Neurogenesis from Sox2 expressing cells in the adult cerebellar cortex

Abstract We identified a rare undifferentiated cell population that is intermingled with the Bergmann glia of the adult murine cerebellar cortex, expresses the stem cell markers Sox2 and Nestin, and lacks markers of glial or neuronal differentiation. Interestingly, such Sox2+ S100− cells of the adul...

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Autores principales:	Julia Ahlfeld, Severin Filser, Felix Schmidt, Annika K. Wefers, Daniel J. Merk, Rainer Glaß, Jochen Herms, Ulrich Schüller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aeba864d42ef41fea54c73bb5845c5de
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spelling	oai:doaj.org-article:aeba864d42ef41fea54c73bb5845c5de2021-12-02T12:32:24ZNeurogenesis from Sox2 expressing cells in the adult cerebellar cortex10.1038/s41598-017-06150-x2045-2322https://doaj.org/article/aeba864d42ef41fea54c73bb5845c5de2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06150-xhttps://doaj.org/toc/2045-2322Abstract We identified a rare undifferentiated cell population that is intermingled with the Bergmann glia of the adult murine cerebellar cortex, expresses the stem cell markers Sox2 and Nestin, and lacks markers of glial or neuronal differentiation. Interestingly, such Sox2+ S100− cells of the adult cerebellum expanded after adequate physiological stimuli in mice (exercise), and Sox2+ precursors acquired positivity for the neuronal marker NeuN over time and integrated into cellular networks. In human patients, SOX2+ S100− cells similarly increased in number after relevant pathological insults (infarcts), suggesting a similar expansion of cells that lack terminal glial differentiation.Julia AhlfeldSeverin FilserFelix SchmidtAnnika K. WefersDaniel J. MerkRainer GlaßJochen HermsUlrich SchüllerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julia Ahlfeld Severin Filser Felix Schmidt Annika K. Wefers Daniel J. Merk Rainer Glaß Jochen Herms Ulrich Schüller Neurogenesis from Sox2 expressing cells in the adult cerebellar cortex
description	Abstract We identified a rare undifferentiated cell population that is intermingled with the Bergmann glia of the adult murine cerebellar cortex, expresses the stem cell markers Sox2 and Nestin, and lacks markers of glial or neuronal differentiation. Interestingly, such Sox2+ S100− cells of the adult cerebellum expanded after adequate physiological stimuli in mice (exercise), and Sox2+ precursors acquired positivity for the neuronal marker NeuN over time and integrated into cellular networks. In human patients, SOX2+ S100− cells similarly increased in number after relevant pathological insults (infarcts), suggesting a similar expansion of cells that lack terminal glial differentiation.
format	article
author	Julia Ahlfeld Severin Filser Felix Schmidt Annika K. Wefers Daniel J. Merk Rainer Glaß Jochen Herms Ulrich Schüller
author_facet	Julia Ahlfeld Severin Filser Felix Schmidt Annika K. Wefers Daniel J. Merk Rainer Glaß Jochen Herms Ulrich Schüller
author_sort	Julia Ahlfeld
title	Neurogenesis from Sox2 expressing cells in the adult cerebellar cortex
title_short	Neurogenesis from Sox2 expressing cells in the adult cerebellar cortex
title_full	Neurogenesis from Sox2 expressing cells in the adult cerebellar cortex
title_fullStr	Neurogenesis from Sox2 expressing cells in the adult cerebellar cortex
title_full_unstemmed	Neurogenesis from Sox2 expressing cells in the adult cerebellar cortex
title_sort	neurogenesis from sox2 expressing cells in the adult cerebellar cortex
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/aeba864d42ef41fea54c73bb5845c5de
work_keys_str_mv	AT juliaahlfeld neurogenesisfromsox2expressingcellsintheadultcerebellarcortex AT severinfilser neurogenesisfromsox2expressingcellsintheadultcerebellarcortex AT felixschmidt neurogenesisfromsox2expressingcellsintheadultcerebellarcortex AT annikakwefers neurogenesisfromsox2expressingcellsintheadultcerebellarcortex AT danieljmerk neurogenesisfromsox2expressingcellsintheadultcerebellarcortex AT rainerglaß neurogenesisfromsox2expressingcellsintheadultcerebellarcortex AT jochenherms neurogenesisfromsox2expressingcellsintheadultcerebellarcortex AT ulrichschuller neurogenesisfromsox2expressingcellsintheadultcerebellarcortex
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Neurogenesis from Sox2 expressing cells in the adult cerebellar cortex

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