Mitochondria-Targeted Self-Assembly of Peptide-Based Nanomaterials

Mitochondria are well known to serve as the powerhouse for cells and also the initiator for some vital signaling pathways. A variety of diseases are discovered to be associated with the abnormalities of mitochondria, including cancers. Thus, targeting mitochondria and their metabolisms are recognize...

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Autores principales:	Zhen Luo, Yujuan Gao, Zhongyu Duan, Yu Yi, Hao Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	mitochondrion self-assembly peptide enzyme nanomaterials cancer therapy Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/aec169843f004e8896addaa3fd905b4b
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spelling	oai:doaj.org-article:aec169843f004e8896addaa3fd905b4b2021-12-01T08:12:49ZMitochondria-Targeted Self-Assembly of Peptide-Based Nanomaterials2296-418510.3389/fbioe.2021.782234https://doaj.org/article/aec169843f004e8896addaa3fd905b4b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.782234/fullhttps://doaj.org/toc/2296-4185Mitochondria are well known to serve as the powerhouse for cells and also the initiator for some vital signaling pathways. A variety of diseases are discovered to be associated with the abnormalities of mitochondria, including cancers. Thus, targeting mitochondria and their metabolisms are recognized to be promising for cancer therapy. In recent years, great efforts have been devoted to developing mitochondria-targeted pharmaceuticals, including small molecular drugs, peptides, proteins, and genes, with several molecular drugs and peptides enrolled in clinical trials. Along with the advances of nanotechnology, self-assembled peptide-nanomaterials that integrate the biomarker-targeting, stimuli-response, self-assembly, and therapeutic effect, have been attracted increasing interest in the fields of biotechnology and nanomedicine. Particularly, in situ mitochondria-targeted self-assembling peptides that can assemble on the surface or inside mitochondria have opened another dimension for the mitochondria-targeted cancer therapy. Here, we highlight the recent progress of mitochondria-targeted peptide-nanomaterials, especially those in situ self-assembly systems in mitochondria, and their applications in cancer treatments.Zhen LuoZhen LuoYujuan GaoZhongyu DuanYu YiYu YiHao WangHao WangFrontiers Media S.A.articlemitochondrionself-assemblypeptideenzymenanomaterialscancer therapyBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mitochondrion self-assembly peptide enzyme nanomaterials cancer therapy Biotechnology TP248.13-248.65
spellingShingle	mitochondrion self-assembly peptide enzyme nanomaterials cancer therapy Biotechnology TP248.13-248.65 Zhen Luo Zhen Luo Yujuan Gao Zhongyu Duan Yu Yi Yu Yi Hao Wang Hao Wang Mitochondria-Targeted Self-Assembly of Peptide-Based Nanomaterials
description	Mitochondria are well known to serve as the powerhouse for cells and also the initiator for some vital signaling pathways. A variety of diseases are discovered to be associated with the abnormalities of mitochondria, including cancers. Thus, targeting mitochondria and their metabolisms are recognized to be promising for cancer therapy. In recent years, great efforts have been devoted to developing mitochondria-targeted pharmaceuticals, including small molecular drugs, peptides, proteins, and genes, with several molecular drugs and peptides enrolled in clinical trials. Along with the advances of nanotechnology, self-assembled peptide-nanomaterials that integrate the biomarker-targeting, stimuli-response, self-assembly, and therapeutic effect, have been attracted increasing interest in the fields of biotechnology and nanomedicine. Particularly, in situ mitochondria-targeted self-assembling peptides that can assemble on the surface or inside mitochondria have opened another dimension for the mitochondria-targeted cancer therapy. Here, we highlight the recent progress of mitochondria-targeted peptide-nanomaterials, especially those in situ self-assembly systems in mitochondria, and their applications in cancer treatments.
format	article
author	Zhen Luo Zhen Luo Yujuan Gao Zhongyu Duan Yu Yi Yu Yi Hao Wang Hao Wang
author_facet	Zhen Luo Zhen Luo Yujuan Gao Zhongyu Duan Yu Yi Yu Yi Hao Wang Hao Wang
author_sort	Zhen Luo
title	Mitochondria-Targeted Self-Assembly of Peptide-Based Nanomaterials
title_short	Mitochondria-Targeted Self-Assembly of Peptide-Based Nanomaterials
title_full	Mitochondria-Targeted Self-Assembly of Peptide-Based Nanomaterials
title_fullStr	Mitochondria-Targeted Self-Assembly of Peptide-Based Nanomaterials
title_full_unstemmed	Mitochondria-Targeted Self-Assembly of Peptide-Based Nanomaterials
title_sort	mitochondria-targeted self-assembly of peptide-based nanomaterials
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/aec169843f004e8896addaa3fd905b4b
work_keys_str_mv	AT zhenluo mitochondriatargetedselfassemblyofpeptidebasednanomaterials AT zhenluo mitochondriatargetedselfassemblyofpeptidebasednanomaterials AT yujuangao mitochondriatargetedselfassemblyofpeptidebasednanomaterials AT zhongyuduan mitochondriatargetedselfassemblyofpeptidebasednanomaterials AT yuyi mitochondriatargetedselfassemblyofpeptidebasednanomaterials AT yuyi mitochondriatargetedselfassemblyofpeptidebasednanomaterials AT haowang mitochondriatargetedselfassemblyofpeptidebasednanomaterials AT haowang mitochondriatargetedselfassemblyofpeptidebasednanomaterials
_version_	1718405434258227200

Mitochondria-Targeted Self-Assembly of Peptide-Based Nanomaterials

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