Potential therapeutic effect of thymoquinone and/or bee pollen on fluvastatin-induced hepatitis in rats

Abstract Hepatitis is one of earlier, but serious, signs of liver damage. High doses of statins for a long time can induce hepatitis. This study aimed to evaluate and compare the therapeutic potential of thymoquinone (TQ) and bee pollen (BP) on fluvastatin (F)-induced hepatitis in rats. Rats were ra...

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Autores principales:	Amro E. Mohamed, Mohammed A. El-Magd, Karim S. El-Said, Mohamed El-Sharnouby, Ehab M. Tousson, Afrah F. Salama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aec8155fe6a94159a213afa36c6caaf4
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spelling	oai:doaj.org-article:aec8155fe6a94159a213afa36c6caaf42021-12-02T17:06:09ZPotential therapeutic effect of thymoquinone and/or bee pollen on fluvastatin-induced hepatitis in rats10.1038/s41598-021-95342-72045-2322https://doaj.org/article/aec8155fe6a94159a213afa36c6caaf42021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95342-7https://doaj.org/toc/2045-2322Abstract Hepatitis is one of earlier, but serious, signs of liver damage. High doses of statins for a long time can induce hepatitis. This study aimed to evaluate and compare the therapeutic potential of thymoquinone (TQ) and bee pollen (BP) on fluvastatin (F)-induced hepatitis in rats. Rats were randomly divided into: group 1 (G1, control), G2 (F, hepatitis), G3 (F + TQ), G4 (F + BP), and G5 (F + TQ + BP). Single treatment with TQ or BP relieved fluvastatin-induced hepatitis, with best effect for the combined therapy. TQ and/or BP treatment significantly (1) reduced serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transpeptidase, and total bilirubin, (2) decreased malondialdehyde levels and increased level of reduced glutathione, and activities of glutathione peroxidase and catalase in the liver, (3) improved liver histology with mild deposition of type I collagen, (4) increased mRNA levels of transforming growth factor beta 1, nuclear factor Kappa B, and cyclooxygenase 1 and 2, and (5) decreased tumor necrosis factor alpha and upregulated interleukin 10 protein in the liver. These data clearly highlight the ability of TQ and BP combined therapy to cause better ameliorative effects on fluvastatin-induced hepatitis than individual treatment by each alone.Amro E. MohamedMohammed A. El-MagdKarim S. El-SaidMohamed El-SharnoubyEhab M. ToussonAfrah F. SalamaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amro E. Mohamed Mohammed A. El-Magd Karim S. El-Said Mohamed El-Sharnouby Ehab M. Tousson Afrah F. Salama Potential therapeutic effect of thymoquinone and/or bee pollen on fluvastatin-induced hepatitis in rats
description	Abstract Hepatitis is one of earlier, but serious, signs of liver damage. High doses of statins for a long time can induce hepatitis. This study aimed to evaluate and compare the therapeutic potential of thymoquinone (TQ) and bee pollen (BP) on fluvastatin (F)-induced hepatitis in rats. Rats were randomly divided into: group 1 (G1, control), G2 (F, hepatitis), G3 (F + TQ), G4 (F + BP), and G5 (F + TQ + BP). Single treatment with TQ or BP relieved fluvastatin-induced hepatitis, with best effect for the combined therapy. TQ and/or BP treatment significantly (1) reduced serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transpeptidase, and total bilirubin, (2) decreased malondialdehyde levels and increased level of reduced glutathione, and activities of glutathione peroxidase and catalase in the liver, (3) improved liver histology with mild deposition of type I collagen, (4) increased mRNA levels of transforming growth factor beta 1, nuclear factor Kappa B, and cyclooxygenase 1 and 2, and (5) decreased tumor necrosis factor alpha and upregulated interleukin 10 protein in the liver. These data clearly highlight the ability of TQ and BP combined therapy to cause better ameliorative effects on fluvastatin-induced hepatitis than individual treatment by each alone.
format	article
author	Amro E. Mohamed Mohammed A. El-Magd Karim S. El-Said Mohamed El-Sharnouby Ehab M. Tousson Afrah F. Salama
author_facet	Amro E. Mohamed Mohammed A. El-Magd Karim S. El-Said Mohamed El-Sharnouby Ehab M. Tousson Afrah F. Salama
author_sort	Amro E. Mohamed
title	Potential therapeutic effect of thymoquinone and/or bee pollen on fluvastatin-induced hepatitis in rats
title_short	Potential therapeutic effect of thymoquinone and/or bee pollen on fluvastatin-induced hepatitis in rats
title_full	Potential therapeutic effect of thymoquinone and/or bee pollen on fluvastatin-induced hepatitis in rats
title_fullStr	Potential therapeutic effect of thymoquinone and/or bee pollen on fluvastatin-induced hepatitis in rats
title_full_unstemmed	Potential therapeutic effect of thymoquinone and/or bee pollen on fluvastatin-induced hepatitis in rats
title_sort	potential therapeutic effect of thymoquinone and/or bee pollen on fluvastatin-induced hepatitis in rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/aec8155fe6a94159a213afa36c6caaf4
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Potential therapeutic effect of thymoquinone and/or bee pollen on fluvastatin-induced hepatitis in rats

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