Development and research of a model for differential diagnosis of latent late syphilis and false-positive serological reactions on immunochips with a panel of 12 Treponema pallidum antigens

The aim - to find the optimal attributing rules to distinguish groups of latent stages of syphilis and false positive serological tests of using multivariate discriminant analysis Material and methods. The objects of the study were serum samples from patients with late latent (N=34) syphilis and...

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Autores principales:	Marina V. Shpilevaya, Georgiy L. Katunin, Alexey A. Kubanov
Formato:	article
Lenguaje:	RU
Publicado:	State Scientific Center of Dermatovenereology and Cosmetology 2021
Materias:	false positive results of serological test for syphilis late latent syphilis multivariate discriminant analysis Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/aec0a2da935f4e8a848a133304d69504
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spelling	oai:doaj.org-article:aec0a2da935f4e8a848a133304d695042021-12-01T22:16:30ZDevelopment and research of a model for differential diagnosis of latent late syphilis and false-positive serological reactions on immunochips with a panel of 12 Treponema pallidum antigens0042-46092313-629410.25208/vdv1229https://doaj.org/article/aec0a2da935f4e8a848a133304d695042021-07-01T00:00:00Zhttps://vestnikdv.ru/jour/article/viewFile/1229/1205https://doaj.org/toc/0042-4609https://doaj.org/toc/2313-6294The aim - to find the optimal attributing rules to distinguish groups of latent stages of syphilis and false positive serological tests of using multivariate discriminant analysis Material and methods. The objects of the study were serum samples from patients with late latent (N=34) syphilis and false positive serological tests (N=31). The samples were studied to determine IgG and IgM levels using indirect immunofluorescent reaction with immunochip containing recombinant antigens T. pallidum Results The mathematical model allows to differentiate with a high degree of confidence patients with late latent syphilis and with false-positive serological reactions to syphilis. Conclusions. . Multivariate discriminant analysis makes possible to create reliable mathematical models to classify patients with late latent syphilis and with false-positive serological reactions to syphilis.Marina V. ShpilevayaGeorgiy L. KatuninAlexey A. KubanovState Scientific Center of Dermatovenereology and Cosmetologyarticlefalse positive results of serological test for syphilislate latent syphilismultivariate discriminant analysisDermatologyRL1-803RUVestnik Dermatologii i Venerologii, Vol 97, Iss 3, Pp 39-46 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	false positive results of serological test for syphilis late latent syphilis multivariate discriminant analysis Dermatology RL1-803
spellingShingle	false positive results of serological test for syphilis late latent syphilis multivariate discriminant analysis Dermatology RL1-803 Marina V. Shpilevaya Georgiy L. Katunin Alexey A. Kubanov Development and research of a model for differential diagnosis of latent late syphilis and false-positive serological reactions on immunochips with a panel of 12 Treponema pallidum antigens
description	The aim - to find the optimal attributing rules to distinguish groups of latent stages of syphilis and false positive serological tests of using multivariate discriminant analysis Material and methods. The objects of the study were serum samples from patients with late latent (N=34) syphilis and false positive serological tests (N=31). The samples were studied to determine IgG and IgM levels using indirect immunofluorescent reaction with immunochip containing recombinant antigens T. pallidum Results The mathematical model allows to differentiate with a high degree of confidence patients with late latent syphilis and with false-positive serological reactions to syphilis. Conclusions. . Multivariate discriminant analysis makes possible to create reliable mathematical models to classify patients with late latent syphilis and with false-positive serological reactions to syphilis.
format	article
author	Marina V. Shpilevaya Georgiy L. Katunin Alexey A. Kubanov
author_facet	Marina V. Shpilevaya Georgiy L. Katunin Alexey A. Kubanov
author_sort	Marina V. Shpilevaya
title	Development and research of a model for differential diagnosis of latent late syphilis and false-positive serological reactions on immunochips with a panel of 12 Treponema pallidum antigens
title_short	Development and research of a model for differential diagnosis of latent late syphilis and false-positive serological reactions on immunochips with a panel of 12 Treponema pallidum antigens
title_full	Development and research of a model for differential diagnosis of latent late syphilis and false-positive serological reactions on immunochips with a panel of 12 Treponema pallidum antigens
title_fullStr	Development and research of a model for differential diagnosis of latent late syphilis and false-positive serological reactions on immunochips with a panel of 12 Treponema pallidum antigens
title_full_unstemmed	Development and research of a model for differential diagnosis of latent late syphilis and false-positive serological reactions on immunochips with a panel of 12 Treponema pallidum antigens
title_sort	development and research of a model for differential diagnosis of latent late syphilis and false-positive serological reactions on immunochips with a panel of 12 treponema pallidum antigens
publisher	State Scientific Center of Dermatovenereology and Cosmetology
publishDate	2021
url	https://doaj.org/article/aec0a2da935f4e8a848a133304d69504
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Development and research of a model for differential diagnosis of latent late syphilis and false-positive serological reactions on immunochips with a panel of 12 Treponema pallidum antigens

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