the treatment of advanced unresectable primary liver cancer. However, the efficacy of immune checkpoint inhibitors varies greatly in the tr...

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Autores principales:	LI Shenghao, SHI Xinli
Formato:	article
Lenguaje:	ZH
Publicado:	Magazine House of Cancer Research on Prevention and Treatment 2021
Materias:	primary liver cancer pd-l1 immunotherapy regulatory mechanism Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/aeb6ca2b49204a9f9fbb56777e5f963a
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spelling	oai:doaj.org-article:aeb6ca2b49204a9f9fbb56777e5f963a2021-12-03T09:25:17ZRegulatory Mechanism of PD-L1 Expression in Primary Liver Cancer1000-857810.3971/j.issn.1000-8578.2021.21.0397https://doaj.org/article/aeb6ca2b49204a9f9fbb56777e5f963a2021-11-01T00:00:00Zhttp://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2021.21.0397https://doaj.org/toc/1000-8578The application of immunotherapy has become a hot spot in tumor research currently. In particular, immune checkpoint inhibitors have played an important role in the treatment of advanced unresectable primary liver cancer. However, the efficacy of immune checkpoint inhibitors varies greatly in the treatment of different patients, which has aroused people's attention to the regulatory mechanism of PD-L1 in the immune escape of liver tumors. PD-L1 is regulated by multiple levels and multiple signaling pathways in liver cancer, including gene mutation, epigenetic mechanisms, transcriptional regulation, post-transcriptional regulation and post-translational modification. Studies have also found that the high expression of PD-L1 may be the main factor affecting the immunotherapy of primary liver cancer. Therefore, it can provide more evidence for immunotherapy and immune combination therapy strategies of primary liver cancer by clarifying the regulatory mechanism of PD-L1.LI ShenghaoSHI XinliMagazine House of Cancer Research on Prevention and Treatmentarticleprimary liver cancerpd-l1immunotherapyregulatory mechanismNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ZHZhongliu Fangzhi Yanjiu, Vol 48, Iss 11, Pp 1052-1058 (2021)
institution	DOAJ
collection	DOAJ
language	ZH
topic	primary liver cancer pd-l1 immunotherapy regulatory mechanism Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	primary liver cancer pd-l1 immunotherapy regulatory mechanism Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 LI Shenghao SHI Xinli Regulatory Mechanism of PD-L1 Expression in Primary Liver Cancer
description	The application of immunotherapy has become a hot spot in tumor research currently. In particular, immune checkpoint inhibitors have played an important role in the treatment of advanced unresectable primary liver cancer. However, the efficacy of immune checkpoint inhibitors varies greatly in the treatment of different patients, which has aroused people's attention to the regulatory mechanism of PD-L1 in the immune escape of liver tumors. PD-L1 is regulated by multiple levels and multiple signaling pathways in liver cancer, including gene mutation, epigenetic mechanisms, transcriptional regulation, post-transcriptional regulation and post-translational modification. Studies have also found that the high expression of PD-L1 may be the main factor affecting the immunotherapy of primary liver cancer. Therefore, it can provide more evidence for immunotherapy and immune combination therapy strategies of primary liver cancer by clarifying the regulatory mechanism of PD-L1.
format	article
author	LI Shenghao SHI Xinli
author_facet	LI Shenghao SHI Xinli
author_sort	LI Shenghao
title	Regulatory Mechanism of PD-L1 Expression in Primary Liver Cancer
title_short	Regulatory Mechanism of PD-L1 Expression in Primary Liver Cancer
title_full	Regulatory Mechanism of PD-L1 Expression in Primary Liver Cancer
title_fullStr	Regulatory Mechanism of PD-L1 Expression in Primary Liver Cancer
title_full_unstemmed	Regulatory Mechanism of PD-L1 Expression in Primary Liver Cancer
title_sort	regulatory mechanism of pd-l1 expression in primary liver cancer
publisher	Magazine House of Cancer Research on Prevention and Treatment
publishDate	2021
url	https://doaj.org/article/aeb6ca2b49204a9f9fbb56777e5f963a
work_keys_str_mv	AT lishenghao regulatorymechanismofpdl1expressioninprimarylivercancer AT shixinli regulatorymechanismofpdl1expressioninprimarylivercancer
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Regulatory Mechanism of PD-L1 Expression in Primary Liver Cancer

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