Cognitive status in patients with multiple sclerosis in Lanzarote

María Yaiza Pérez-Martín,1 Pablo Eguia-del Río,2 Montserrat González-Platas,1 Alejandro Jiménez-Sosa31Service of Neurology, Complejo Hospitalario Universitario de Canarias, La Laguna, 2Service of Neurology, Doctor José Moli...

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Autores principales:	Pérez-Martín MY, Eguia-del Rio P, González-Platas M, Jiménez-Sosa A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Cognitive status Cognitive impairment Lanzarote Multiple Sclerosis. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/aebe31cc53c141808067bba6498ed44c
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spelling	oai:doaj.org-article:aebe31cc53c141808067bba6498ed44c2021-12-02T02:11:29ZCognitive status in patients with multiple sclerosis in Lanzarote1178-2021https://doaj.org/article/aebe31cc53c141808067bba6498ed44c2016-06-01T00:00:00Zhttps://www.dovepress.com/cognitive-status-in-patients-with-multiple-sclerosis-in-lanzarote-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021María Yaiza Pérez-Martín,1 Pablo Eguia-del Río,2 Montserrat González-Platas,1 Alejandro Jiménez-Sosa31Service of Neurology, Complejo Hospitalario Universitario de Canarias, La Laguna, 2Service of Neurology, Doctor José Molina Orosa Hospital, Arrecife, Lanzarote, 3Unit of Research, Complejo Hospitalario Universitario de Canarias, La Laguna, SpainObjectives: Cognitive impairment is a common feature in multiple sclerosis affecting ~43%–72% of patients, which involves cognitive functions such as memory, processing speed, attention, and executive function. The aim of this study was to describe the extent and pattern of the involvement of cognitive impairment and psychological status in all patients with multiple sclerosis on a small Spanish island.Patients and methods: In all, 70 patients and 56 healthy controls were included in the study between February 2013 and May 2013. All participants were assessed using the Brief Repeatable Battery of Neuropsychological Test. The patients also completed instruments to evaluate the presence of fatigue, perceived cognitive dysfunction, and symptoms of anxiety and depression. All procedures were performed in a single session.Results: Cognitive impairment, defined as a score <1.5 standard deviation on two subtests of the battery, was present in 35% of the participants. The most frequently affected domain was working memory, followed by verbal memory and processing speed. Disease duration showed a moderate correlation with visuospatial memory and processing speed. The Expanded Disability Status Scale score correlated with verbal and processing speed. Verbal memory was correlated with depression symptoms and fatigue.Conclusion: Cognitive impairment was present in 35% of the study population. The most affected domains were working memory and verbal memory. Working memory and verbal fluency deficit are independent factors of disease evolution. Cognitive decline is related to clinical variables and psychological measures such as fatigue or depression but not to anxiety.Keywords: cognitive status, cognitive impairment, Lanzarote, multiple sclerosisPérez-Martín MYEguia-del Rio PGonzález-Platas MJiménez-Sosa ADove Medical PressarticleCognitive statusCognitive impairmentLanzaroteMultiple Sclerosis.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 1553-1559 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cognitive status Cognitive impairment Lanzarote Multiple Sclerosis. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Cognitive status Cognitive impairment Lanzarote Multiple Sclerosis. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Pérez-Martín MY Eguia-del Rio P González-Platas M Jiménez-Sosa A Cognitive status in patients with multiple sclerosis in Lanzarote
description	María Yaiza Pérez-Martín,1 Pablo Eguia-del Río,2 Montserrat González-Platas,1 Alejandro Jiménez-Sosa31Service of Neurology, Complejo Hospitalario Universitario de Canarias, La Laguna, 2Service of Neurology, Doctor José Molina Orosa Hospital, Arrecife, Lanzarote, 3Unit of Research, Complejo Hospitalario Universitario de Canarias, La Laguna, SpainObjectives: Cognitive impairment is a common feature in multiple sclerosis affecting ~43%–72% of patients, which involves cognitive functions such as memory, processing speed, attention, and executive function. The aim of this study was to describe the extent and pattern of the involvement of cognitive impairment and psychological status in all patients with multiple sclerosis on a small Spanish island.Patients and methods: In all, 70 patients and 56 healthy controls were included in the study between February 2013 and May 2013. All participants were assessed using the Brief Repeatable Battery of Neuropsychological Test. The patients also completed instruments to evaluate the presence of fatigue, perceived cognitive dysfunction, and symptoms of anxiety and depression. All procedures were performed in a single session.Results: Cognitive impairment, defined as a score <1.5 standard deviation on two subtests of the battery, was present in 35% of the participants. The most frequently affected domain was working memory, followed by verbal memory and processing speed. Disease duration showed a moderate correlation with visuospatial memory and processing speed. The Expanded Disability Status Scale score correlated with verbal and processing speed. Verbal memory was correlated with depression symptoms and fatigue.Conclusion: Cognitive impairment was present in 35% of the study population. The most affected domains were working memory and verbal memory. Working memory and verbal fluency deficit are independent factors of disease evolution. Cognitive decline is related to clinical variables and psychological measures such as fatigue or depression but not to anxiety.Keywords: cognitive status, cognitive impairment, Lanzarote, multiple sclerosis
format	article
author	Pérez-Martín MY Eguia-del Rio P González-Platas M Jiménez-Sosa A
author_facet	Pérez-Martín MY Eguia-del Rio P González-Platas M Jiménez-Sosa A
author_sort	Pérez-Martín MY
title	Cognitive status in patients with multiple sclerosis in Lanzarote
title_short	Cognitive status in patients with multiple sclerosis in Lanzarote
title_full	Cognitive status in patients with multiple sclerosis in Lanzarote
title_fullStr	Cognitive status in patients with multiple sclerosis in Lanzarote
title_full_unstemmed	Cognitive status in patients with multiple sclerosis in Lanzarote
title_sort	cognitive status in patients with multiple sclerosis in lanzarote
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/aebe31cc53c141808067bba6498ed44c
work_keys_str_mv	AT perezmartinmy cognitivestatusinpatientswithmultiplesclerosisinlanzarote AT eguiadelriop cognitivestatusinpatientswithmultiplesclerosisinlanzarote AT gonzalezplatasm cognitivestatusinpatientswithmultiplesclerosisinlanzarote AT jimenezsosaa cognitivestatusinpatientswithmultiplesclerosisinlanzarote
_version_	1718402614766338048

Cognitive status in patients with multiple sclerosis in Lanzarote

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